<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2022-7.1.15</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3301</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПСИХОЛОГИЯ И ПСИХИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PSYCHOLOGY AND PSYCHIATRY</subject></subj-group></article-categories><title-group><article-title>Кластеризация показателей когнитивного статуса кардиохирургических пациентов для оценки риска его послеоперационных изменений</article-title><trans-title-group xml:lang="en"><trans-title>Clustering of indicators of the cognitive status in cardiac surgery patients to assess the risk of postoperative decline</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7831-9404</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Разумникова</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Razumnikova</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор биологических наук, профессор кафедры психологии и педагогики, </p><p>630073, г. Новосибирск, пр. К. Маркса, 20</p></bio><bio xml:lang="en"><p> Dr.  Sc.  (Biol.), Professor at the Department of Psychology and Pedagogics, </p><p>Karla Marksa prospect 20, Novosibirsk 630073</p></bio><email xlink:type="simple">razoum@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6391-0170</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, ведущий научный сотрудник лаборатории нейрососудистой патологии, </p><p>650002, г. Кемерово, Сосновый б-р, 6</p></bio><bio xml:lang="en"><p>Dr. Sc. (Med.), Leading Research Officer at the Laboratory of Neurovascular Pathology,</p><p>Sosnoviy blvd 6, Kemerovo 650002</p></bio><email xlink:type="simple">iriz78@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8260-8033</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубникова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Trubnikova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, заведующая лабораторией нейрососудистой патологии, </p><p>650002, г. Кемерово, Сосновый б-р, 6</p></bio><bio xml:lang="en"><p> Dr. Sc. (Med.), Head of the Laboratory of Neurovascular Pathology,</p><p>Sosnoviy blvd 6, Kemerovo 650002</p></bio><email xlink:type="simple">olgalet17@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4642-3610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>член-корреспондент РАН, директор, </p><p>650002, г. Кемерово, Сосновый б-р, 6</p></bio><bio xml:lang="en"><p>Corresponding Member of the RAS, Director,</p><p>Sosnoviy blvd 6, Kemerovo 650002</p></bio><email xlink:type="simple">olb61@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный технический университет»</institution></aff><aff xml:lang="en"><institution>Novosibirsk State Technical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»</institution></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>18</day><month>03</month><year>2022</year></pub-date><volume>7</volume><issue>1</issue><fpage>129</fpage><lpage>138</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Разумникова О.М., Тарасова И.В., Трубникова О.А., Барбараш О.Л., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Разумникова О.М., Тарасова И.В., Трубникова О.А., Барбараш О.Л.</copyright-holder><copyright-holder xml:lang="en">Razumnikova O.M., Tarasova I.V., Trubnikova O.A., Barbarash O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3301">https://www.actabiomedica.ru/jour/article/view/3301</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: определить информационную ценность психометрических показателей, используемых для комплексной оценки когнитивного статуса у пациентов, перенёсших кардиохирургические вмешательства, и поиск тех из них, которые помогли бы дифференцировать индивидуальную склонность к послеоперационной когнитивной дисфункции (ПОКД).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Методами кластеризации проанализированы данные расширенного психометрического тестирования 256 кардиохирургических пациентов, проведённого за 3–5 дней до и на 7–10-е сутки после операции с применением программного психофизиологического комплекса «Status PF».</p></sec><sec><title>Результаты</title><p>Результаты. Кластерный анализ позволил установить, что для скрининговой оценки риска ПОКД наиболее информативным является тестирование скорости реакции на зрительно предъявленные стимулы с обратной связью изменения экспозиции этих стимулов согласно индивидуальной скорости ответов и тестирование запоминания слов. Выделена «нестабильная» согласно кластерному составу группа, которая при анализе послеоперационных психометрических показателей характеризовались ухудшением вербальной памяти и ослаблением отмеченного в общей «стабильной» группе ускорения времени реакции на зрительные стимулы.</p></sec><sec><title>Заключение</title><p>Заключение. Использованные методы кластеризации позволили выделить на этапе подготовки к кардиохирургическому вмешательству тех пациентов с ИБС, которые обладают меньшими когнитивными резервами для восстановления после операции. Изменения взаимосвязи показателей сложной зрительно-моторной реакции, внимания и памяти в зависимости от принадлежности к выделенным кластерам дают основание предположить, что предоперационный период характеризуется дедифференциацией когнитивных функций, указывающей на состояние когнитивного дефицита. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>The aim of the study</title><p>The aim of the study. To determine the informational value of psychometric indicators used for the integral assessment of cognitive status in cardiac patients, and to find those that would help differentiate the individual sensibility to postoperative cognitive dysfunction (POCD).</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The clustering methods were analyzed the extended psychometric testing data in 256 cardiac surgery patients. The psychometric testing carried out 3–5 days before and on days 7–10 after surgery using the psychophysiological complex program “Status PF”.</p></sec><sec><title>Results</title><p>Results. The cluster analysis revealed that the most informative tests for a screening risk assessment of POCD are the testing the speed of response to visual stimuli with feedback of changes in the stimuli exposition according to the individual reaction time and the testing short-term memory (memorized words). While the analysis of postoperative psychometric indicators, the patients in a modified clustering group were characterized by a deterioration of verbal memory and a decrease of the time reaction to visual stimuli whereas that its observed acceleration in the general “stable” group.</p></sec><sec><title>Conclusion</title><p>Conclusion. The clustering methods enabled the identification of cardiac surgery patients in the preoperative stage who had less cognitive reserve for recovery after surgery. The changes in the relationship of complex visual and motor response, attention, and memory indicators, which depended on the belonging to the identified clusters, suggest that the preoperative period is characterized by the dedifferentiation of cognitive functions indicating a cognitive deficit. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>когнитивные функции</kwd><kwd>кластеризация</kwd><kwd>послеоперационная когнитивная дисфункция</kwd><kwd>кардиохирургические вмешательства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cognitive functions</kwd><kwd>clustering</kwd><kwd>postoperative cognitive dysfunction</kwd><kwd>cardiac surgery</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке РФФИ, проект № 19-29-01017.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Deckers K, Schievink SHJ, Rodriquez MMF, van Oostenbrugge RJ, van Boxtel MPJ, Verhey FRJ, et al. Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis. PLoS One. 2017; 12(9): e0184244. doi: 10.1371/journal.pone.0184244</mixed-citation><mixed-citation xml:lang="en">Deckers  K, Schievink  SHJ, Rodriquez  MMF, van  Oostenbrugge RJ, van Boxtel MPJ, Verhey FRJ, et al. Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis. PLoS One. 2017; 12(9): e0184244. doi: 10.1371/journal.pone.0184244</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Li J, Wu Y, Zhang D, Nie J. Associations between heart failure and risk of dementia: A PRISMA-compliant meta-analysis. Medicine (Baltimore). 2020; 99(5): e18492. doi: 10.1097/MD.0000000000018492</mixed-citation><mixed-citation xml:lang="en">Li J, Wu Y, Zhang  D, Nie  J. Associations between heart failure and risk of dementia: A  PRISMA-compliant meta-analysis. Medicine (Baltimore). 2020; 99(5): e18492. doi:  10.1097/MD.0000000000018492</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Liang X, Huang Y, Han X. Associations between coronary heart disease and risk of cognitive impairment: A meta-analysis. Brain Behav. 2021; 11(5): e02108. doi: 10.1002/brb3.2108</mixed-citation><mixed-citation xml:lang="en">Liang X, Huang Y, Han X. Associations between coronary heart disease and risk of cognitive impairment: A meta-analysis. Brain Behav. 2021; 11(5): e02108. doi: 10.1002/brb3.2108</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Трубникова О.А., Каган Е.С., Куприянова Т.В., Малева О.В., Аргунова Ю.А., Кухарева И.Н. Нейропсихологический статус пациентов со стабильной ишемической болезнью сердца и факторы на него влияющие. Комплексные проблемы сердечнососудистых заболеваний. 2017; (1): 112-121. doi: 10.17802/2306-1278-2017-1-112-121</mixed-citation><mixed-citation xml:lang="en">Trubnikova OA, Kagan ES, Kupriyanova TV, Maleva OV, Argunova YuA, Kukhareva IN. Neuropsychological status of patients with stable coronary artery disease and factors affecting it. Complex Issues of Cardiovascular Diseases. 2017; (1): 112-121. (In Russ.). doi: 10.17802/2306-1278-2017-1-112-121</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mahon S, Parmar P, Barker-Collo S, Krishnamurthi R, Jones K, Theadom A, et al. Determinants, prevalence, and trajectory of long-term post-stroke cognitive impairment: Results from a 4-year follow-up of the ARCOS-IV study. Neuroepidemiology. 2017; 49(3-4): 129-134. doi: 10.1159/000484606</mixed-citation><mixed-citation xml:lang="en">Mahon S, Parmar P, Barker-Collo S, Krishnamurthi R, Jones K, Theadom A, et al. Determinants, prevalence, and trajectory of longterm post-stroke cognitive impairment: Results from a 4-year follow-up of the ARCOS-IV study. Neuroepidemiology. 2017; 49(3-4): 129-134. doi: 10.1159/000484606</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Samieri C, Perier MC, Gaye B, Proust-Lima C, Helmer C, Dartigues JF, et al. Association of cardiovascular health level in older age with cognitive decline and incident dementia. JAMA. 2018; 320(7): 657-664. doi: 10.1001/jama.2018.11499</mixed-citation><mixed-citation xml:lang="en">Samieri C, Perier MC, Gaye B, Proust-Lima C, Helmer C, Dartigues JF, et al. Association of cardiovascular health level in older age with cognitive decline and incident dementia. JAMA. 2018; 320(7): 657-664. doi: 10.1001/jama.2018.11499</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Сырова И.Д., Ложкин И.С., Трубникова О.А., Артамонова А.И., Портнов Ю.М., Семенов С.Е. и др. Цереброваскулярные осложнения у пациентов с ишемической болезнью сердца, перенёсших коронарное шунтирование (пятилетнее наблюдение). Креативная кардиология. 2020; 14(4): 313-323. doi: 10.24022/1997-3187-2020-14-4-313-323</mixed-citation><mixed-citation xml:lang="en">Syrova ID, Lozhkin IS, Trubnikova OA, Artamonova AI, Portnov YuM, Semenov SE, et al. Cerebrovascular complications of patients with coronary heart disease who underwent coronary bypass surgery (five-year follow-up). Creative Cardiology. 2020; 14(4): 313-323. (In Russ.). doi: 10.24022/1997-3187-2020-14-4-313-323</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Тарасова И.В., Трубникова О.А., Куприянова Т.В., Соснина А.С., Сырова И.Д., Ложкин И.С. и др. Влияние стойкой послеоперационной когнитивной дисфункции на показатели качества жизни у пациентов в отдалённом послеоперационном периоде коронарного шунтирования. Кардиология и сердечно-сосудистая хирургия. 2020; 13(6): 489-496. doi: 10.17116/kardio202013061489</mixed-citation><mixed-citation xml:lang="en">Tarasova IV, Trubnikova OA, Kupriyanova TV, Sosnina AS, Syrova  ID, Lozhkin  IS, et  al. Impact of persistent postoperative cognitive dysfunction on quality of life in long-term postoperative period after coronary artery bypass grafting. Kardiologiya i Serdechno-Sosudistaya Khirurgiya. 2020; 13(6): 489-496. (In Russ.). doi: 10.17116/kardio202013061489</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Xing YL, Chen MA, Sun Y, Neradilek MB, Wu XT, Zhang D, et al. Atherosclerosis, its risk factors, and cognitive impairment in older adults. J Geriatr Cardiol. 2020; 17(7): 434-440. doi: 10.11909/j.issn.1671-5411.2020.07.006</mixed-citation><mixed-citation xml:lang="en">Xing YL, Chen MA, Sun Y, Neradilek MB, Wu XT, Zhang D, et  al. Atherosclerosis, its risk factors, and cognitive impairment in  older adults. J Geriatr Cardiol. 2020; 17(7): 434-440. doi: 10.11909/j.issn.1671-5411.2020.07.006</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Saver JL, Cushman M. Striving for ideal cardiovascular and brain health: It is never too early or too late. JAMA. 2018; 320(7): 645-647. doi: 10.1001/jama.2018.11002</mixed-citation><mixed-citation xml:lang="en">Saver  JL, Cushman  M. Striving for ideal cardiovascular and brain health: It is never too early or too late. JAMA. 2018; 320(7): 645-647. doi: 10.1001/jama.2018.11002</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Guo Q, Lu X, Gao Y, Zhang J, Yan B, Su D, et al. Cluster analysis: A new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients. Sci Rep. 2017; 7: 43965. doi: 10.1038/srep43965</mixed-citation><mixed-citation xml:lang="en">Guo Q, Lu  X, Gao Y, Zhang  J, Yan  B, Su  D, et  al. Cluster analysis: A new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients. Sci Rep. 2017; 7: 43965. doi: 10.1038/srep43965</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mayer F, Di Pucchio A, Lacorte E, Bacigalupo I, Marzolini F, Ferrante G, et al. An estimate of attributable cases of Alzheimer disease and vascular dementia due to modifiable risk factors: The impact of primary prevention in Europe and in Italy. Dement Geriatr Cogn Dis Extra. 2018; 8(1): 60-71. doi: 10.1159/000487079</mixed-citation><mixed-citation xml:lang="en">Mayer F, Di Pucchio A, Lacorte E, Bacigalupo I, Marzolini F, Ferrante G, et al. An estimate of attributable cases of Alzheimer disease and vascular dementia due to modifiable risk factors: The impact of primary prevention in Europe and in Italy. Dement Geriatr Cogn Dis Extra. 2018; 8(1): 60-71. doi: 10.1159/000487079</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Covello AL, Horwitz LI, Singhal S, Blaum CS, Li Y, Dodson JA. Cardiovascular disease and cumulative incidence of cognitive impairment in the Health and Retirement Study. BMC Geriatr. 2021; 21(1): 274. doi: 10.1186/s12877-021-02191-0</mixed-citation><mixed-citation xml:lang="en">Covello  AL, Horwitz  LI, Singhal  S, Blaum  CS, Li Y, Dodson JA. Cardiovascular disease and cumulative incidence of cognitive impairment in the Health and Retirement Study. BMC Geriatr. 2021; 21(1): 274. doi: 10.1186/s12877-021-02191-0</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips V. Mild cognitive impairment (MCI): Diagnosis, prevalence and quality of life. NY: Nova; 2017.</mixed-citation><mixed-citation xml:lang="en">Phillips V. Mild cognitive impairment (MCI): Diagnosis, prevalence and quality of life. NY: Nova; 2017.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Разумникова О.М. Когнитивные ресурсы и стратегии адаптации при старении, локальных повреждениях мозга или сенсорной депривации. Новосибирск: Изд-во НГТУ; 2020.</mixed-citation><mixed-citation xml:lang="en">Razumnikova  OM. Cognitive resources and adaptation strategies for aging, local brain damage, or sensory deprivation. Novosibirsk: NGTU Publ.; 2020. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Biesmans KE, van Aken L, Frunt EMJ, Wingbermühle PAM, Egger JIM. Inhibition, shifting and updating in relation to psychometric intelligence across ability groups in the psychiatric population. J Intellect Disabil Res. 2019; 63(2):149-160. doi: 10.1111/jir.12559</mixed-citation><mixed-citation xml:lang="en">Biesmans KE, van Aken L, Frunt EMJ, Wingbermühle PAM, Egger JIM. Inhibition, shifting and updating in relation to psychometric intelligence across ability groups in the psychiatric population. J Intellect Disabil Res. 2019; 63(2):149-160. doi: 10.1111/jir.12559</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Martin AK, Barker MS, Gibson EC, Robinson GA. Response initiation and inhibition and the relationship with fluid intelligence across the adult lifespan. Arch Clin Neuropsychol. 2021; 36(2): 231- 242. doi: 10.1093/arclin/acz044</mixed-citation><mixed-citation xml:lang="en">Martin AK, Barker MS, Gibson EC, Robinson GA. Response initiation and inhibition and the relationship with fluid intelligence across the adult lifespan. Arch Clin Neuropsychol. 2021; 36(2): 231- 242. doi: 10.1093/arclin/acz044</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kulason K, Nouchi R, Hoshikawa Y, Noda M, Okada Y, Kawashima R. The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial. Trials. 2016; 17: 334. doi: 10.1186/s13063-016-1476-0</mixed-citation><mixed-citation xml:lang="en">Kulason K, Nouchi R, Hoshikawa Y, Noda M, Okada Y, Kawashima R. The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial. Trials. 2016; 17: 334. doi: 10.1186/s13063-016-1476-0</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tait JL, Duckham RL, Milte CM, Main LC, Daly RM. Influence of sequential vs. simultaneous dual-task exercise training on cognitive function in older adults. Front Aging Neurosci. 2017; 9: 368. doi: 10.3389/fnagi.2017.00368</mixed-citation><mixed-citation xml:lang="en">Tait JL, Duckham RL, Milte CM, Main LC, Daly RM. Influence of sequential vs. simultaneous dual-task exercise training on cognitive function in older adults. Front Aging Neurosci. 2017; 9: 368. doi: 10.3389/fnagi.2017.00368</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ajtahed SS, Rezapour T, Etemadi S, Moradi H, Habibi Asgarabad M, Ekhtiari H. Efficacy of neurocognitive rehabilitation after coronary artery bypass graft surgery in improving quality of life: An interventional trial. Front Psychol. 2019; 10: 1759. doi: 10.3389/fpsyg.2019.01759</mixed-citation><mixed-citation xml:lang="en">Ajtahed SS, Rezapour T, Etemadi S, Moradi H, Habibi Asgarabad M, Ekhtiari H. Efficacy of neurocognitive rehabilitation after coronary artery bypass graft surgery in improving quality of life: An interventional trial. Front Psychol. 2019; 10: 1759. doi: 10.3389/fpsyg.2019.01759</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
