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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2021-6.6-1.23</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3127</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPHTHALMOLOGY</subject></subj-group></article-categories><title-group><article-title>Способ двухэтапного лечения аметропии у пациентов с кератоконусом и катарактой</article-title><trans-title-group xml:lang="en"><trans-title>Two-stage treatment of ametropia in patients with keratoconus and cataracts</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9476-8883</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бикбов</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bikbov</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, профессор, член-корреспондент Академии наук Республики Башкортостан, директор</p><p> 450008, Башкортостан, г. Уфа, ул. Пушкина, 90, Россия </p></bio><bio xml:lang="en"><p> Dr. Sc. (Med.), Professor, Corresponding Member of the Academy of Sciences of the Republic of Bashkortostan, Director</p><p> Pushkina str. 90, Ufa 450008, Bashkortostan, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6815-8208</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оренбуркина</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Orenburkina</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p> кандидат медицинских наук, заведующая лабораторией хирургии хрусталика и интраокулярной коррекции</p><p> 450008, Башкортостан, г. Уфа, ул. Пушкина, 90, Россия </p></bio><bio xml:lang="en"><p> Cand. Sc. (Med.), Head of the Laboratory of Lens Surgery and Intraocular Correction </p><p> Pushkina str. 90, Ufa 450008, Bashkortostan, Russian Federation </p></bio><email xlink:type="simple">linza7@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабушкин</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Babushkin</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, заведующий отделом научных исследований  </p><p> 450008, Башкортостан, г. Уфа, ул. Пушкина, 90, Россия </p></bio><bio xml:lang="en"><p> Dr. Sc. (Med.), Head of the Research Department </p><p> Pushkina str. 90, Ufa 450008, Bashkortostan, Russian Federation </p></bio><email xlink:type="simple">virologicdep@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуриев</surname><given-names>И. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Nuriev</surname><given-names>I. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p> врач-офтальмолог II микрохирургического отделения</p><p> 450008, Башкортостан, г. Уфа, ул. Пушкина, 90, Россия </p></bio><bio xml:lang="en"><p> Ophthalmologist at the 2nd Microsurgical Department </p><p> Pushkina str. 90, Ufa 450008, Bashkortostan, Russian Federation </p></bio><email xlink:type="simple">ildar192009@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУ «Уфимский научно-исследовательский институт глазных болезней Академии наук Республики Башкортостан»</institution></aff><aff xml:lang="en"><institution>Ufa Eye Research Institute</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2021</year></pub-date><volume>6</volume><issue>6-1</issue><fpage>204</fpage><lpage>213</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бикбов М.М., Оренбуркина О.И., Бабушкин А.Э., Нуриев И.Ф., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Бикбов М.М., Оренбуркина О.И., Бабушкин А.Э., Нуриев И.Ф.</copyright-holder><copyright-holder xml:lang="en">Bikbov M.M., Orenburkina O.I., Babushkin A.E., Nuriev I.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3127">https://www.actabiomedica.ru/jour/article/view/3127</self-uri><abstract><p>Кератоконус (КК) является прогрессирующим дегенеративным заболеванием роговицы, приводящим к нарушению её биомеханических и оптических свойств, её истончению, появлению астигматизма и снижению остроты зрения.Материалы и методы. Представлено наблюдение за 33 больными (35 глаз) с кератоконусом 2–3-й стадии на фоне имеющейся катаракты. Средний возраст пациентов – 46,5 ± 2,7 года (41–63 лет). Операции проводились по предложенному нами двухэтапному способу лечения аметропии у пациентов с КК и катарактой (Патент РФ № 2748634 от 28.05.2021). Первым этапом имплантировали интрароговичные сегменты (ИРС) FERRARA толщиной от 150 до 350 мкм, через 5–7 месяцев после 1-го этапа с целью коррекции остаточной аметропии пациентам проводили 2-й этап – удаление мутного хрусталика с заме ной его на искусственный – заднекамерную торическую интраокулярную линзу (ТИОЛ). Имплантировали следующие модели ТИОЛ: AcrySof IQ Toric (Alcon, США), T-fl ex, RayOne Toric (Rayner, Великобритания).Результаты и обсуждение. После первого этапа операции (имплантации ИРС) некорригированная острота зрения (НКОЗ) составила 0,2 ± 0,03, максимально корригированная (МКОЗ) – 0,4 ± 0,02. НКОЗ через 1 мес. после 2-го этапа (ФЭК + ТИОЛ) составила 0,64 ± 0,11, МКОЗ – 0,74 ± 0,12. В течение всего срока наблюдения после операции отмечались стабильные зрительные функции, рефракция, а также ротационная стабильность ТИОЛ.Выводы. Проведение двухэтапного хирургического вмешательства пациентам с кератоконусом и катарактой позволяет приостановить прогрессирование заболевания и эффективно скорректировать сопутствующую кератоконусу аметропию.</p></abstract><trans-abstract xml:lang="en"><p>Keratoconus (KC) is a progressive degenerative corneal disease, leads to the aberration of biomechanical and optical properties and thinning of the cornea, causes astigmatism and decreases visual acuity.Materials and methods. 33 patients (35 eyes) with stages II–III of non-progressive keratoconus and concomitant cataracts of various stages of maturity were operated on. The average age of the patients was 46.5 ± 2.7 (41–63) years old. The operations were performed according to our proposed two-stage method of treating ametropia in patients with KC and cataracts (Patent of the Russian Federation No. 2748634 of 28.05.2021). The first stage was the implantation of FERRARA intrastromal corneal ring segments (ICRS) with thickness from 150 to 350 μm. To correct residual refractive error in 5–7 months after stage 1, patients underwent stage 2: cloudy lens was removed and replaced with toric posterior chamber intraocular lens (TIOL) – AcrySof IQ Toric (Alcon, USA), T-fl ex Toric RayOne (Rayner, UK).Results and discussion. After stage 1 of the operation (ICRS implantation), the uncorrected visual acuity (NCVA) was 0.2 ± 0.03, the best corrected visual acuity (BCVA) was 0.4 ± 0.02. In 1 month after stage 2 (phacoemulsifi cation + TIOL) NCVA was 0.64 ± 0.11 and BCVA was 0.74 ± 0.12. During the entire follow-up period after the surgery visual functions, refraction, and rotational stability of TIOL were stable.Conclusions. Conducting a two-stage surgical intervention in patients with keratoconus and cataracts allows to stop the progression of the disease and effectively correct the ametropia concomitant with keratoconus.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кератоконус</kwd><kwd>катаракта</kwd><kwd>интрароговичные сегменты</kwd><kwd>аметропия</kwd><kwd>торические интраокулярные линзы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>keratoconus</kwd><kwd>cataract</kwd><kwd>intracorneal segments</kwd><kwd>ametropia</kwd><kwd>toric intraocular lenses</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бикбов М.М., Бикбова Г.М., Хабибуллин А.Ф. Кросслинкинг роговичного коллагена в лечении кератоконуса. Вестник офтальмологии. 2011; 127(5): 21-25.</mixed-citation><mixed-citation xml:lang="en">Bikbov MM, Bikbova GM, Khabibullin AF. Corneal collagen cross-linking in keratoconus management. 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