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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2021-6.2.22</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-2751</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SURGERY</subject></subj-group></article-categories><title-group><article-title>Значение цистоскопии в оценке интерстициального цистита/синдрома болезненного мочевого пузыря</article-title><trans-title-group xml:lang="en"><trans-title>The Value of Cystoscopy in the Assessment of Interstitial Cystitis/Bladder Pain Syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1047-167X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шолан</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Sholan</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, заведующий отделением «Почечные болезни и трансплантология», </p><p>AZ1122, г. Баку, Тбилисский просп., 147</p></bio><bio xml:lang="en"><p>Cand. Sc. (Med.), Head of the Department of Renal Diseases and Transplantology,</p><p>Tbilisisskiy ave. 147, Baku AZ1122</p></bio><email xlink:type="simple">drrashad@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский лечебно-диагностический центр Министерства Здравоохранения Азербайджанской Республики</institution></aff><aff xml:lang="en"><institution>Republican Centre of Diagnosis and Treatment of Azerbaijan Health Ministry</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2021</year></pub-date><volume>6</volume><issue>2</issue><fpage>198</fpage><lpage>204</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шолан Р.Ф., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Шолан Р.Ф.</copyright-holder><copyright-holder xml:lang="en">Sholan R.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/2751">https://www.actabiomedica.ru/jour/article/view/2751</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. В диагностике интерстициального цистита/синдрома болезненного мочевого пузыря (ИЦ/СБМП) существуют значительные различия, в частности, имеются разногласия относительно диагностической роли цистоскопии или цистоскопии с гидродистензией.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: оценить результаты цистоскопии с гидродистензией у женщин с ИЦ/СБМП.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Обследовано 126 женщин с ИЦ/СБМП, средний возраст – 46,7 ± 14,0 года. Длительность заболевания составила 6,0 ± 2,8 года. Использованы опросники PUF, VAS, USS, калиевый тест. Выполнены цистоскопия и гидродистензия мочевого пузыря.</p></sec><sec><title>Результаты</title><p>Результаты. Сумма баллов по шкалам PUF составила 8,14 ± 1,76, по VAS – 5,45 ± 0,93, по USS – 2,63 ± 0,91. Положительный калиевый тест выявлялся в 91,3 % случаев, чувствительность теста составила 86,5 %, специфичность – 84,6 %. Анатомическая ёмкость мочевого пузыря составила 308,0 ± 77,5 мл. Средний показатель максимального наполнения мочевого пузыря у женщин с лёгкой болью был выше, чем при умеренной и сильной боли на 30,9 % (р &lt; 0,05) и 53,0 % (р &lt; 0,01) соответственно. В 11,9 % случаев выявлены полипы у наружного отверстия уретры. При цистоскопии в 39,8 % случаев определялись диффузная кровоточивость слизистой, в 21,4 % случаев – диффузные подслизистые кровотечения, в 14,3 % случаев – редкие гломеруляции, в 12,7 % случаев – поражения Гуннера. После гидродистензии изменения чаще носили диффузный характер (n = 57). Выявлена значимая связь (r = –0,57, p &lt; 0,01) между максимальным наполнением мочевого пузыря и степенью выраженности отклонений слизистой оболочки. Степень выраженности изменений слизистой оболочки мочевого пузыря положительно коррелировала с суммой баллов по анкете PUF (r = +0,61, р = 0,003), по анкете VAS (r = +0,59, p = 0,008) и по анкете USS (r = +0,66, р = 0,005).</p></sec><sec><title>Заключение</title><p>Заключение. Цистоскопия может использоваться для исследования ИЦ/СБМП в соответствии с рекомендациями международных обществ. Полученные данные могут способствовать повышению эффективности диагностики ИЦ/СБМП. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. There are significant differences in the diagnosis of interstitial cystitis/painful bladder syndrome (IC/ BPS), in particular, controversy regarding the diagnostic role of cystoscopy or hydrodistension cystoscopy.</p><p>The aim of the study was to evaluate the results of cystoscopy with hydrodistension in women with IC/BPS.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study involved 126 women with IC/BPS, mean age – 46.7 ± 14.0 years. The duration of the disease was 6.0 ± 2.8 years. Questionnaires PUF, VAS, USS, and potassium test were used. Cystoscopy and urinary bladder hydrodistension were performed.</p></sec><sec><title>Results</title><p>Results. The sum of points on the PUF scale was 8.14 ± 1.76, on the VAS scale – 5.45 ± 0.93, on the USS scale – 2.63 ± 0.91. A positive potassium test was detected in 91.3 % of cases, the sensitivity of the test was 86.5 %, the specificity – 84.6 %. The anatomical bladder capacity was 308.0 ± 77.5 ml. The average indicator of maximum bladder filling in women with mild pain was higher than in moderate and severe pain by 30.9 % (p &lt; 0.05) and 53.0 % (p &lt; 0.01), respectively. In 11.9 % of cases, polyps were detected at the external opening of the urethra. During cystoscopy, diffuse mucosal bleeding was detected in 39.8 % of cases, diffuse submucosal bleeding – in 21.4 %, rare glomerulations – in 14.3 %, Gunner’s lesions in 12.7 % of cases. After hydrodistension, the changes were more often diffuse (n = 57). There was a significant relationship (r = –0.57, p &lt; 0.01) between the maximum filling of the bladder and the degree of severity of mucosal abnormalities. The severity of changes in the mucous membrane of the bladder positively correlated with the sum of points on the PUF questionnaire (r = +0.61, p = 0.003), on the VAS questionnaire (r = +0.59, p = 0.008) and according to the USS questionnaire (r = +0.66, p = 0.005).</p></sec><sec><title>Conclusion</title><p>Conclusion. Cystoscopy can be used to examine IC/BPS in accordance with the recommendations of international societies. The obtained data can help to improve the effectiveness of IC/PBS diagnostics. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>интерстициальный цистит/синдром болезненного мочевого пузыря</kwd><kwd>женщины</kwd><kwd>калиевый тест</kwd><kwd>цистоскопия</kwd><kwd>гидродистензия</kwd><kwd>диффузная кровоточивость слизистой</kwd><kwd>диффузные подслизистые кровотечения</kwd><kwd>гломеруляции</kwd><kwd>поражения Гуннера</kwd></kwd-group><kwd-group xml:lang="en"><kwd>interstitial cystitis/bladder pain syndrome</kwd><kwd>women</kwd><kwd>potassium test</kwd><kwd>cystoscopy</kwd><kwd>hydrodistension</kwd><kwd>diffuse mucosal bleeding</kwd><kwd>diffuse submucosal bleeding</kwd><kwd>glomerulations</kwd><kwd>Hunner’s lesions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А.В., Шаров М.Н., Арефьева О.А., Пушкарь Д.Ю. Синдром болезненного мочевого пузыря/интерстициальный цистит: факторы прогноза клинического течения заболевания. Вестник урологии. 2018; 6(3): 26-35. doi: 10.21886/2308-6424-2017-6-3-26-35</mixed-citation><mixed-citation xml:lang="en">Zajcev AV, Sharov MN, Aref’eva OA, Pushkar DJu. Painful bladder syndrome/interstitial cystitis: predictors of  the  clinical course of the disease. Vestnik Urologii. 2018; 6(3): 26-35. (In Russ.). doi: 10.21886/2308-6424-2017-6-3-26-35</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pape J, Falconi G, De Mattos Lourenco TR, Doumouchtsis SK, Betschart C. Variations in bladder pain syndrome/interstitial cystitis (IC) definitions, pathogenesis, diagnostics and treatment: A systematic review and evaluation of national and international guidelines. Int UrogynecolJ. 2019; 30(11): 1795-1805. doi: 10.1007/s00192-019-03970-5</mixed-citation><mixed-citation xml:lang="en">Pape J, Falconi G, De Mattos Lourenco TR, Doumouchtsis SK, Betschart C. Variations in bladder pain syndrome/interstitial cystitis (IC) definitions, pathogenesis, diagnostics and treatment: A systematic review and evaluation of national and international guidelines. Int UrogynecolJ. 2019; 30(11): 1795-1805. doi: 10.1007/s00192-019-03970-5</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hurst RE. Structure, function, and pathology of proteoglycans and glycosaminoglycans in the urinary tract. World J Urol. 1994; 12(1): 3-10. doi: 10.1007/BF00182044</mixed-citation><mixed-citation xml:lang="en">Hurst  RE. Structure, function, and pathology of  proteoglycans and glycosaminoglycans in the urinary tract. World J Urol. 1994; 12(1): 3-10. doi: 10.1007/BF00182044</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Syed LJ, Ilchak DL. Bladder pain syndrome in females. J Nurse Pract. 2017; 13(4): 291-295. doi: 10.1016/j.nurpra.2016.11.025</mixed-citation><mixed-citation xml:lang="en">Syed  LJ, Ilchak  DL. Bladder pain syndrome in  females. J  Nurse Pract. 2017; 13(4): 291-295. doi:  10.1016/j.nurpra.2016.11.025</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/ interstitial cystitis: An ESSIC proposal. Eur Urol. 2008; 53(1): 60-67. doi: 10.1016/j.eururo.2007.09.019</mixed-citation><mixed-citation xml:lang="en">Van  de  Merwe  JP, Nordling  J, Bouchelouche  P, Bouchelouche  K, Cervigni  M, Daha  LK, et  al. Diagnostic criteria, classification, and nomenclature for  painful bladder syndrome/ interstitial cystitis: An ESSIC proposal. Eur Urol. 2008; 53(1): 60-67. doi: 10.1016/j.eururo.2007.09.019</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hanno PM, Erickson D, Moldwin R, Faraday MM. American Urological Association. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment. JUrol. 2015; 193(5): 1545-1553. doi: 10.1016/j.juro.2015.01.086</mixed-citation><mixed-citation xml:lang="en">Hanno PM, Erickson D, Moldwin R, Faraday MM. American Urological Association. Diagnosis and treatment of  interstitial cystitis/bladder pain syndrome: AUA guideline amendment. JUrol. 2015; 193(5): 1545-1553. doi: 10.1016/j.juro.2015.01.086</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Tailor VK, Morris E, Bhide AA, Fernando R, Digesu GA, Khullar V. Does cystoscopy method affect the investigation of bladder pain syndrome/interstitial cystitis? Int Urogynecol J. 2020; 1-7. doi: 10.1007/s00192-020-04512-0</mixed-citation><mixed-citation xml:lang="en">Tailor VK, Morris E, Bhide AA, Fernando R, Digesu GA, Khullar V. Does cystoscopy method affect the investigation of bladder pain syndrome/interstitial cystitis? Int Urogynecol J. 2020; 1-7. doi: 10.1007/s00192-020-04512-0</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Logadottir Y, Fall M, Kabjorn-Gustafsson C, Peeker R. Clinical characteristics differ considerably between phenotypes of bladder pain syndrome/interstitial cystitis. Scand J Urol Nephrol. 2012; 46(5): 365-370. doi: 10.3109/00365599.2012.689008</mixed-citation><mixed-citation xml:lang="en">Logadottir Y, Fall M, Kabjorn-Gustafsson C, Peeker R. Clinical characteristics differ considerably between phenotypes of bladder pain syndrome/interstitial cystitis. Scand J Urol Nephrol. 2012; 46(5): 365-370. doi: 10.3109/00365599.2012.689008</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Whitmore KE, Fall M, Sengiku A, Tomoe H, Logadottir Y, Kim Y.H. Hunner lesion versus non-Hunner lesion interstitial cystitis/bladder pain syndrome. Int J Urol. 2019; 1: 26-34. doi: 10.1111/iju.13971</mixed-citation><mixed-citation xml:lang="en">Whitmore KE, Fall M, Sengiku A, Tomoe H, Logadottir Y, Kim Y.H. Hunner lesion versus non-Hunner lesion interstitial cystitis/bladder pain syndrome. Int J Urol. 2019; 1: 26-34. doi: 10.1111/iju.13971</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ens G, Garrido GL. Role of cystoscopy and hydrodistention in the diagnosis of interstitial cystitis/bladder pain syndrome. Transl Androl Urol. 2015; 4(6): 624-628. doi: 10.3978/j.issn.2223- 4683.2015.09.04</mixed-citation><mixed-citation xml:lang="en">Ens G, Garrido GL. Role of cystoscopy and hydrodistention in  the  diagnosis of  interstitial cystitis/bladder pain syndrome. Transl Androl Urol. 2015; 4(6): 624-628. doi:  10.3978/j.issn.2223-4683.2015.09.04</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gillenwater JY, Wein AJ. Summary of the National Institute of Arthritis, Diabetes and Kidney Diseases. Workshop on interstitial cystitis. National Institutes of Health, Bethesda, Maryland, August 28-29, 1987. J Urol. 1988; 140(1): 203-206. doi: 10.1016/S0022-5347(17)41529-1</mixed-citation><mixed-citation xml:lang="en">Gillenwater JY, Wein AJ. Summary of the National Institute of Arthritis, Diabetes and Kidney Diseases. Workshop on interstitial cystitis. National Institutes of Health, Bethesda, Maryland, August 28-29, 1987. J Urol. 1988; 140(1): 203-206. doi: 10.1016/S0022- 5347(17)41529-1</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Parsons CL, Greenberger M, Gabal L, Bidair M, Barme G. The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis. J Urol. 1998; 159: 1862-1866.</mixed-citation><mixed-citation xml:lang="en">Parsons CL, Greenberger M, Gabal L, Bidair M, Barme G. The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis. J Urol. 1998; 159: 1862-1866.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Chung SD, Liao CH, Chen YC, Kuo HC. Urgency severity scale could predict urodynamic detrusor overactivity in patients with overactive bladder syndrome. Neurourol Urodyn. 2011; 30(7): 1300-1304. doi: 10.1002/nau.21057</mixed-citation><mixed-citation xml:lang="en">Chung SD, Liao CH, Chen YC, Kuo HC. Urgency severity scale could predict urodynamic detrusor overactivity in patients with overactive bladder syndrome. Neurourol Urodyn. 2011; 30(7): 1300-1304. doi: 10.1002/nau.21057</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rigaud J, Delavierre D, Sibert L, Labat JJ. Hydrodistension in the therapeutic management of painful bladder syndrome. Prog Urol. 2010; 20(12): 1054-1059. doi: 10.1016/j.purol.2010.08.049</mixed-citation><mixed-citation xml:lang="en">Rigaud J, Delavierre D, Sibert L, Labat JJ. Hydrodistension in the therapeutic management of painful bladder syndrome. Prog Urol. 2010; 20(12): 1054-1059. doi: 10.1016/j.purol.2010.08.049</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects. JAMA. 2013; 310(20): 2191-2194. doi: 10.1001/jama.2013.281053</mixed-citation><mixed-citation xml:lang="en">World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects. JAMA. 2013; 310(20): 2191-2194. doi: 10.1001/jama.2013.281053</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cox A, Golda N, Nadeau G, Nickel JC, Carr L, Corcos J, et al. CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome. Can Urol Assoc J. 2016; 10(5-6): E136-E155. doi: 10.5489/cuaj.3786</mixed-citation><mixed-citation xml:lang="en">Cox A, Golda N, Nadeau G, Nickel JC, Carr L, Corcos J, et al. CUA guideline: Diagnosis and treatment of  interstitial cystitis/ bladder pain syndrome. Can Urol Assoc J. 2016; 10(5-6): E136-E155. doi: 10.5489/cuaj.3786</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang Y-H, Jhang J-F, Kuo H-C. Revisiting the role of potassium sensitivity testing and cystoscopic hydrodistention for the diagnosis of interstitial cystitis. PLoS ONE. 2016; 11(3): e0151692. doi: 10.1371/journal.pone.0151692</mixed-citation><mixed-citation xml:lang="en">Jiang Y-H, Jhang J-F, Kuo H-C. Revisiting the role of potassium sensitivity testing and cystoscopic hydrodistention for the diagnosis of  interstitial cystitis. PLoS ONE. 2016; 11(3): e0151692. doi: 10.1371/journal.pone.0151692</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Аль-Шукри С.Х., Кузьмин И.В., Слесаревская М.Н., Игнашов Ю.А. Гидродистензия мочевого пузыря в лечении больных интерстициальным циститом/синдромом болезненного мочевого пузыря. Урология. 2018; 1: 26-29. doi: 10.18565/urology.2018.1.26-29</mixed-citation><mixed-citation xml:lang="en">Al-Shukri SH, Kuzmin IV, Slesarevskaya MN, Ignashov YuA. Hydrodistension of  the  bladder in  the  treatment of  patients with interstitial cystitis/painful bladder syndrome. Urologiia. 2018; 1: 26-29. (In Russ.). doi: 10.18565/urology.2018.1.26-29</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Аль-Шукри С.Х., Кузьмин И.В., Слесаревская М.Н., Игнашов Ю.А. Применение русскоязычной версии шкалы симптомов тазовой боли, ургентности и частоты мочеиспускания (PUF Scale) у больных с синдромом болезненного мочевого пузыря. Урологические ведомости. 2017; 7(2): 5-9. doi: 10.17816/uroved725-9</mixed-citation><mixed-citation xml:lang="en">Al-Shukri SK, Kuzmin IV, Slesarevskaya MN, Ignashov YA. Use of the Russian version of pelvic pain and urgency/frequency patient symptom scale (PUF scale) in patients with the bladder pain syndrome. Urology reports (St.-Petersburg). 2017; 7(2): 5-9. (In Russ.). doi: 10.17816/uroved725-9</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Аль-Шукри С.Х., Кузьмин И.В., Слесаревская М.Н., Игнашов Ю.А. Симптоматика и цистоскопическая картина у женщин с синдромом болезненного мочевого пузыря. Учёные записки СПбГМУ им. акад. И.П. Павлова. 2017; 24(4): 50-54. doi: 10.24884/1607-4181-2017-24-4-50-54</mixed-citation><mixed-citation xml:lang="en">Al-Shukri SH, Kuzmin IV, Slesarevskaya MN, Ignashov YuA. Symptomatics and cystoscopic results in women with the pain bladder syndrome. Record of  the  I.P.  Pavlov St.  Petersburg State Medical University. 2017; 24(4): 50-54. (In Russ.). doi: 10.24884/1607-4181-2017-24-4-50-54</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Parsons CL. The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/ overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. BJU Int. 2011; 107(3): 370-375. doi: 10.1111/j.1464-410X.2010.09843.x</mixed-citation><mixed-citation xml:lang="en">Parsons CL. The role of a leaky epithelium and potassium in  the  generation of  bladder symptoms in  interstitial cystitis/ overactive bladder, urethral syndrome, prostatitis and  gynaecological chronic pelvic pain. BJU Int. 2011; 107(3): 370-375. doi: 10.1111/j.1464-410X.2010.09843.x</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gülpınar Ö, Esen B, Akpınar Ç, Baklacı U, Gökce Mİ, Süer E, et al. Potassium sensitivity test predicts hydrodistention efficacy in patients with bladder pain syndrome/interstitial cystitis. Turk J Urol. 2020; 46(3): 231-235. doi: 10.5152/tud.2019.19084</mixed-citation><mixed-citation xml:lang="en">Gülpınar  Ö, Esen  B, Akpınar  Ç, Baklacı  U, Gökce  Mİ, Süer  E, et  al. Potassium sensitivity test predicts hydrodistention efficacy in  patients with bladder pain syndrome/interstitial cystitis. Turk J Urol. 2020; 46(3): 231-235. doi: 10.5152/tud.2019.19084</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Пушкарь Д.Ю., Зайцев А.В., Гундорова Л.В., Ковылина М.В. Ретроспективный анализ морфологических исследований у больных интерстициальным циститом. Урология. 2005; 4: 53-56.</mixed-citation><mixed-citation xml:lang="en">Pushkar  DYu, Zaitsev  AV, Gundorova  LV, Kovylina  MV. Retrospective analysis of morphological studies in patients with interstitial cystitis. Urologiia. 2005; 4: 53-56. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Grossklaus DJ, Franke JJ. Vesical necrosis after hydrodistension of the urinary bladder in a patient with interstitial cystitis. BJU Int. 2000; 86: 140-141. doi: 10.1046/j.1464-410x.2000.01739.x</mixed-citation><mixed-citation xml:lang="en">Grossklaus  DJ, Franke  JJ. Vesical necrosis after hydrodistension of  the  urinary bladder in  a  patient with  interstitial cystitis. BJU Int. 2000; 86: 140-141. doi: 10.1046/j.1464-410x.2000.01739.x</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
