actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.12737/23031actabiomedica-266Research ArticleЛЕКЦИИLECTURESГистологическая и иммуногистохимическая характеристика менингиом головного мозгаHistological and immunohistochemical characteristics of brain meningiomasБывальцевВ. А.ByvaltsevV. A.byval75vadim@yandex.ruСороковиковВ. А.SorokovikovV. A.noemail@neicon.ruСтепановИ. А.StepanovI. A.noemail@neicon.ruАнтипинаС. Л.AntipinaS. L.noemail@neicon.ruФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России;ФГБНУ «Иркутский научный центр хирургии и травматологии»; НУЗ «Дорожная клиническая больница на ст. Иркутск-Пассажирский ОАО «РЖД»; ГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования» Минздрава РоссииIrkutsk State Medical University;Irkutsk Scientific Center of Surgery and Traumatology;Railway Clinical Hospital at the Irkutsk-Passazhirskiy Railway Station of Russian Railways Ltd.; Irkutsk State Medical Academy of Continuing EducationФГБНУ «Иркутский научный центр хирургии и травматологии»;ГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования» Минздрава РоссииIrkutsk Scientific Center of Surgery and Traumatology;Irkutsk State Medical Academy of Continuing EducationФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РоссииIrkutsk State Medical UniversityНУЗ «Дорожная клиническая больница на ст. Иркутск-Пассажирский ОАО «РЖД»Railway Clinical Hospital at the Irkutsk-Passazhirskiy Railway Station of Russian Railways Ltd20162807201614187194Copyright © Бывальцев В.А., Сороковиков В.А., Степанов И.А., Антипина С.Л., 20162016Бывальцев В.А., Сороковиков В.А., Степанов И.А., Антипина С.Л.Byvaltsev V.A., Sorokovikov V.A., Stepanov I.A., Antipina S.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/266

Для менингиом, группы опухолей, происходящих из мозговых оболочек, присущ большой спектр морфологических характеристик, определяющих тип и степень злокачественности. Исследование анапластических менингиом представляет сложность, так как они имеют сходство с мягкотканными злокачественными новообразованиями. Иммуноокрашивание позволяет не только определить цитогенетический источник и степень злокачественности опухоли, но и обнаружить патологические белки - продукты транскрипции повреждённых участков ДНК и дать рекомендации по назначению таргетной терапии.

Meningiomas are among the most common primary intracranial tumors. They arise from meningothelial cells of the arachnoid layer that forms the external lining of the brain and occur primarily at the base of the skull in the parasellar regions as well as over the cerebral convexities. Of particular difficulty are anaplastic meningiomas, having similarities with malignant soft tissue tumors. Immunostaining allows to define not only the source of cytogenetic, tumor grade, but detect abnormal proteins - transcription products damaged DNA regions and make recommendations for the appointment of targeted therapy. Targeted effect on the meningioma will allow to achieve a significant increase in patient survival.

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The authors declare that there are no conflicts of interest present.