actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.12737/23736actabiomedica-321Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEЗАВИСИМОСТЬ РЕЗУЛЬТАТА ЛАЗЕРНОГО ЛЕЧЕНИЯ ГИПЕРТРОФИЧЕСКИХ РУБЦОВ ОТ ИСХОДНОЙ РЕАКТИВНОСТИ ОРГАНИЗМАDEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITYКобецМ. В.KobetsM. V.kobetsmv@gmail.comВасильеваЛ. С.VasilyevaL. S.lsvirk@mail.ruМедицинский центр ЗАО «Эндокринологический центр»Russian FederationФГБОУ ВО «Иркутский государственный медицинский университет»Russian Federation201628112016166065Copyright © Кобец М.В., Васильева Л.С., 20162016Кобец М.В., Васильева Л.С.Kobets M.V., Vasilyeva L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/321

Цель - выявление взаимосвязи между реактивностью организма и результатом лечения гипертрофических рубцов. Установлено, что при положительном результате лечения у пациенток был ниже контрольного уровень СТГ (0,5 ± 0,1 мме/мл) и выше - уровни прогестерона (6,0 ± 0,4 нмоль/л) и ФСГ (6,7 ± 0,5 мме/мл); при отрицательном результате выше индекс атерогенности (2,6 ± 0,2) и уровень СТГ (2,1 ± 0,5), ниже - уровни кортизола (346,8 ± 39 нмоль/л), тестостерона (1,5± 0,2мме/мл), lL-10 (3,89 ± 1,6 нг/мл) и антител к lFN-y (0,206 ± 0,05 отн. ед.), lFN-a (0,385 ± 0,02) и Fc-фрагментам (0,317 ± 0,04)

The purpose of the study was to identify the relationship between the initial state of the organism and the result of the treatment of hypertrophic scars. 38 women of 16-35years of age were examined on the 5-7th days of the menstrual cycle, 16 of them had normotrophic scars and 22 - hypertrophic scars. The quality of scars, lipid profile, the concentration of thyrotropin, free fraction of thyroxine, growth hormone (GH), luteinizing and follicle stimulating hormone (FSH), cortisol, prolactin, estradiol, testosterone, progesterone, the concentration of TNF-a, lL-4, lL-6, lL-10, and the level of autoantibodies to DNA, lFN-a, lFN-y, b2-glycoprotein, Fc-fragments, collagen-2 were determined. Further on the laser treatment was performed: the scar surface was treated by multiple perforations under local anesthesia. Treatment outcome was assessed in 3 months by the clinical characteristics of the scar. lt was found that in 10 women hypertrophic scars reformed in normotrophic scars after the treatment, and 12 women still had hypertrophic scars. Patients with a positive result of treatment had a low concentration of GH (0.5 ± 0.1) and high concentrations of progesterone (6.0 ± 0.4) and FSH (6.7 ± 0.5 in the follicular phase of the cycle). The negative result of the treatment obtained in patients with significant shifts reactivity indicators: high atherogenic index (2.6 ± 0.2) and the level of GH (2.1 ± 0.5), low levels of cortisol (346.8 ± 39), testosterone (1.5 ± 0.2), lL-10 (3.89 ± 1.6) and antibodies to lFN-y (0.206 ± 0.05), lFN-a (0.385 ± 0.02), Fc-fragments (0.317± 0.04).

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The authors declare that there are no conflicts of interest present.