actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2021-6.3.6actabiomedica-2847Research ArticleИНФЕКЦИОННЫЕ БОЛЕЗНИINFECTIOUS DISEASESПерспективы использования синтетических селенорганических соединений для коррекции метаболического и иммунного статуса при вакцинальных процессах, вызванных живыми аттенуированными вакцинами против особо опасных инфекцийProspects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infectionshttps://orcid.org/0000-0001-7357-2219ЮрьеваО. В.YurievaO. V.

 кандидат биологических наук, старший научный сотрудник лаборатории патофизиологии 

тел.: 8 (3952) 22-01-35, факс: 8 (3952) 22-01-40

 664047, Иркутская область, г. Иркутск, ул. Трилиссера, 78, Россия 

 Cand. Sc. (Biol.), Senior Research Officer of Pathophysiological Laboratory

 Trilissera st, 78, 664047, Irkutsk region, Irkutsk, Russian Federation 

olga.yur1963@gmail.comhttps://orcid.org/0000-0001-8561-6207ДубровинаВ. И.DubrovinaV. I.

 доктор биологических наук, заведующая лабораторией патофизиологии 

тел.: 8 (3952) 22-01-35, факс: 8 (3952) 22-01-40

664047, Иркутская область, г. Иркутск, ул. Трилиссера, 78, Россия 

 Dr. Sc. (Biol.), Head of Pathophysiological Laboratory 

 Trilissera st, 78, 664047, Irkutsk region, Irkutsk, Russian Federation 

dubrovina-valya@mail.ruhttps://orcid.org/0000-0002-6381-4517ПятидесятниковаА. Б.PyatidesyatnikovaA. B.

 младший научный сотрудник

тел.: 8 (3952) 22-01-35, факс: 8 (3952) 22-01-40

664047, Иркутская область, г. Иркутск, ул. Трилиссера, 78, Россия 

 Junior Research Officer of Pathophysiological Laboratory  

 Trilissera st, 78, 664047, Irkutsk region, Irkutsk, Russian Federation 

adm@chumin.irkutsk.ruФКУЗ Иркутский научно-исследовательский противочумный институт РоспотребнадзораIrkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor202112082021636069Copyright © Юрьева О.В., Дубровина В.И., Пятидесятникова А.Б., 20212021Юрьева О.В., Дубровина В.И., Пятидесятникова А.Б.Yurieva O.V., Dubrovina V.I., Pyatidesyatnikova A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/2847

 В настоящей обзорной статье проведен анализ сведений, посвященных роли селена в регуляции метаболического и иммунного статуса макроорганизма. Рассмотрены данные  об эндогенных функциональных селенсодержащих  молекулах, к которым относятся селеноцистеин,  селенометионин, а также селенопротеины. Представлены  данные о патологиях, связанных с дефицитом этого микроэлемента, его иммунотропных свойствах и  адъювантных эффектах. Показана роль селенопротеинов в  регуляции окислительно-восстановительных процессов.  Проанализированы данные об иммунотропной активности соединений, содержащих селен и перспективах их использования в качестве адъювантов. Последний раздел посвящен анализу литературных данных о биологических свойствах синтетических соединений селена, обладающих активностью, имитирующей каталитическую активность  селенопротеинов. Проведенный в настоящей работе анализ сведений о функциональной активности селенопротеинов свидетельствует об их ключевой роли в регуляции  метаболических и иммунных процессов, а также в  поддержании гомеостаза. Представленные в обзоре сведения о биологической активности и механизмах действия новых  синтетических малотоксичных органических соединений селена могут послужить основой для разработки неспецифических  средств метаболической и иммунной коррекции вакцинальных процессов, вызванных как живыми аттенуированными  вакцинами, так и искусственно созданными. 

 This review article analyzes the data on the role of selenium in the regulation of the metabolic and immune status of a macroorganism. The data on endogenousfunctional selenium-containing molecules, which include selenocysteine, selenomethionine, and selenoproteins, are considered. The data on the pathologies associated with the deficiency of this microelement, its  immunotropic properties and adjuvant effects are presented. The role of selenoproteins in the regulation of redox processes has been shown. The data on the immunotropic activity of compounds containing selenium and the prospects for their use as adjuvants are analyzed. The last section is devoted to the analysis of literature data on the biological properties of synthetic selenium compounds with an activity that mimics the catalytic activity of selenoproteins. The analysis of the data on the functional activity of selenoproteins carried out in this work indicates their key role in the regulation of metabolic and immune processes, as well as in maintaining homeostasis. The information presented in this review on the biological activity and mechanisms of action of new synthetic low-toxic organic compounds of selenium can serve as a basis for the development of nonspecific means of metabolic and immune correction of vaccinal processes caused by both live attenuated vaccines and artificially created ones. 

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The authors declare that there are no conflicts of interest present.