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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2021-6.6-1.26</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3130</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPHTHALMOLOGY</subject></subj-group></article-categories><title-group><article-title>Ультрафиолетовый кросслинкинг роговичного коллагена у пациентов с тонкой роговицей. Обзор литературы</article-title><trans-title-group xml:lang="en"><trans-title>Ultraviolet crosslinking of corneal collagen in patients with thin cornea. Literature review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0840-2675</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, директор</p><p>248007, г. Калуга, ул. Святослава Фёдорова, 5, Россия</p></bio><bio xml:lang="en"><p> Dr. Sc. (Med.), Director</p><p> Svyatoslava Fedorova str. 5, Kaluga 248007, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9202-5181</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трифаненкова</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Trifanenkova</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p> кандидат медицинских наук, заместитель директора по научной работе </p><p>248007, г. Калуга, ул. Святослава Фёдорова, 5, Россия</p></bio><bio xml:lang="en"><p> Dr. Sc. (Med.), Deputy Director for Research </p><p> Svyatoslava Fedorova str. 5, Kaluga 248007, Russian Federation </p></bio><email xlink:type="simple">nauka@eye-kaluga.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1739-8871</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голубева</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Golubeva</surname><given-names>Yu. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p> врач-офтальмолог отделения оптико-реконструктивной и рефракционной хирургии роговицы</p><p>248007, г. Калуга, ул. Святослава Фёдорова, 5, Россия</p></bio><bio xml:lang="en"><p> Ophthalmologist at the Department of Opto-Reconstructive and Refractive Corneal Surgery </p><p> Svyatoslava Fedorova str. 5, Kaluga 248007, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0839-2876</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демьянченко</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Demianchenko</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p> кандидат медицинских наук, заведующий отделением оптико-реконструктивной и рефракционной хирургии роговицы, </p><p>248007, г. Калуга, ул. Святослава Фёдорова, 5, Россия</p></bio><bio xml:lang="en"><p> Cand. Sc. (Med.), Head of the Department of Opto-Reconstructive and Refractive Corneal Surgery </p><p> Svyatoslava Fedorova str. 5, Kaluga 248007, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3629-5077</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вишнякова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vishnyakova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p> врач-офтальмолог отделения оптико-реконструктивной и рефракционной хирургии роговицы</p><p>248007, г. Калуга, ул. Святослава Фёдорова, 5, Россия</p></bio><bio xml:lang="en"><p> Ophthalmologist at the Department of Opto-Reconstructive and Refractive Corneal Surgery </p><p> Svyatoslava Fedorova str. 5, Kaluga 248007, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Калужский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» имени академика С.Н. Фёдорова» Минздрава России</institution></aff><aff xml:lang="en"><institution>Kaluga Branch of the S. Fyodorov Eye Microsurgery Federal State Institution </institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2021</year></pub-date><volume>6</volume><issue>6-1</issue><fpage>229</fpage><lpage>236</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Терещенко А.В., Трифаненкова И.Г., Голубева Ю.Ю., Демьянченко С.К., Вишнякова Е.Н., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Терещенко А.В., Трифаненкова И.Г., Голубева Ю.Ю., Демьянченко С.К., Вишнякова Е.Н.</copyright-holder><copyright-holder xml:lang="en">Tereshchenko A.V., Trifanenkova I.G., Golubeva Y.Y., Demianchenko S.K., Vishnyakova E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3130">https://www.actabiomedica.ru/jour/article/view/3130</self-uri><abstract><p>Для лечения прогрессирующего кератоконуса на ранних стадиях в настоящее время активно применяют кросслинкинг роговичного коллагена. В основе данной методики лежит стабилизация патологического процесса за счёт повышения биомеханических свойств собственной роговицы. Толщина роговицы менее 400 мкм в значительной мере ограничивает возможность проведения стандартной процедуры кросслинкинга.В статье проанализированы литературные данные по применению различных методик роговичного кросслинкинга при толщине роговицы менее 400 мкм, которая в значительной мере ограничивает возможности стандартной п роцедуры. Как известно, при проведении кросслинкинга на начальном этапе выполняется деэпителизация роговицы, что в послеоперационном периоде приводит к выраженному корнеальному синдрому. Это определило направление первых модификаций методики, связанных с применением частичной деэпителизацией или полным её отсутствием. Позднее при кросслинкинге «тонких» роговиц активно стали применять методики с использованием дополнительных покровных материалов с целью восполнения недостающей роговичной ткани пациента при проведении процедуры ультрафиолетового облучения. Среди них применение мягкой контактной линзы без ультрафиолетового фильтра, использование роговичной лентикулы, получаемой после проведения операции SMILE, использование защитного лоскута донорской роговицы, получаемого при помощи фемтосекундного лазера из остаточной стромы роговичного диска после проведения трансплантации десцеметовой мембраны или задней послойной кератопластики. Перспективным направлением является разработка и дальнейшее внедрение в клиническую практику принципиально новых кератопротекторов, способных увеличивать толщину роговицы пациента. Многообразие предложенных модификаций и продолжающийся поиск более совершенных вариантов свидетельствует о востребованности данной технологии и необходимости дальнейших изысканий с учётом индивидуальных особенностей эктазии пациента.</p></abstract><trans-abstract xml:lang="en"><p>For the treatment of progressive keratoconus in the early stages, corneal collagen crosslinking is currently actively used. This technique is based on the stabilization of the pathological process by increasing the biomechanical properties of the own cornea. The thickness of the cornea less than 400 microns significantly limits the possibility of a standard cross-linking procedure performing.The article analyzes the literature data on the use of various methods of corneal crosslinking with a corneal thickness of less than 400 microns, which signifi cantly limits the possibilities of the standard procedure.It is known, that during crosslinking, at the initial stage, de-epithelialization of the cornea is performed, which, in the postoperative period, leads to a pronounced corneal syndrome. This determined the direction of the fi rst modifi cations of the technique associated with the use of partial de-epithelialization or its complete absence. Later, during cross-linking of “thin” corneas, techniques with the use of additional covering materials were actively used in order to replenish the missing corneal tissue of the patient during the UV irradiation procedure. Among them are the use of a soft contact lens without an ultraviolet fi lter, the use of a corneal lenticule obtained after SMILE surgery, the use of a protective fl ap of the donor cornea obtained using a femtosecond laser from the residual stroma of the corneal disc after descemet membrane transplantation or posterior lamellar keratoplasty. The variety of the proposed modifications and the ongoing search for better options indicate the demand for this technology and the need for further research, taking into account the individual characteristics of the patient’s ectasia.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кератоконус</kwd><kwd>тонкая роговица</kwd><kwd>ультрафиолетовый кросслинкинг роговичного коллагена</kwd></kwd-group><kwd-group xml:lang="en"><kwd>keratoconus</kwd><kwd>thin cornea</kwd><kwd>ultraviolet corneal collagen crosslinking</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998; 42(4): 297-319. doi: 10.1016/s0039-6257(97)00119-7</mixed-citation><mixed-citation xml:lang="en">Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998; 42(4): 297-319. doi: 10.1016/s0039-6257(97)00119-7</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бикбов М.М., Бикбова Г.М. Эктазии роговицы. М.: Офтальмология; 2011.</mixed-citation><mixed-citation xml:lang="en">Bikbov MM, Bikbova GM. Corneal ectasia. Moscow: Ophthalmology; 2011. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wheeler J, Hauser MA, Afshari NA, Allingham RR, Liu Y. The genetics of keratoconus: A review. Reprod Sys Sex Disord. 2012; 6: 001. doi: 10.4172/2161-038X.S6-001</mixed-citation><mixed-citation xml:lang="en">Wheeler J, Hauser MA, Afshari NA, Allingham RR, Liu Y. The genetics of keratoconus: A review. Reprod Sys Sex Disord. 2012; 6: 001. doi: 10.4172/2161-038X.S6-001</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon-Shaag A, Millodot M, Shneor E, Liu Y. The genetic and environmental factors for keratoconus. Biomed Res Int. 2015; 2015: 795738. doi: 10.1155/2015/795738</mixed-citation><mixed-citation xml:lang="en">Gordon-Shaag A, Millodot M, Shneor E, Liu Y. The genetic and environmental factors for keratoconus. Biomed Res Int. 2015; 2015: 795738. doi: 10.1155/2015/795738</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Zadnik K, Barr JT, Edrington TB, Everett DF, Jameson M, McMahon TT, et al. Baseline fi ndings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study. Invest Ophthalmol Vis Sci. 1998; 39(13): 2537-2546.</mixed-citation><mixed-citation xml:lang="en">Zadnik K, Barr JT, Edrington TB, Everett DF, Jameson M, McMahon TT, et al. Baseline fi ndings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study. Invest Ophthalmol Vis Sci. 1998; 39(13): 2537-2546.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">WollensakG, SpoerlE, SeilerT. Riboflavin/ultraviolet-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003; 135(5): 620-627. doi: 10.1016/s0002-9394(02)02220-1</mixed-citation><mixed-citation xml:lang="en">WollensakG, SpoerlE, SeilerT. Riboflavin/ultraviolet-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003; 135(5): 620-627. doi: 10.1016/s0002-9394(02)02220-1</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Бикбов М.М., Халимов А.Р., Усубов Э.Л. Ультрафиолетовый кросслинкинг роговицы. Вестник Российской академии медицинских наук. 2016; 71(3): 224-232. doi: 10.15690/vramn562</mixed-citation><mixed-citation xml:lang="en">Bikbov MM, Khalimov AR, Usubov EL. Ultraviolet corneal crosslinking. Annals of the Russian Academy of Medical Sciences. 2016; 71(3): 224-232. (In Russ.). doi: 10.15690/vramn562</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Deshmukh R, Hafezi F, Kymionis GD, Kling S, Shah R, Padmanabhan P, et al. Current concepts in crosslinking thin corneas. Indian J Ophthalmol. 2019; 67(1): 8-15. doi: 10.4103/ijo.IJO_1403_18</mixed-citation><mixed-citation xml:lang="en">Deshmukh R, Hafezi F, Kymionis GD, Kling S, Shah R, Padmanabhan P, et al. Current concepts in crosslinking thin corneas. Indian J Ophthalmol. 2019; 67(1): 8-15. doi: 10.4103/ijo.IJO_1403_18</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Солодкова Е.Г., Фокин В.П. Опыт применения модифицированной методики лечения прогрессирующего кератоконуса на основе кросслинкинга роговичного коллагена с фемтосекундным формированием интрастромального кармана. Саратовский научно-медицинский журнал. 2017; 13(2): 431-434.</mixed-citation><mixed-citation xml:lang="en">Solodkova YeG, Fokin VP. Experience of using a modified technique for treating progressive keratoconus based on corneal collagen crosslinking with femtosecond formation of an intrastromal pocket. Saratov Journal of Medical Scientifi c Research. 2017; 13(2): 431-434. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg. 2003; 29(9): 1786-1790. doi: 10.1016/s0886-3350(03)00343-2</mixed-citation><mixed-citation xml:lang="en">Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg. 2003; 29(9): 1786-1790. doi: 10.1016/s0886-3350(03)00343-2</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Schumacher S, Oeftiger L, Mrochen M. Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation. Invest Ophthalmol Vis Sci. 2011; 52(12): 9048-9052. doi: 10.1167/iovs.11-7818</mixed-citation><mixed-citation xml:lang="en">Schumacher S, Oeftiger L, Mrochen M. Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation. Invest Ophthalmol Vis Sci. 2011; 52(12): 9048-9052. doi: 10.1167/iovs.11-7818</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">McQuaid R, Li J, Cummings A, Mrochen M, Vohnsen B. Second-harmonic reflection imaging of normal and accelerated corneal crosslinking using porcine corneas and the role of intraocular pressure. Cornea. 2014; 33(2): 125-130. doi: 10.1097/ICO.0000000000000015</mixed-citation><mixed-citation xml:lang="en">McQuaid R, Li J, Cummings A, Mrochen M, Vohnsen B. Second-harmonic reflection imaging of normal and accelerated corneal crosslinking using porcine corneas and the role of intraocular pressure. Cornea. 2014; 33(2): 125-130. doi: 10.1097/ICO.0000000000000015</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Famose F. Evaluation of accelerated collagen cross-linking for the treatment of melting keratitis in ten cats. Vet Ophthalmol. 2015; 18(2): 95-104. doi: 10.1111/vop.12112</mixed-citation><mixed-citation xml:lang="en">Famose F. Evaluation of accelerated collagen cross-linking for the treatment of melting keratitis in ten cats. Vet Ophthalmol. 2015; 18(2): 95-104. doi: 10.1111/vop.12112</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимов С.И., Анисимова С.Ю., Золоторевский К.А. Динамика изменения остроты зрения и топографических параметров после проведения персонализированного (локального) кросслинкинга. Современные технологии катарактальной и рефракционной хирургии – 2011: Сборник научных статей. М.; 2011: 308-310.</mixed-citation><mixed-citation xml:lang="en">Anisimov SI, Anisimova SYu, Zolotorevskiy KA. Dynamics of changes in visual acuity and topographic parameters after personalized (local) crosslinking. Sovremennye tekhnologii kataraktal’noy i refraktsionnoy khirurgii – 2011: Sbornik nauchnykh statey. Moscow; 2011: 308-310. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wollensak G, Spoerl E, Wilsch M, Seiler T. Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment. Cornea. 2004; 23(1): 43-49. doi: 10.1097/00003226-200401000-00008</mixed-citation><mixed-citation xml:lang="en">Wollensak G, Spoerl E, Wilsch M, Seiler T. Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment. Cornea. 2004; 23(1): 43-49. doi: 10.1097/00003226-200401000-00008</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Filippello M, Stagni E, O’Brart D. Transepithelial corneal collagen crosslinking: Bilateral study. J Cataract Refract Surg. 2012; 38(2): 283-291. doi: 10.1016/j.jcrs.2011.08.030</mixed-citation><mixed-citation xml:lang="en">Filippello M, Stagni E, O’Brart D. Transepithelial corneal collagen crosslinking: Bilateral study. J Cataract Refract Surg. 2012; 38(2): 283-291. doi: 10.1016/j.jcrs.2011.08.030</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pinelli R, Marzouky MM, El-Shawaf HI. Tensoactive-mediated transepithelial corneal cross-linking – first laboratory report. European Ophthalmic Review. 2009; 3(2): 67-70.</mixed-citation><mixed-citation xml:lang="en">Pinelli R, Marzouky MM, El-Shawaf HI. Tensoactive-mediated transepithelial corneal cross-linking – first laboratory report. European Ophthalmic Review. 2009; 3(2): 67-70.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Pinelli R. C3-R treatment opens new frontiers for keratoconus and corneal ectasia. Eyeword. 2007; 34: 36-39.</mixed-citation><mixed-citation xml:lang="en">Pinelli R. C3-R treatment opens new frontiers for keratoconus and corneal ectasia. Eyeword. 2007; 34: 36-39.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Leccisotti A, Islam T. Transepithelial corneal collagen cross-linking in keratoconus. J Refract Surg. 2010; 26(12): 942-948. doi: 10.3928/1081597x-20100212-09</mixed-citation><mixed-citation xml:lang="en">Leccisotti A, Islam T. Transepithelial corneal collagen cross-linking in keratoconus. J Refract Surg. 2010; 26(12): 942-948. doi: 10.3928/1081597x-20100212-09</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bikbova G, Bikbov M. Transepithelial corneal collagen cross-linking by iontophoresis of riboflavin. Acta Ophthalmologica. 2013; 92(1): e30-e34. doi: 10.1111/aos.12235</mixed-citation><mixed-citation xml:lang="en">Bikbova G, Bikbov M. Transepithelial corneal collagen cross-linking by iontophoresis of riboflavin. Acta Ophthalmologica. 2013; 92(1): e30-e34. doi: 10.1111/aos.12235</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lombardo M, Giannini D, Lombardo G, Serrao S. Randomized controlled trial comparing transepithelial corneal crosslinking using iontophoresis with the Dresden protocol in progressive keratoconus. Ophthalmology. 2017; 124(6): 804-812. doi: 10.1016/j.ophtha.2017.01.040</mixed-citation><mixed-citation xml:lang="en">Lombardo M, Giannini D, Lombardo G, Serrao S. Randomized controlled trial comparing transepithelial corneal crosslinking using iontophoresis with the Dresden protocol in progressive keratoconus. Ophthalmology. 2017; 124(6): 804-812. doi: 10.1016/j.ophtha.2017.01.040</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Cassagne M, Laurent C, Rodrigues M, Galinier A, Spoerl E, Galiacy SD, et al. Iontophoresis transcorneal delivery technique for transepithelial corneal collagen crosslinking with riboflavin in a rabbit model. Invest Ophthalmol Vis Sci. 2016; 57(2): 594-613. doi: 10.1167/iovs.13-12595</mixed-citation><mixed-citation xml:lang="en">Cassagne M, Laurent C, Rodrigues M, Galinier A, Spoerl E, Galiacy SD, et al. Iontophoresis transcorneal delivery technique for transepithelial corneal collagen crosslinking with riboflavin in a rabbit model. Invest Ophthalmol Vis Sci. 2016; 57(2): 594-613. doi: 10.1167/iovs.13-12595</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Jouve L, Borderie V, Sandali O, Temstet C, Basli E, Laroche L, et al. Conventional and iontophoresis corneal cross-linking for keratoconus: Efficacy and assessment by optical coherence tomography and confocal microscopy. Cornea. 2017; 36(2): 153-162. doi: 10.1097/ICO.0000000000001062</mixed-citation><mixed-citation xml:lang="en">Jouve L, Borderie V, Sandali O, Temstet C, Basli E, Laroche L, et al. Conventional and iontophoresis corneal cross-linking for keratoconus: Efficacy and assessment by optical coherence tomography and confocal microscopy. Cornea. 2017; 36(2): 153-162. doi: 10.1097/ICO.0000000000001062</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Krueger RR, Ramos-Esteban JC, Kannellopoulos AJ. Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullos keratopathy: Laboratory investigation and first clinical case. J Refract Surg. 2008; 24(7): S730-S736. doi: 10.3928/1081597X-20080901-17</mixed-citation><mixed-citation xml:lang="en">Krueger RR, Ramos-Esteban JC, Kannellopoulos AJ. Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullos keratopathy: Laboratory investigation and first clinical case. J Refract Surg. 2008; 24(7): S730-S736. doi: 10.3928/1081597X-20080901-17</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Паштаев Н.П., Зотов В.В. Сравнительный анализ отдаленных результатов стандартного и локального фемтокросслинкинга у больных с прогрессирующим кератоконусом. Вестник ОГУ. 2014; 12(173): 248-251.</mixed-citation><mixed-citation xml:lang="en">Pashtayev NP, Zotov VV. Comparative analysis of long-term results of standard and local femto-crosslinking in patients with progressive keratoconus. Vestnik of Orenburg State University. 2014; 12(173): 248-251. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kymionis G, Diakonis V, Coskunseven E, Jankov M, Yoo SH, Pallikaris IG. Customized pachymetric guided epithelial debridement for corneal collagen cross linking. BMC Ophthalmol. 2009; 9: 10. doi: 10.1186/1471-2415-9-10</mixed-citation><mixed-citation xml:lang="en">Kymionis G, Diakonis V, Coskunseven E, Jankov M, Yoo SH, Pallikaris IG. Customized pachymetric guided epithelial debridement for corneal collagen cross linking. BMC Ophthalmol. 2009; 9: 10. doi: 10.1186/1471-2415-9-10</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mazzotta C, Ramovecchi V. Customized epithelial debridement for thin ectatic corneas undergoing corneal crosslinking: Epithelial Island cross-linking technique. Clin Ophthalmol Auckl NZ. 2014; 8: 1337-1343. doi: 10.2147/OPTH.S66372</mixed-citation><mixed-citation xml:lang="en">Mazzotta C, Ramovecchi V. Customized epithelial debridement for thin ectatic corneas undergoing corneal crosslinking: Epithelial Island cross-linking technique. Clin Ophthalmol Auckl NZ. 2014; 8: 1337-1343. doi: 10.2147/OPTH.S66372</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cagil N, Sarac O, Can G, Akcay E, Can M. Outcomes of corneal collagen crosslinking using a customized epithelial debridement technique in keratoconic eyes with thin corneas. Int Ophthalmol. 2017; 37(1): 103-109. doi: 10.1007/s10792-016-0234-3</mixed-citation><mixed-citation xml:lang="en">Cagil N, Sarac O, Can G, Akcay E, Can M. Outcomes of corneal collagen crosslinking using a customized epithelial debridement technique in keratoconic eyes with thin corneas. Int Ophthalmol. 2017; 37(1): 103-109. doi: 10.1007/s10792-016-0234-3</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kaya V, Utine C, Yilmaz O. Efficacy of corneal collagen cross-linking using a custom epithelial debridement technique in thin corneas: A confocal microscopy study. J Refract Surg. 2011; 27(6): 444-450. doi: 10.3928/1081597X-20101201-01</mixed-citation><mixed-citation xml:lang="en">Kaya V, Utine C, Yilmaz O. Efficacy of corneal collagen cross-linking using a custom epithelial debridement technique in thin corneas: A confocal microscopy study. J Refract Surg. 2011; 27(6): 444-450. doi: 10.3928/1081597X-20101201-01</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Малюгин Б.Э., Измайлова С.Б., Шацких А.В., Мерзлов Д.Е., Пронкина С.А. Экспериментальное обоснование эффективности различных методов доставки рибофлавина в строму роговицы как начального этапа выполнения УФкросслинкинга. Офтальмохирургия. 2014; 1: 24-29.</mixed-citation><mixed-citation xml:lang="en">Malyugin BE, Izmaylova SB, Shatskikh AV, Merzlov DE, Pronkina SA. Experimental substantiation of the effectiveness of various methods of ribofl avin delivery to the corneal stroma as the initial stage of UV crosslinking. Fyodorov Journal of Ophthalmic Surgery. 2014; 1: 24-29. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Солодкова Е.Г., Фокин В.П., Балалин С.В., Мелихова И.А. Эффективность и безопасность кросслинкинга роговичного коллагена при лечении прогрессирующего кератоконуса. Вестник ВолГМУ. 2017; 2(62): 91-94.</mixed-citation><mixed-citation xml:lang="en">Solodkova YeG, Fokin VP, Balalin SV, Melikhova IA. Efficacy and safety of corneal collagen crosslinking in the treatment of progressive keratoconus. Journal of VolgSMU. 2017; 2(62): 91-94. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Искаков И.А., Костенев С.В., Черных В.В. Новый метод выполнения кросслинкинга роговичного коллагена у пациентов с тонкой роговицей. Современные технологии катарактальной и рефракционной хирургии: Сборник XIV научно-практической конференции. М.; 2013: 228-232.</mixed-citation><mixed-citation xml:lang="en">Iskakov IA, Kostenev SV, Chernykh VV. A new method for performing corneal collagen crosslinking in patients with a thin cornea. Sovremennyye tekhnologii kataraktal’noy i refraktsionnoy khirurgii: Sbornik XIV nauchno-prakticheskoy konferentsii. Moscow; 2013: 228-232. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Jacob S, Kumar D, Agarwal A, Basu S, Sinha P, Agarwal A. Contact lens-assisted collagen cross-linking (CACXL): A new technique for cross-linking thin corneas. J Refract Surg. 2014; 30(6): 366-372. doi: 10.3928/1081597X-20140523-01</mixed-citation><mixed-citation xml:lang="en">Jacob S, Kumar D, Agarwal A, Basu S, Sinha P, Agarwal A. Contact lens-assisted collagen cross-linking (CACXL): A new technique for cross-linking thin corneas. J Refract Surg. 2014; 30(6): 366-372. doi: 10.3928/1081597X-20140523-01</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева И.В., Егоров В.В., Васильев А.В. Анализ эффективности и безопасности кросслинкинга роговичного коллагена у пациентов с толщиной роговицы менее 400 мкм после деэпителизации с применением донорской роговичной лентикулы. Практическая медицина. 2017; 9: 110.</mixed-citation><mixed-citation xml:lang="en">Vasil’yeva IV, Yegorov VV, Vasil’yev AV. Analysis of the efficacy and safety of corneal collagen crosslinking in patients with corneal thickness less than 400 μm after deepithelialization using a donor corneal lenticule. Practical Medicine. 2017; 9: 110. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sachdev M, Gupta D, Sachdev G, Sachdev R. Tailored stromal expansion with a refractive lenticule for crosslinking the ultrathin cornea. J Cataract Refract Surg. 2015; 41(5): 918-923. doi: 10.1016/j.jcrs.2015.04.007</mixed-citation><mixed-citation xml:lang="en">Sachdev M, Gupta D, Sachdev G, Sachdev R. Tailored stromal expansion with a refractive lenticule for crosslinking the ultrathin cornea. J Cataract Refract Surg. 2015; 41(5): 918-923. doi: 10.1016/j.jcrs.2015.04.007</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Голубева Ю.Ю., Терещенко А.В., Трифаненкова И.Г., Вишнякова Е.Н., Демьянченко С.К. Методика ультрафиолетового кросслинкинга в лечении прогрессирующего кератоконуса при «тонкой роговице». Современные технологии в офтальмологии. 2019; (4): 59-62. doi: 10.25276/2312-4911-2019-4-59-62</mixed-citation><mixed-citation xml:lang="en">Golubeva YY, Tereshchenko AV, Trifanenkova IG, Vishnyakova YeN, Dem’yanchenko SK. Ultraviolet crosslinking technique in the treatment of progressive keratoconus with a “thin cornea”. Modern Technologies in Ophthalmology. 2019; (4): 59-62. (In Russ.). doi: 10.25276/2312-4911-2019-4-59-62</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Халимов А.Р., Катаев В.А., Дроздова Г.А., Казакбаева Г.М., Халиков Р.А. Результаты ex vivo исследования нового офтальмологического средства для рибофлавина-УФ-А индуцированного сшивания коллагена тонких роговиц. Экспериментальная и клиническая фармакология. 2018; 81(2): 30-32.</mixed-citation><mixed-citation xml:lang="en">Khalimov AR, Katayev VA, Drozdova GA, Kazakbayeva GM, Khalikov RA. Results of an ex vivo study of a new ophthalmic agent for riboflavin-UV-A-induced collagen cross-linking of thin corneas. Eksperimental’naya i klinicheskaya farmakologiya = Experimental and Clinical Pharmacology. 2018; 81(2): 30-32. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Бикбов М.М., Суркова В.К., Казакбаева Г.М. Конфокальная микроскопия при кератоконусе после одномоментной имплантации колец myoring и кросслинкинга роговицы. Точка зрения. Восток-Запад. 2021; 1: 21-25.</mixed-citation><mixed-citation xml:lang="en">Bikbov MM, Surkova VK, Kazakbayeva GM. Confocal microscopy in keratoconus after simultaneous implantation of myoring rings and corneal crosslinking. Point of View. East-West. 2021; 1: 21-25. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang JS, Lee JH, Wee WR, Kim MK. Effect sofmulticurve RGP contact lensuse on topographic changes in keratoconus. Korean J Ophthalmol. 2010; 24(4): 201-206. doi: 10.3341/kjo.2010.24.4.201</mixed-citation><mixed-citation xml:lang="en">Hwang JS, Lee JH, Wee WR, Kim MK. Effect sofmulticurve RGP contact lensuse on topographic changes in keratoconus. Korean J Ophthalmol. 2010; 24(4): 201-206. doi: 10.3341/kjo.2010.24.4.201</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Mark HH. Keratoconus appearing after contact lens wear. Eye Ear Nose Throat Mon. 1974; 53(6): 225-226.</mixed-citation><mixed-citation xml:lang="en">Mark HH. Keratoconus appearing after contact lens wear. Eye Ear Nose Throat Mon. 1974; 53(6): 225-226.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Аляева О.О., Рябенко О.И., Тананакина Е.М., Юшкова И.С. Опыт применения склеральных линз Zenlens для зрительной реабилитации пациентов с иррегулярной роговицей. Российский офтальмологический журнал. 2018; 11(4): 68-74</mixed-citation><mixed-citation xml:lang="en">Alyayeva OO, Ryabenko OI, Tananakina YeM, Yushkova IS. Experience of using Zenlens scleral lenses for visual rehabilitation of patients with irregular cornea. Russian Ophthalmological Journal. 2018; 11(4): 68-74. (In Russ.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
