We analysed the effect of prostoglandins analogues application on the course of postoperative period of cataract phakoemulsification in 58 patients with primary open-angle glaucoma. All patients before the operation had normal intraocular pressure (on average 15.6 ± 0.07 mm Hg), the optical coherent tomography showed normal parameters of retina thickness in 1 mm zone and the macula volume in 6 mm zone. Instillation of nonsteroid anti-inflammatory drug after the operation lasted 6-8 weeks, and prostoglandins analogues continued to be instillated during all period of observation. The course of the early postoperative period was areactive. Average visual acuity on the first day was 0.69 ± 0.05, in 6-8 weeks - 0.85 ± 0.05. The average level of intaocular pressure during application of prostoglandins analogues on first day was 16.9 ± 0.37 mm Hg, and in 6-8 weeks -15.1 ± 0.28 mm Hg. Optical coherence tomography revealed little change of retina thickness and macular area volume before the operation and in 6-8 weeks after it was regarded as an error of measurement method. Thus, continuation of instillations of prostoglandins analogues in pre- and postoperative period in uncomplicated phakoemulsification in patients with primary open-angle glaucoma promote continuity in treatment, support com-plience and provide stable intraocular pressure without the expressed reactive hypertensia. Application of nonsteroid anti-inflammatory drug during 6-8 weeks after phakoemulsification in patients with primary open-angle glaucoma serves as an effective measure of prevention of inflammation of an anterior and posterior eye segment during prostoglandins analogues treatrment.