In order to analyze the influence of perfluororganic compounds (perfluorodecalin) on growth of Staphylococcus epidermidis there was an in vitro experiment conducted. During 24 hours St. epidermidis cell crop was grown on meat-peptone agar in the Petri dishes: 1.1 water-salt BSS+ solution, 1.2-3,5 ml BSS+ solution and 1 mg of vancomycin in 0,1 ml of 0.9% sodium chloride solution, 1.3 perfluororganic compound, 1.4 the mixture of perfluororganic compound and 1 mg of vancomycin in 0,1 ml of 0.9% sodium chloride solution. Similarly the Petri dishes were numbered and the second experiment was conducted when the initial Staphilococcus epidermidis concentration was two times reduced. To hold control the pure crop of bacteria was cultivated without adding any additional materials in cups 1.0 and 1.2. No growth of colonies were detected in cups 1,2,2,2, local absence of growth was found in 1.4,2,4. In cups 1.1 and 2.1 there was more intensive growth detected and approximately the same intensive growth of crop was found in cups 1.3, 2.3. comparing to the controlled crop. The findings confirm the effectiveness of vancomycin regarding Staphylococcus epidermidis and the possibility of its use together with perfluororganic compounds. This fact can be used in the process of treatment of postoperative endophthalmitis.