actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2021-6.4.7actabiomedica-2975Research ArticleИНФЕКЦИОННЫЕ БОЛЕЗНИINFECTIOUS DISEASESОбзор потенциальных препаратов для антивирусной и упреждающей противоспалительной терапии новой коронавирусной инфекции, вызванной вирусом SARS-CoV-2Overview of potential drugs for the treatment of new coronavirus Infection (COVID-19)https://orcid.org/0000-0002-7313-3432ШиробоковЯ. Е.ShirobokovYa. E.

 аспирант кафедры управления и экономики фармации

443099, г. Самара, ул. Чапаевская, 89, Россия 

 Postgraduate at the Department of Pharmacy Management and Economics

 Chapayevskaya str. 89, Samara 443099, Russian Federation 

yshirobokov@gmail.comГладуноваЕ. П.GladunovaE. P.

 доктор фармацевтических наук, доцент, профессор кафедры управления и экономики фармации

443099, г. Самара, ул. Чапаевская, 89, Россия 

 Dr. Sc. (Pharm.), Docent, Professor at the Department of Pharmacy Management and Economics

 Chapayevskaya str. 89, Samara 443099, Russian Federation 

epg87@mail.ruБородулинаЕ. А.BorodulinaE. A.

 доктор медицинских наук, профессор, заведующая кафедрой фтизиатрии и пульмонологии

443099, г. Самара, ул. Чапаевская, 89, Россия 

 Dr. Sc. (Med.), Professor, Head of the Department of Phthisiology and Pulmonology

 Chapayevskaya str. 89, Samara 443099, Russian Federation 

borodulinbe@yandex.ruСухановаА. Е.SukhanovaA. E.

  клинический ординатор кафедры фтизиатрии и пульмонологии

443099, г. Самара, ул. Чапаевская, 89, Россия 

 Resident at the Department of Phthisiology and Pulmonology 

 Chapayevskaya str. 89, Samara 443099, Russian Federation 

an.sukhanova2014@yandex.ruФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РоссииSamara State Medical University202112102021647486Copyright © Широбоков Я.Е., Гладунова Е.П., Бородулина Е.А., Суханова А.Е., 20212021Широбоков Я.Е., Гладунова Е.П., Бородулина Е.А., Суханова А.Е.Shirobokov Y.E., Gladunova E.P., Borodulina E.A., Sukhanova A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/2975

Новая коронавирусная инфекция (SARS-CoV-2), более известная как COVID-19, быстро переросла во всемирную пандемию, несущую значительное бремя для здравоохранения. Клинический спектр COVID-19 варьирует от бессимптомного носительства или лёгкого респираторного заболевания до развития тяжёлой внебольничной пневмонии. На данный момент не существует каких-либо утверждённых лекарственных препаратов или превентивных терапевтических стратегий для борьбы с инфекцией. Решения о назначении многих лекарственных препаратов принимаются на основе результатов, полученных в исследованиях in vitro, или мнений экспертов. Большинство препаратов, используемых в настоящее время, являются одобренными противовирусными средствами или антителами против других заболеваний. Тем не менее, в мире проводятся сотни клинических исследований, направленных на открытие эффективных методов лечения COVID-19. В данной статье обобщены результаты клинических исследований потенциальных терапевтических препаратов, используемых в качестве терапии COVID-19. Основываясь на данном обзоре, можно сделать вывод о том, что до сих пор нет высококачественных доказательств в поддержку любого из нижеописанных препаратов. Пока не будут получены однозначные результаты рандомизированных контролируемых исследований, использование любого из нижеописанного препарата не является клинически доказанным в качестве эффективного лечения COVID-19.

The new coronavirus infection (SARS-CoV-2), better known as COVID-19, quickly evolved into a worldwide pandemic with a significant public health burden. Currently, there are no approved drugs or preventive therapeutic strategies to combat infection. Decisions about prescribing many medications are made based on the results obtained in in vitro studies, or expert opinions. Most of the drugs currently used to treat COVID-19 are approved antivirals or antibodies against other diseases. However, there are hundreds of clinical studies underway around the world to discover effective treatments for COVID-19. This article summarizes the results of clinical studies of potential therapeutic drugs used as COVID-19 therapy. Based on this review, it can be concluded that there is still no high-quality evidence to support any of the drugs described below. Until the unambiguous results of randomized controlled trials are available, the use of any of the following drugs is not clinically proven as an effective treatment for COVID-19.

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The authors declare that there are no conflicts of interest present.