<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2021-6.5.21</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3053</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SURGERY</subject></subj-group></article-categories><title-group><article-title>Непосредственные результаты операций повторного коронарного шунтирования из минидоступов на работающем сердце</article-title><trans-title-group xml:lang="en"><trans-title>Immediate results of minimally invasive redo off-pump coronary artery bypass grafting</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3465-792X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подкаменный</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Podkamenniy</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры сердечно-сосудистой хирургии, 664049, Иркутск, Юбилейный, 100;</p><p>сердечно-сосудистый хирург кардиохирургического отделения № 1, 664049, г. Иркутск, Юбилейный, 100</p></bio><bio xml:lang="en"><p>Dr.  Sc. (Med.), Professor at the Department of Cardiovascular Surgery;</p><p>Cardiovascular Surgeon at the Cardiac Surgery Unit No. 1,</p><p>Yubileyniy 100, Irkutsk 664049</p></bio><email xlink:type="simple">pvdm@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1073-1213</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаравин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharavin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>сердечно-сосудистый хирург кардиохирургического отделения № 1, </p><p>664049, г. Иркутск, Юбилейный, 100</p></bio><bio xml:lang="en"><p>Cardiovascular Surgeon at the Cardiac Surgery Unit, </p><p>Yubileyniy 100, Irkutsk 664049</p></bio><email xlink:type="simple">trew1986@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3692-075X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лиханди</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Likhandi</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>сердечно-сосудистый хирург кардиохирургического отделения №  1, </p><p>664049, г. Иркутск, Юбилейный, 100</p></bio><bio xml:lang="en"><p>Cardiovascular Surgeon at the Cardiac Surgery Unit,</p><p>Yubileyniy 100, Irkutsk 664049</p></bio><email xlink:type="simple">trew1986@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Желтовский</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zheltovsky</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой сердечно-сосудистой хирургии, 664049, Иркутск, Юбилейный, 100;</p><p>сердечно-сосудистый хирург кардиохирургического отделения № 1, 664049, г. Иркутск, Юбилейный, 100</p></bio><bio xml:lang="en"><p> Dr. Sc. (Med.), Head of the Department of Cardiovascular Surgery;</p><p> Cardiovascular Surgeon at the Cardiac Surgery Unit No. 1, </p><p>Yubileyniy 100, Irkutsk 664049</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6474-2917</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вырупаев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vyrupaev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кардиолог кардиохирургического отделения № 1, </p><p>664049, г. Иркутск, Юбилейный, 100</p></bio><bio xml:lang="en"><p>Cardiologist at the Cardiac Surgery Unit No. 1, </p><p>Yubileyniy 100, Irkutsk 664049</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России;&#13;
ГБУЗ Иркутская ордена «Знак почёта» областная клиническая больница</institution></aff><aff xml:lang="en"><institution>Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education;&#13;
Irkutsk Regional Clinical Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ Иркутская ордена «Знак почёта» областная клиническая больница</institution></aff><aff xml:lang="en"><institution>Irkutsk Regional Clinical Hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>22</day><month>11</month><year>2021</year></pub-date><volume>6</volume><issue>5</issue><fpage>222</fpage><lpage>229</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Подкаменный В.А., Шаравин А.А., Лиханди Д.И., Желтовский Ю.В., Вырупаев А.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Подкаменный В.А., Шаравин А.А., Лиханди Д.И., Желтовский Ю.В., Вырупаев А.В.</copyright-holder><copyright-holder xml:lang="en">Podkamenniy V.A., Sharavin A.A., Likhandi D.I., Zheltovsky Y.V., Vyrupaev A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3053">https://www.actabiomedica.ru/jour/article/view/3053</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Ишемическая болезнь сердца (ИБС) занимает первое место среди причин смерти от кардиальных событий. Пациенты, которым ранее выполнено оперативное лечение – коронарное шунтирование (КШ), – не  застрахованы от возврата стенокардии в связи с прогрессированием атеросклероза в нативных коронарных артериях либо дегенеративными изменениями в шунтах. Поэтому вопрос повторного вмешательства в данной группе пациентов является дискутабельным.</p></sec><sec><title>Цель работы</title><p>Цель работы. Показать, что использование альтернативных стернотомии доступов и отказ от искусственного кровообращения рассматриваются как возможные мероприятия по улучшению результатов повторных коронарных шунтирований.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В отделении кардиохирургии №  1 ГБУЗ Иркутской ордена «Знак почёта» областной клинической больницы с 2003 по  2020  г. выполнено 6773  операции КШ на «работающем сердце». Из них 6338 (93,6 %) операций выполнены доступом через срединную стернотомию и  435  (6,4  %) – с применением миниторакотомии или субксифоидальным доступом. Из 6338 КШ, выполненных доступом из стернотомии, 58 (0,9 %) операций выполнены повторно. Все повторные операции за рассматриваемый период выполнены из миниторакотомии или субксифоидальным доступом. Показанием к повторной операции являлся возврат не поддающейся оптимальной медикаментозной терапии стенокардии III или IV функциональных классов. 54 операции выполнены доступом через левостороннюю миниторакотомию. У 3 больных КШ выполнено субксифоидальным доступом, у 1 больного – из правосторонней миниторакотомии.</p></sec><sec><title>Результаты</title><p>Результаты. Выполнено 58  операций повторного КШ. Повреждения при доступе отделов сердца или функционирующих шунтов не отмечались. Осложнения отмечены у 5 (8,6 %) больных. В 1 наблюдении потребовалась повторная операция в связи с кровотечением из межрёберной артерии. В остальных случаях наблюдались нарушения ритма либо необходимость в инотропной поддержке.</p></sec><sec><title>Заключение</title><p>Заключение. Выполнение повторных операций КШ на «работающем сердце» с использованием минидоступов позволяет снизить риск повреждения сердца и функционирующих шунтов, исключить манипуляции на восходящем отделе аорты, избежать сложности с кардиоплегической защитой миокарда при функционирующем маммарокоронраном шунте. </p></sec></abstract><trans-abstract xml:lang="en"><p>Coronary heart disease (CHD) ranks first among the causes of death from cardiac events. Patients who have previously undergone surgical treatment – coronary artery bypass grafting (CABG) – are not immune from the return of angina due to the progression of atherosclerosis in the native coronary arteries or degenerative changes in the shunts. Therefore, the issue of redo surgery in this group of patients is debatable.</p><p>The aim of the research is to show that the use of alternative sternotomy approaches and the rejection of artificial blood circulation (ABC) are considered as possible measures to improve the results of redo CABGs.</p><sec><title>Materials and methods</title><p>Materials and methods. In the Cardiac Surgery Unit No. 1 of the Irkutsk Regional Clinical Hospital from 2003 to 2020, 6773 off-pump CABG surgeries were performed. Of these, 6338  (93.6  %) surgeries were performed using median sternotomy and  435  (6.4  %) surgeries were performed using minitoracotomy or subxyphoid access. Of the 6338 CABG surgeries performed using sternotomy, 58 (0.9 %) were performed repeatedly. All redo surgeries during the period under review were performed by minithoracotomy or subxyphoid access. The indication for redo surgery was the return of angina of III or IV functional class, which did not respond to optimal drug therapy. When performing 54 redo surgeries, the access was leftsided mini-thoracotomy. In 3 patients, CABG was performed by subxyphoid access and in 1 patient – from right-sided mini-thoracotomy.</p></sec><sec><title>Results</title><p>Results. 58 redo CABG surgeries were performed. There was no damage to the access of the heart or functioning shunts. Complications were noted in 5 (8.6 %) patients. In 1 case, a second operation was required due to bleeding from the intercostal artery. In other cases, there were rhythm disturbances, or the need for inotropic support.</p></sec><sec><title>Conclusion</title><p>Conclusion. Performing redo off-pump CABG surgeries using mini-accesses reduces the risk of damage to the heart and functioning shunts, eliminates manipulations on the ascending aorta, and avoids difficulties with cardioplegic protection of the myocardium with a functioning mammarocoronary graft. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>повторное коронарное шунтирование</kwd><kwd>минидоступы</kwd><kwd>шунтирование на «работающем сердце»</kwd><kwd>искусственное кровообращение</kwd><kwd>стернотомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>minimally invasive surgery</kwd><kwd>off-pump coronary artery bypass grafting</kwd><kwd>redo surgery</kwd><kwd>artificial blood circulation</kwd><kwd>sternotomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sabik JF, Blackstone EH, Houghtaling PL, Walts PA, Lytle BW. Is reoperation still a risk factor in coronary artery bypass surgery? Ann Thorac Surg. 2005; 80(5): 1719-1727. doi: 10.1016/j.athoracsur.2005.04.033</mixed-citation><mixed-citation xml:lang="en">Sabik JF, Blackstone EH, Houghtaling PL, Walts PA, Lytle BW. Is reoperation still a risk factor in coronary artery bypass surgery? Ann Thorac Surg. 2005; 80(5): 1719-1727. doi: 10.1016/j.athoracsur.2005.04.033</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Подкаменный В.А. Коронарное шунтирование на работающем сердце из минидоступов (MIDCAB) в лечении больных ИБС. Иркутск: РИО ГУ «НЦ РВХ ВСНЦ СО РАМН»; 2006.</mixed-citation><mixed-citation xml:lang="en">Podkamenniy VA. Minimally invasive direct coronary artery bypass (MIDCAB) in the treatment of patients with coronary artery disease. Irkutsk; 2006. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Рекомендации ESC/EACTS по реваскуляризации миокарда 2018. Российский кардиологический журнал. 2019; 24(8): 151-226. doi: 10.15829/1560-4071-2019-8-151-226</mixed-citation><mixed-citation xml:lang="en">2018 ESC/EACTS guidelines on myocardial revascularization. Russian Journal of Cardiology. 2019; 24(8): 151-226. (In Russ.) doi: 10.15829/1560-4071-2019-8-151-226</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brener SJ, Lytle BW, Casserly IP, Ellis SG, Topol EJ, Lauer MS. Predictors of revascularization method and long-term outcome of percutaneous coronary intervention or repeat coronary bypass surgery in patients with multivessel coronary disease and previous coronary bypass surgery. Eur Heart J. 2006; 27(4): 413-418. doi: 10.1093/eurheartj/ehi646</mixed-citation><mixed-citation xml:lang="en">Brener SJ, Lytle BW, Casserly IP, Ellis SG, Topol EJ, Lauer MS. Predictors of revascularization method and long-term outcome of percutaneous coronary intervention or repeat coronary bypass surgery in patients with multivessel coronary disease and previous coronary bypass surgery. Eur Heart J. 2006; 27(4): 413-418. doi: 10.1093/eurheartj/ehi646</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Morrison DA, Sethi G, Sacks J, Henderson WG, Grover F, Sedlis S, et al.; Investigators of the Department of Veterans Affairs Cooperative Study #385, Angina With Extremely Serious Operative Mortality Evaluation. Percutaneous coronary intervention versus repeat bypass surgery for patients with medically refractory myocardial ischemia: AWESOME randomized trial and registry experience with post-CABG patients. J Am Coll Cardiol. 2002; 40(11): 1951-1954. doi: 10.1016/s0735-1097(02)02560-3</mixed-citation><mixed-citation xml:lang="en">Morrison DA, Sethi G, Sacks J, Henderson WG, Grover F, Sedlis S, et al.; Investigators of the Department of Veterans Affairs Cooperative Study #385, Angina With Extremely Serious Operative Mortality Evaluation. Percutaneous coronary intervention versus repeat bypass surgery for patients with medically refractory myocardial ischemia: AWESOME randomized trial and registry experience with post-CABG patients. J Am Coll Cardiol. 2002; 40(11): 1951-1954. doi: 10.1016/s0735-1097(02)02560-3</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Keogh BE, Kinsman R. National Adult Cardiac Surgical Database Report 2000–2001. Henley-on-Thames: Dendrite Clinical Systems Ltd; 2002.</mixed-citation><mixed-citation xml:lang="en">Keogh BE, Kinsman R. National Adult Cardiac Surgical Database Report 2000–2001. Henley-on-Thames: Dendrite Clinical Systems Ltd; 2002.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Yap CH, Sposato L, Akowuah E, Theodore S, Dinh DT, Shardey GC, et al. Contemporary results show repeat coronary artery bypass grafting remains a risk factor for operative mortality. Ann Thorac Surg. 2009; 87(5): 1386-1391. doi: 10.1016/j.athoracsur.2009.02.006</mixed-citation><mixed-citation xml:lang="en">Yap CH, Sposato L, Akowuah E, Theodore S, Dinh DT, Shardey GC, et al. Contemporary results show repeat coronary artery bypass grafting remains a risk factor for operative mortality. Ann Thorac Surg. 2009; 87(5): 1386-1391. doi: 10.1016/j.athoracsur.2009.02.006</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dohi M, Miyata H, Doi K, Okawa K, Motomura N, Takamoto S, et al. The off-pump technique in redo coronary artery bypass grafting reduces mortality and major morbidities: Propensity score analysis of data from the Japan Cardiovascular Surgery Database. Eur J Cardiothorac Surg. 2015; 47(2): 299-307. doi: 10.1093/ejcts/ezu081</mixed-citation><mixed-citation xml:lang="en">Dohi M, Miyata H, Doi K, Okawa K, Motomura N, Takamoto S, et al. The off-pump technique in redo coronary artery bypass grafting reduces mortality and major morbidities: Propensity score analysis of data from the Japan Cardiovascular Surgery Database. Eur J Cardiothorac Surg. 2015; 47(2): 299-307. doi: 10.1093/ejcts/ezu081</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Moralesa D, Williamsb E, Johnc R. Is resternotomy in cardiac surgery still a problem? Interact Cardiovasc Thorac Surg. 2010; 11(3): 277-286. doi: 10.1510/icvts.2009.232090</mixed-citation><mixed-citation xml:lang="en">Moralesa D, Williamsb E, Johnc R. Is resternotomy in cardiac surgery still a problem? Interact Cardiovasc Thorac Surg. 2010; 11(3): 277-286. doi: 10.1510/icvts.2009.232090</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yau TM, Borger MA, Weisel RD, Ivanov J. The changing pattern of reoperative coronary surgery: Trends in 1230 consecutive reoperations. J Thorac Cardiovasc Surg. 2000; 120(1): 156-163. doi: 10.1067/mtc.2000.106983</mixed-citation><mixed-citation xml:lang="en">Yau TM, Borger MA, Weisel RD, Ivanov J. The changing pattern of reoperative coronary surgery: Trends in 1230 consecu- tive reoperations. J Thorac Cardiovasc Surg. 2000; 120(1): 156-163. doi: 10.1067/mtc.2000.106983</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Tugtekin SM, Alexiou K, Kappert U, Esche H, Joskowiak D, Knaut M, et al. Coronary reoperation with and without cardiopulmonary bypass. Clin Res Cardiol. 2006; 95(2): 93-98. doi: 10.1007/s00392-006-0335-5</mixed-citation><mixed-citation xml:lang="en">Tugtekin SM, Alexiou K, Kappert U, Esche H, Joskowiak D, Knaut M, et al. Coronary reoperation with and without cardiopulmonary bypass. Clin Res Cardiol. 2006; 95(2): 93-98. doi: 10.1007/s00392-006-0335-5</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ungerleider RM, Mills ML, Wechsler AS. Left thoracotomy for reoperative coronary artery bypass procedures. Ann Thorac Surg. 1985; 40(1): 11-15. doi: 10.1016/s0003-4975(10)61160-5</mixed-citation><mixed-citation xml:lang="en">Ungerleider RM, Mills ML, Wechsler AS. Left thoracotomy for reoperative coronary artery bypass procedures. Ann Thorac Surg. 1985; 40(1): 11-15. doi: 10.1016/s0003-4975(10)61160-5</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Walker WS, Sang CTM. Avoidance of patent anterior grafts at revisional coronary artery surgery: Use of a lateral thoracotomy approach. Thorax. 1986; 41(9): 692-695. doi: 10.1136/thx.41.9.692</mixed-citation><mixed-citation xml:lang="en">Walker WS, Sang CTM. Avoidance of patent anterior grafts at revisional coronary artery surgery: Use of a lateral thoracotomy approach. Thorax. 1986; 41(9): 692-695. doi: 10.1136/thx.41.9.692</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Doty JR, Salazar JD, Fonger JD, Walinsky PL, Sussman MS, Salomon NW. Reoperative MIDCAB grafting: 3-year clinical experience. Eur J Cardiothorac Surg. 1998; 13(6): 641-649. doi: 10.1016/s1010-7940(98)00086-4</mixed-citation><mixed-citation xml:lang="en">Doty JR, Salazar JD, Fonger JD, Walinsky PL, Sussman MS, Salomon NW. Reoperative MIDCAB grafting: 3-year clinical experience. Eur J Cardiothorac Surg. 1998; 13(6): 641-649. doi: 10.1016/s1010-7940(98)00086-4</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
