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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2021-6.3.16</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-2859</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФЕССИОНАЛЬНЫЕ ЗАБОЛЕВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OCCUPATIONAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Силикоартрит: вопросы ранней диагностики, профилактики</article-title><trans-title-group xml:lang="en"><trans-title>Silicoarthritis: issues of early diagnosis, prevention</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4685-3669</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кукс</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuks</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p> врач терапевт клиники </p><p> 665827, Иркутская обл., г. Ангарск, микрорайон 12а, д.3, Россия </p></bio><bio xml:lang="en"><p> general practitioner of the clinic </p><p>microdistrict 12a, 3, 665827, Irkutsk region, Angarsk, Russian Federation </p></bio><email xlink:type="simple">missis.kux.2012@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9072-2781</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катаманова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Katamanova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> главный врач клиники, д. м. н., доцент</p><p> 665827, Иркутская обл., г. Ангарск, микрорайон 12а, д.3, Россия</p></bio><bio xml:lang="en"><p> head doctor of the clinic, Doctor of Medical Sciences, assistant professor </p><p>microdistrict 12a, 3, 665827, Irkutsk region, Angarsk, Russian Federation </p></bio><email xlink:type="simple">katamanova_e_v@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8935-9308</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhonova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> заведующая КДО клиники </p><p> 665827, Иркутская обл., г. Ангарск, микрорайон 12а, д.3, Россия</p></bio><bio xml:lang="en"><p> head of the consultative and diagnostic department of the clinic </p><p>microdistrict 12a, 3, 665827, Irkutsk region, Angarsk, Russian Federation </p></bio><email xlink:type="simple">Tikhonovaiv69@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7097-5864</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павленко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlenko</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> заведующая терапевтическим отделением клиники </p><p> 665827, Иркутская обл., г. Ангарск, микрорайон 12а, д.3, Россия</p></bio><bio xml:lang="en"><p> head of the clinic’s therapy department </p><p>microdistrict 12a, 3, 665827, Irkutsk region, Angarsk, Russian Federation </p></bio><email xlink:type="simple">ale21277@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7334-5320</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панчукова</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Panchukova</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> заведующая отделением лучевой диагностики </p><p> 665827, Иркутская обл., г. Ангарск, микрорайон 12а, д.3, Россия</p></bio><bio xml:lang="en"><p> head of the Department of Radiation Diagnostics department of the clinic </p><p> microdistrict 12a, 3, 665827, Irkutsk region, Angarsk, Russian Federation </p></bio><email xlink:type="simple">ksenia973@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Восточно-Сибирский институт медико-экологических исследований»</institution></aff><aff xml:lang="en"><institution>East-Siberian Institute of Medical and Ecological Research</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>16</day><month>08</month><year>2021</year></pub-date><volume>6</volume><issue>3</issue><fpage>154</fpage><lpage>162</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кукс А.Н., Катаманова Е.В., Тихонова И.В., Павленко Н.А., Панчукова К.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Кукс А.Н., Катаманова Е.В., Тихонова И.В., Павленко Н.А., Панчукова К.В.</copyright-holder><copyright-holder xml:lang="en">Kuks A.N., Katamanova E.V., Tikhonova I.V., Pavlenko N.A., Panchukova K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/2859">https://www.actabiomedica.ru/jour/article/view/2859</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Тяжесть течения силикоза усугубляется при присоединении осложнений, одним из серьезных и редких осложнений силикоза является силикоартрит или синдром Каплана (СК), доля которого составляет 0,1–0,6% всех случаев силикоза. Силикоартрит существенно снижает качество жизни заболевших и приводит к стойкой утрате трудоспособности.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Установить наиболее значимые методы диагностики силикоартрита для раннего обнаружения заболевания и предотвращения развития осложнений.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В статье представлены клинические случаи силикоза и его редкого осложнения – СК. Основой диагностики данной патологии являются рентгенологические, иммунологические и функциональные методы.</p></sec><sec><title>Результаты</title><p>Результаты. У пациентов со стажем более 5 лет в условиях воздействия аэрозолей фиброгенного действия, содержащих кремний диоксид кристаллический, с превышением предельно допустимой концентрации от 2,3 до 4 раз на основании мультиспиральной компьютерной томографии легких, при проведении которой в верхних и нижних долях легких определялись множественные полиморфные очаги, диаметром от 2 до 10 мм, частью сливающиеся между собой в перибронховаскулярные муфты, а также перифокально участки снижения воздушности по типу матового стекла и утолщение аксиального интерстиция, был установлен диагноз позднего силикоза, узелковая форма 2 стадии, диагноз был подтвержден данными биопсии. В динамике через 5 лет присоединились артралгические жалобы. На основании иммунологического (повышение фактора некроза опухоли-альфа, интерлейкин-1 б), рентгенологического исследования (остеоартроз дистальных и проксимальных межфаланговых, лучезапястных, плюсне-фаланговых суставов) диагноз был уточнен, как силикоартрит: синдром Каплана. </p></sec><sec><title>Заключение</title><p>Заключение. Диагностика силикоза и его осложнений на доклиническом этапе у работников, контактирующих с кварцевой пылью более 5 лет должна включать в себя: МСКТ легких, определение ФНО-альфа, ИЛ-1b, ревматоидного фактора и исследование функции внешнего дыхания, которые должны проводиться в профпатологических центрах.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The severity of the course of silicosis is aggravated by the addition of complications; one of the serious and rare complication of silicosis is silicoarthritis or Kaplan’s syndrome (KS), which accounts for 0.1-0.6% of all cases of silicosis. Silicoarthritis significantly reduces the quality of the life of patients and leads to early and persistent disability.</p></sec><sec><title>Aim</title><p>Aim. To establish the most significant methods of diagnosing silicoarthritis for early detection of the disease and prevention of complications.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The article presents clinical cases of silicosis and its rare complication - SC. The basis for the diagnosis of this pathology is X-ray, immunological and functional methods.</p></sec><sec><title>Results</title><p>Results. In patients with more than 5 years of experience exposed to aerosols of fibrogenic action, crystalline silicon dioxide, with an excess of the MPC level from 2.3 to 4 times on the basis of MSCT of the lungs, during which multiple polymorphic foci with a diameter of 2 up to 10 mm, partly merging with each other into peribronchovascular couplings, as well as perifocal areas of reduced airiness like ground glass and thickening of the axial interstitium, a diagnosis of late silicosis, stage 2 nodular form was established, the diagnosis was confirmed by biopsy data. In dynamics, after 5 years, arthralgic complaints joined. On the basis of immunological (increased TNF-alpha, IL-1b), X-ray examination (osteoarthritis of the distal and proximal interphalangeal, wrist, metatarsophalangeal joints), the diagnosis was clarified as Silicoarthritis: Kaplan’s syndrome.</p></sec><sec><title>Conclusion</title><p>Conclusion. Diagnosis of silicosis and its complications at the preclinical stage in workers who have been in contact with silica dust for 5 years or more should include: MSCT of the lungs, determination of TNF-alpha, IL-1b, rheumatoid factor, and a study of respiratory function.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>силикоз</kwd><kwd>диагностика силикоартрита</kwd><kwd>синдром Каплана</kwd><kwd>фиброгенная пыль</kwd><kwd>профессиональные заболевания легких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>silicosis</kwd><kwd>diagnosis of silicoarthritis</kwd><kwd>Kaplan syndrome</kwd><kwd>fibrogenic dust</kwd><kwd>occupational lung diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Профессиональная патология: национальное руководство. Под ред. Измерова Н. Ф. 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