<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.12737/23340</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-268</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Предикторы формирования гипертен-зивного ответа на физическую нагрузку у подростков с ожирением</article-title><trans-title-group xml:lang="en"><trans-title>Predictors of exaggerated blood pressure response to aerobic exercise in obese adolescents</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данилюк</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilyuk</surname><given-names>L. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Погодина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pogodina</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рычкова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rychkova</surname><given-names>L. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Машанская</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mashanskaya</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»</institution></aff><aff xml:lang="en"><institution>Scientific Centre for Family Health and Human Reproduction Problems</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2016</year></pub-date><volume>1</volume><issue>5</issue><fpage>9</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Данилюк Л.В., Погодина А.В., Рычкова Л.В., Машанская А.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Данилюк Л.В., Погодина А.В., Рычкова Л.В., Машанская А.В.</copyright-holder><copyright-holder xml:lang="en">Danilyuk L.V., Pogodina A.V., Rychkova L.V., Mashanskaya A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/268">https://www.actabiomedica.ru/jour/article/view/268</self-uri><abstract><p>Максимальный тредмил-тест по протоколу Брюса проведён у подростков с избыточным весом и исходно нормальнымуровнем артериального давления. Обнаружено, что формирование гипертензивного паттерна реагирования на физическую нагрузку у подростков с ожирением, не страдающих артериальной гипертензией, более свойственно для старших подростков, имеющих донагрузочныеуровни систолического артериального давления выше нормальных значений. Нарушение липидного, углеводного обмена, а также степень избытка веса не оказали влияния на формирование данного типа реагирования на физическую нагрузку в этой когорте больных.</p></abstract><trans-abstract xml:lang="en"><p>Association of blood pressure response during exercise of cardiometabolic risk factors (CMRF) is demonstrated in adults. The objective was to determine predictors of raised exercise blood pressure (BP) response during aerobic exercise in obese adolescents. The maximal treadmill test using the Bruce protocol was performed in 82 normotensive obese adolescents (12-17 y.o., 43 boys). Adolescents were divided into 2 groups: group 1 (n = 68) - children with normal BP response to exercise; group 2 (n = 14) - adolescents who had excessive increase in systolic BP (SBP) during exercise. We used logistic regression analysis to examine the associations between cardiometabolic risk factors (CMRF) and SBP response during exercise with adjustment for baseline SBP, sex, age and duration of exercise test period. We have found exaggerated BP response to exercise in 17.1 % of patients. In adolescents of group 2 baseline SBP was higher than in group 1 (p = 0.01). Glucose level and lipid metabolism disturbances, SDS Z-score, baseline SBP levels only by 24.8 % explained the formation of the hyperreactive SBP response to exercise (χ2 = 13.2; р = 0.068). Only baseline SBP was an independent predictor for exaggerated BP response (p = 0.025) and age was a significant trend towards influence (p = 0.054). Exaggerated BP response to exercise in normotensive obese adolescents is more common for older adolescents who have baseline SBP levels in the range of elevated normal values. Knowing CMRF as well as the degree of excess weight has no effect on excessive BP rise during exercise.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиометаболический риск</kwd><kwd>тредмил</kwd><kwd>ожирение</kwd><kwd>избыточный вес</kwd><kwd>подростки</kwd><kwd>проба с физической нагрузкой</kwd><kwd>артериальное давление</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiometabolic risk</kwd><kwd>treadmill</kwd><kwd>obesity</kwd><kwd>adolescents</kwd><kwd>exercise tolerance test</kwd><kwd>blood pressure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Погодина А.В., Долгих В.В., Рычкова Л.В. Мочевая кислота и факторы кардиометаболического риска при артериальной гипертензии у подростков // Кардиология. - 2014. - Т. 54, № 7. - С. 36-42</mixed-citation><mixed-citation xml:lang="en">Погодина А.В., Долгих В.В., Рычкова Л.В. Мочевая кислота и факторы кардиометаболического риска при артериальной гипертензии у подростков // Кардиология. - 2014. - Т. 54, № 7. - С. 36-42</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Погодина А.В., Машанская А.В., Данилюк Л.В., Рычкова Л.В., Мандзяк Т.В., Кравцова О.В. Гемоди-намический ответ на субмаксимальную нагрузку у подростков с избыточной массой тела и ожирением // Вопросы практической педиатрии. - 2016. - № 6. -С. 20-25</mixed-citation><mixed-citation xml:lang="en">Погодина А.В., Машанская А.В., Данилюк Л.В., Рычкова Л.В., Мандзяк Т.В., Кравцова О.В. Гемоди-намический ответ на субмаксимальную нагрузку у подростков с избыточной массой тела и ожирением // Вопросы практической педиатрии. - 2016. - № 6. -С. 20-25</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Тутельян В.Л., Батурин А.К., Конь И.Я., Мартинчик А.Н., Углицких А.К., Коростелева М.М., Тоболева М.А., Алешина И.В. Распространенность ожирения и избыточной массы тела среди детского населения РФ: мультицентровое исследование // Педиатрия. -2014. - № 5. - С. 28-31</mixed-citation><mixed-citation xml:lang="en">Тутельян В.Л., Батурин А.К., Конь И.Я., Мартинчик А.Н., Углицких А.К., Коростелева М.М., Тоболева М.А., Алешина И.В. Распространенность ожирения и избыточной массы тела среди детского населения РФ: мультицентровое исследование // Педиатрия. -2014. - № 5. - С. 28-31</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Физическая активность. - Режим доступа: www.who.int/dietphysicalactivity/pa/ru</mixed-citation><mixed-citation xml:lang="en">Физическая активность. - Режим доступа: www.who.int/dietphysicalactivity/pa/ru</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Berger A., Grossman E., Katz M., Kivity S., Klempfner R., Segev S., Goldenberg I., Sidi Y., Maor E. (2015). Exercise blood pressure and the risk for future hypertension among normotensive middle-aged adults. J. Am. Heart Assoc., 4 (4), e001710. doi: 10,1161/JAHA.114.001710.</mixed-citation><mixed-citation xml:lang="en">Berger A., Grossman E., Katz M., Kivity S., Klempfner R., Segev S., Goldenberg I., Sidi Y., Maor E. (2015). Exercise blood pressure and the risk for future hypertension among normotensive middle-aged adults. J. Am. Heart Assoc., 4 (4), e001710. doi: 10,1161/JAHA.114.001710.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Double burden of malnutrition. Available at: http://www.who.int/entity/nutrition/double-burden-malnutrition/en.</mixed-citation><mixed-citation xml:lang="en">Double burden of malnutrition. Available at: http://www.who.int/entity/nutrition/double-burden-malnutrition/en.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Emdin M., Gastaldelli A., Muscelli E., Macerata A., Natali A., Camastra S., Ferrannini E. (2001). Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss. Circulation; 103 (4), 513-519.</mixed-citation><mixed-citation xml:lang="en">Emdin M., Gastaldelli A., Muscelli E., Macerata A., Natali A., Camastra S., Ferrannini E. (2001). Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss. Circulation; 103 (4), 513-519.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Gaudreault V., Després J.P., Rhéaume C., Alméras N., Bergeron J., Tremblay A., Poirier P. (2013). Exercise-induced hypertension in men with metabolic syndrome: anthropometric, metabolic, and hemodynamic features. Metab. Syndr. Relat. Disord., 11 (1), 7-14.</mixed-citation><mixed-citation xml:lang="en">Gaudreault V., Després J.P., Rhéaume C., Alméras N., Bergeron J., Tremblay A., Poirier P. (2013). Exercise-induced hypertension in men with metabolic syndrome: anthropometric, metabolic, and hemodynamic features. Metab. Syndr. Relat. Disord., 11 (1), 7-14.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kavey R.E., Kveselis D.A., Gaum W.E. (1997). Exaggerated blood pressure response to exercise in children with increased low-density lipoprotein cholesterol. Am. Heart J., (13), 162-168.</mixed-citation><mixed-citation xml:lang="en">Kavey R.E., Kveselis D.A., Gaum W.E. (1997). Exaggerated blood pressure response to exercise in children with increased low-density lipoprotein cholesterol. Am. Heart J., (13), 162-168.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kohl H.W. 3rd, Nichaman M.Z., Frankowski R.F., Blair S.N. (1996). Maximal exercise hemodynamics and risk of mortality in apparently healthy men and women. Med. Sci. Sports Exerc., (28), 601-609.</mixed-citation><mixed-citation xml:lang="en">Kohl H.W. 3rd, Nichaman M.Z., Frankowski R.F., Blair S.N. (1996). Maximal exercise hemodynamics and risk of mortality in apparently healthy men and women. Med. Sci. Sports Exerc., (28), 601-609.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kurl S., Laukkanen J.A., Rauramaa R., Lakka T.A., Sivenius J, Salonen JT (2001). Systolic blood pressure response to exercise stress test and risk of stroke. Stroke, (32), 2036-2041.</mixed-citation><mixed-citation xml:lang="en">Kurl S., Laukkanen J.A., Rauramaa R., Lakka T.A., Sivenius J, Salonen JT (2001). Systolic blood pressure response to exercise stress test and risk of stroke. Stroke, (32), 2036-2041.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lambiasea M.J., Dornb J., Thurstona R.C., Roemmich JN (2014). Flow-mediated dilation and exercise blood pressure in healthy adolescents. J. Sci. Med. Sport, (17), 425-429.</mixed-citation><mixed-citation xml:lang="en">Lambiasea M.J., Dornb J., Thurstona R.C., Roemmich JN (2014). Flow-mediated dilation and exercise blood pressure in healthy adolescents. J. Sci. Med. Sport, (17), 425-429.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">M0ller N.C., Grөntved A., Wedderkopp N., Ried-Larsen M., Kristensen P.L., Andersen L.B., Froberg K et al. (2010). Cardiovascular disease risk factors and blood pressure response during exercise in healthy children and adolescents: The European Youth Heart Study. J. Appl. Physiol., (109), 1125-1132.</mixed-citation><mixed-citation xml:lang="en">M0ller N.C., Grөntved A., Wedderkopp N., Ried-Larsen M., Kristensen P.L., Andersen L.B., Froberg K et al. (2010). Cardiovascular disease risk factors and blood pressure response during exercise in healthy children and adolescents: The European Youth Heart Study. J. Appl. Physiol., (109), 1125-1132.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nakashima M., Miura K., Kido T., Saeki K., Tamura N., Matsui S., Morikawa Y., Nishijo M., Nakanishi Y., Nakagawa H. (2004). Exercise blood pressure in young adults as a predictor of future blood pressure: a 12-year follow-up of medical school graduates. J. Hum. Hypertens., 18 (11), 815-821.</mixed-citation><mixed-citation xml:lang="en">Nakashima M., Miura K., Kido T., Saeki K., Tamura N., Matsui S., Morikawa Y., Nishijo M., Nakanishi Y., Nakagawa H. (2004). Exercise blood pressure in young adults as a predictor of future blood pressure: a 12-year follow-up of medical school graduates. J. Hum. Hypertens., 18 (11), 815-821.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ribeiro M.M., Silva A.G., Santos N.S., Guazzelle I., Matos L.N.J., Trombetta I.C., Halpern A., Negrâo C.E., Villares S.M. (2005). Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation, (111), 1915-1923.</mixed-citation><mixed-citation xml:lang="en">Ribeiro M.M., Silva A.G., Santos N.S., Guazzelle I., Matos L.N.J., Trombetta I.C., Halpern A., Negrâo C.E., Villares S.M. (2005). Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation, (111), 1915-1923.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Singh J.P., Larson M.G., Manolio T.A., O’Donnell C.J., Lauer M., Evans J.C., Levy D. (1999). Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham Heart Study. Circulation, 99 (14), 1831-1836.</mixed-citation><mixed-citation xml:lang="en">Singh J.P., Larson M.G., Manolio T.A., O’Donnell C.J., Lauer M., Evans J.C., Levy D. (1999). Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham Heart Study. Circulation, 99 (14), 1831-1836.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wanne O.P., Haapoja E. (1988). Blood pressure during exercise in healthy children. Eur. J. Appl. Physiol. Occup. Physiol., 58 (1-2), 62-67.</mixed-citation><mixed-citation xml:lang="en">Wanne O.P., Haapoja E. (1988). Blood pressure during exercise in healthy children. Eur. J. Appl. Physiol. Occup. Physiol., 58 (1-2), 62-67.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
