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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2021-6.6-1.27</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3131</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPHTHALMOLOGY</subject></subj-group></article-categories><title-group><article-title>Хориоидальные каверны при пахихориоидальной неоваскулопатии</article-title><trans-title-group xml:lang="en"><trans-title>Choroidal caverns in pachychoroid neovasculopathy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5191-3385</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Педанова</surname><given-names>Е. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Pedanova</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p> кандидат медицинских наук, научный сотрудник отдела лазерной хирургии сетчатки</p><p>127486, г. Москва, Бескудниковский бульвар, 59А, Россия </p></bio><bio xml:lang="en"><p> Cand. Sc. (Med.), Research Offi cer at the Retina Laser Surgery Department</p><p> Beskudnikovsky blvd 59a, Moscow 127486, Russian Federation </p></bio><email xlink:type="simple">elenamntk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» имени академика С.Н. Фёдорова» Минздрава России</institution></aff><aff xml:lang="en"><institution>S. Fyodorov Eye Microsurgery Federal State Institution </institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2021</year></pub-date><volume>6</volume><issue>6-1</issue><fpage>237</fpage><lpage>243</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Педанова Е.К., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Педанова Е.К.</copyright-holder><copyright-holder xml:lang="en">Pedanova E.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3131">https://www.actabiomedica.ru/jour/article/view/3131</self-uri><abstract><p>Обоснование. В настоящее время в патогенезе заболеваний сетчатки большая роль отводится состоянию сосудистой оболочки. Недавно выявленная находка оптической когерентной томографии (ОКТ) – хориоидальная каверна – описана при некоторых формах ретинальной патологии. В литературе имеются лишь единичные работы изучения хориоидальных каверн при пахихориоидальной неоваскулопатии.Цель исследования. Провести детальный анализ данных строения сосудистой оболочки на ОКТ-сканах пациентов с пахихориоидальной неоваскулопатией и выявить частоту идентификации хориоидальных каверн.Материал и методы. Ретроспективно проанализированы данные 30 пациентов (30 глаз) в возрасте 64,4 ± 5,6 года с пахихориоидальной неоваскуляризацией. Пациентам проводилась спектральная ОКТ и ОКТ-ангиография (ОКТА) на приборе Spectralis (Heidelberg Engineering, Германия). Применялся протокол «Posterior Pole», состоящий из 61 скана. Для оценки строения хориоидеи использовался модуль улучшенной глубины изображения (EDI, enhanced depth imaging). ОКТ-ангиография проводилась с площадью сканирования 6 × 6 мм. Данные методов сопоставлялись для выявления хориоидальных каверн.Результаты. На ОКТ и ОКТА субретинальная неоваскуляризация выявлена в виде плоской отслойки пигментного эпителия и визуализацией кровотока в виде петель (21 глаз) или веера (9 глаз). На сканах ОКТ-EDI в сосудистой оболочке имелось её диффузное или локальное утолщение с увеличением сосудов слоя Галлера и истончением хориокапилляров. Хориоидальные каверны выглядели на ОКТ и анфас-ОКТ как области с низкой оптической плотностью круглой или неправильной формы, расположенные в разных слоях хориоидеи, не имеющие гиперрефлективных границ. Типичный признак – хвост гипертрансмиссии после каверны. Хориоидальные каверны обнаружены на 4 из 30 глаз (13,3 %) и располагались как вблизи неоваскуляризации, так и за её пределами.Заключение. Распространённость хориоидальных каверн, нового хориоидального биомаркера, при пахихориоидальной неоваскулопатии составила 13,3 %. Выявление данных изменений возможно при использовании современных диагностических методик, позволяющих визуализировать состояние сосудистой оболочки. Прогностическая значимость хориоидальных каверн требует дальнейшего изучения.</p></abstract><trans-abstract xml:lang="en"><p>Background. Choroid plays an important role in the pathogenesis of retinal pathology. Choroidal cavern, a recently identifi ed fi nding of optical coherent tomography (OCT), has been described in some degenerative and atrophic forms of retinal pathology. In the literature, there are only a few studies of choroidal cavers in pachychoroid neovasculopathy, newly described form of age related macular degeneration.The aim: to perform a detailed analysis of choroidal structure on OCT scans of patients with pachychoroid neovasculopathy and to reveal the frequency of choroidal caverns identifi cation.Material and methods. The data of 30 patients (30 eyes) aged 64.4 ± 5.6 years with pachychoroid neovascularization were retrospectively analyzed. The patients underwent spectral OCT and OCT-angiography (OCTA) using a Spectralis device (Heidelberg Engineering, Germany). The protocol was “Posterior Pole”, consisting of 61 scans. To assess the structure of the choroid, an enhanced image depth (EDI) module was used. OCT angiography was performed with a scan area of 6 × 6 mm. These methods were compared to identify choroidal caverns.Results. On OCT subretinal type 1 neovascularization was revealed as a fl at detachment of the pigment epithelium and visualization of blood flow on OCTA in the lesion as angled vessels (21 eyes) or a seafan (9 eyes). On OCT-EDI scans, there was diffuse or local choroidal thickening of choroid with an increase in the vessels of the Haller’s layer and thinning of the choriocapillaries. Choroidal caverns appeared on OCT and en-face OCT as areas with low optical density, round or irregular, located in different layers of the chorioid, without hyperrefl ective boundaries. A typical sign of choroidal cavern is the tail of hypertransmission after the cavern toward the sclera. Choroidal caverns were found in 4 of 30 eyes (13.3 %) and were located both near the choroidal neovascularization lesion and beyond this area.Conclusion. The prevalence of choroidal cavities, a new choroidal biomarker, in pachychoroid neovasculopathy was 13.3 %. Identification of these changes is possible with the use of modern diagnostic techniques (OCT-EDI, OCTA and en-face OCT) that allow visualization the state of the choroid. The prognostic signifi cance of choroidal cavities requires further study.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хориоидальные каверны</kwd><kwd>пахихориоидальная неоваскулопатия</kwd><kwd>ОКТ-ангиография</kwd><kwd>хориоидальный биомаркер</kwd></kwd-group><kwd-group xml:lang="en"><kwd>choroidal caverns</kwd><kwd>pachychoroid neovasculopathy</kwd><kwd>OCT angiography</kwd><kwd>choroidal biomarker</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bird AC, Phillips RL, Hageman GS. Geographic atrophy: a histopathological assessment. JAMA Ophthalmol. 2014; 132(3): 338-345. doi: 10.1001/jamaophthalmol.2013.5799</mixed-citation><mixed-citation xml:lang="en">Bird AC, Phillips RL, Hageman GS. 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