actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2021-6.6-2.5actabiomedica-3136Research ArticleМИКРОБИОЛОГИЯ И ВИРУСОЛОГИЯMICROBIOLOGY AND VIRUSOLOGYПерспективы создания антимикробных препаратов на основе наночастиц меди и оксидов медиProspects for the creation of antimicrobial preparations based on copper and copper oxides nanoparticleshttps://orcid.org/0000-0002-1551-5440НевежинаА. В.NevezhinaA. V.

 младший научный сотрудник лаборатории клеточных технологий и регенеративной медицины

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

 Junior Research Officer at the Laboratory of Cell Technologies and Regenerative Medicine

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

n4nnna@yandex.ruhttps://orcid.org/0000-0002-4681-905XФадееваТ. В.FadeevaT. V.

 доктор биологических наук, ведущий научный сотрудник лаборатории клеточных технологий и регенеративной медицины 

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

 Dr. Sc. (Biol.), Leading Research Officer at the Laboratory of Cell Technologies and Regenerative Medicine 

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

fadeeva05@yandex.ruФГБНУ «Иркутский научный центр хирургии и травматологии»Irkutsk Scientific Center of Surgery and Traumatology20212812202166-23750Copyright © Невежина А.В., Фадеева Т.В., 20212021Невежина А.В., Фадеева Т.В.Nevezhina A.V., Fadeeva T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/3136

Распространение полирезистентных к современным антимикробным препаратам штаммов микроорганизмов по-прежнему остаётся актуальной проблемой лечения и профилактики инфекционных заболеваний и общественного здравоохранения в целом.В настоящее время активно изучается возможность применения нанопрепаратов металлов в различных областях медицины. Наночастицы металлов и оксидов металлов являются перспективными антимикробными агентами и вызывают растущий интерес благодаря своей эффективности. Металлические частицы меди в наномасштабе продемонстрировали высокую антимикробную активность против различных видов грамположительных и грамотрицательных бактерий, а также грибков. Учитывая потенциал наночастиц меди и её оксидов в противомикробной терапии, мы представляем обзор современного состояния исследований, связанных с их антимикробными свойствами, рассмотрением механизмов действия, ключевых факторов, влияющих на антимикробную активность, в том числе полимерной матрицы. Рассмотрены вопросы токсичности и устойчивости к меди. Показано преимущество наночастиц меди и оксидов меди перед другими металлическими наночастицами.Обобщённые в этом обзоре исследования показали перспективность наночастиц меди в создании новых антимикробных препаратов, которые в будущем могут быть использованы для контроля, профилактики и лечения различных заболеваний.

The spread of strains of microorganisms that are multidrug resistant to modern antimicrobial drugs is still an urgent problem in the treatment and prevention of infectious diseases and public health in general.Currently, the possibility of using metal nanopreparations in various fields of medicine is being actively studied. Nanoparticles of metals and metal oxides are promising antimicrobial agents and are attracting growing interest due to their effectiveness. Nanoscale copper metal particles have shown high antimicrobial activity againstvarious types of gram-positive and gram-negative bacteria, as well as fungi. Taking into account the potential of copper nanoparticles in antimicrobial therapy, we present an overview of the current state of research related to their antimicrobial properties, consideration of the mechanisms of action, key factors affecting antimicrobial activity, including the polymer matrix. The issues of toxicity and resistance to copper are considered. The advantage of copper nanoparticles over other metal nanoparticles is shown.The studies summarized in this review have shown the promise of copper nanoparticles in the creation of new antimicrobial drugs that can be used in the future to control, prevent, and treat various diseases.

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The authors declare that there are no conflicts of interest present.