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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2020-5.6.8</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-2497</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИСКУССИОННЫЕ СТАТЬИ, ЛЕКЦИИ, НОВЫЕ ТРЕНДЫ МЕДИЦИНСКОЙ НАУКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISCUSSION PAPERS, LECTURES, NEW TRENDS IN MEDICAL SCIENCE</subject></subj-group></article-categories><title-group><article-title>Клеточные технологии в травматологии: от клетки до тканевой инженерии</article-title><trans-title-group xml:lang="en"><trans-title>Cellular Technologies in Traumatology: from Cells to Tissue Engineering</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2540-4525</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дремина</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dremina</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник лаборатории клеточных технологий и регенеративной медицины</p><p>664003, г. Иркутск, ул. Борцов Революции, 1, Россия </p></bio><bio xml:lang="en"><p>Cand. Sc. (Biol.), Senior Research Officer at the Laboratory of Cell Technologies and Regenerative Medicine</p><p>Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">drema76@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0270-404X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трухан</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Trukhan</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">predel4@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3980-050X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шурыгина</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shurygina</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">irinashurygina@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Иркутский научный центр хирургии и травматологии»</institution></aff><aff xml:lang="en"><institution>Irkutsk Scientific Centre of Surgery and Traumatology</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>01</month><year>2021</year></pub-date><volume>5</volume><issue>6</issue><fpage>66</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дремина Н.Н., Трухан И.С., Шурыгина И.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Дремина Н.Н., Трухан И.С., Шурыгина И.А.</copyright-holder><copyright-holder xml:lang="en">Dremina N.N., Trukhan I.S., Shurygina I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/2497">https://www.actabiomedica.ru/jour/article/view/2497</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>клеточные технологии</kwd><kwd>мезенхимальные стволовые клетки</kwd><kwd>репарация</kwd><kwd>травматология</kwd><kwd>кость</kwd><kwd>хрящ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>сell technologies</kwd><kwd>mesenchymal stem cells</kwd><kwd>reparation</kwd><kwd>traumatology</kwd><kwd>bone</kwd><kwd>cartilage</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yorukoglu AC, Kiter AE, Akkaya S, Satiroglu-Tufan NL, Tufan AC. A concise review on the use of mesenchymal stem cells in cell sheet-based tissue engineering with special emphasis on bone tissue regeneration. Stem Cells Int. 2017; 2017: 2374161. doi: 10.1155/2017/2374161</mixed-citation><mixed-citation xml:lang="en">Yorukoglu AC, Kiter AE, Akkaya S, Satiroglu-Tufan NL, Tufan AC. A concise review on the use of mesenchymal stem cells in cell sheet-based tissue engineering with special emphasis on bone tissue regeneration. Stem Cells Int. 2017; 2017: 2374161. doi: 10.1155/2017/2374161</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bhardwaj N, Chouhan D, Mandal BB. Tissue engineered skin and wound healing: Current strategies and future directions. Curr Pharm Des. 2017; 23(24): 3455-3482. doi: 10.2174/1381612823666170526094606</mixed-citation><mixed-citation xml:lang="en">Bhardwaj N, Chouhan D, Mandal BB. Tissue engineered skin and wound healing: Current strategies and future directions. Curr Pharm Des. 2017; 23(24): 3455-3482. doi: 10.2174/1381612823666170526094606</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tarassoli SP, Jessop ZM, Al-Sabah A, Gao N, Whitaker S, Doak S, Whitaker IS. Skin tissue engineering using 3D bioprinting: An evolving research field. Plast Reconstr Aesthet Surg. 2018; 71(5): 615-623. doi: 10.1016/j.bjps.2017.12.006</mixed-citation><mixed-citation xml:lang="en">Tarassoli SP, Jessop ZM, Al-Sabah A, Gao N, Whitaker S, Doak S, Whitaker IS. Skin tissue engineering using 3D bioprinting: An evolving research field. Plast Reconstr Aesthet Surg. 2018; 71(5): 615-623. doi: 10.1016/j.bjps.2017.12.006</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Modugno FD, Colosi C, Trono P, Antonacci G, Ruocco G, Nisticò P. 3D models in the new era of immune oncology: focus on T cells, CAF and ECM. J Exp Clin Cancer Res. 2019; 38(1): 117. doi: 10.1186/s13046-019-1086-2</mixed-citation><mixed-citation xml:lang="en">Modugno FD, Colosi C, Trono P, Antonacci G, Ruocco G, Nisticò P. 3D models in the new era of immune oncology: focus on T cells, CAF and ECM. J Exp Clin Cancer Res. 2019; 38(1): 117. doi: 10.1186/s13046-019-1086-2</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt SK, Schmid R, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK. Tumor cells develop defined cellular phenotypes after 3D-bioprinting in different bioinks. Cells. 2019; 8(10): 1295. doi: 10.3390/cells8101295</mixed-citation><mixed-citation xml:lang="en">Schmidt SK, Schmid R, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK. Tumor cells develop defined cellular phenotypes after 3D-bioprinting in different bioinks. Cells. 2019; 8(10): 1295. doi: 10.3390/cells8101295</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sun Q, Barz M, De Geest BG, Diken M, Hennink WE, Kiessling F, Lammers T, Shi Y. Nanomedicine and macroscale materials in immuno-oncology. Chem Soc Rev. 2019; 48(1): 351-381. doi: 10.1039/c8cs00473k</mixed-citation><mixed-citation xml:lang="en">Sun Q, Barz M, De Geest BG, Diken M, Hennink WE, Kiessling F, Lammers T, Shi Y. Nanomedicine and macroscale materials in immuno-oncology. Chem Soc Rev. 2019; 48(1): 351-381. doi: 10.1039/c8cs00473k</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Shevchenko IL. Cellular technologies in cardiology. Vestn Ross Akad Med Nauk. 2003; 11: 6-10.</mixed-citation><mixed-citation xml:lang="en">Shevchenko IL. Cellular technologies in cardiology. Vestn Ross Akad Med Nauk. 2003; 11: 6-10.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Duran AG, Reidell O, Stachelscheid H, Klose K, Gossen M, Falk V, Röll W, Stamm C. Regenerative medicine/cardiac cell therapy: Pluripotent stem cells. Thorac Cardiovasc Surg. 2018; 66(1): 53-62. doi: 10.1055/s-0037-1608761</mixed-citation><mixed-citation xml:lang="en">Duran AG, Reidell O, Stachelscheid H, Klose K, Gossen M, Falk V, Röll W, Stamm C. Regenerative medicine/cardiac cell therapy: Pluripotent stem cells. Thorac Cardiovasc Surg. 2018; 66(1): 53-62. doi: 10.1055/s-0037-1608761</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Goradel NH, Ghiyami-Hour F, Negahdari B, Malekshahi ZV, Hashemzehi M, Masoudifar A, Mirzaei H. Stem cell therapy: A new therapeutic option for cardiovascular diseases. J Cell Biochem. 2018; 119(1): 95-104. doi: 10.1002/jcb.26169</mixed-citation><mixed-citation xml:lang="en">Goradel NH, Ghiyami-Hour F, Negahdari B, Malekshahi ZV, Hashemzehi M, Masoudifar A, Mirzaei H. Stem cell therapy: A new therapeutic option for cardiovascular diseases. J Cell Biochem. 2018; 119(1): 95-104. doi: 10.1002/jcb.26169</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Taoufik E, Kouroupi G, Zygogianni O, Matsas R. Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models. Open Biol. 2018; 8(9): 180138. doi: 10.1098/rsob.180138</mixed-citation><mixed-citation xml:lang="en">Taoufik E, Kouroupi G, Zygogianni O, Matsas R. Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models. Open Biol. 2018; 8(9): 180138. doi: 10.1098/rsob.180138</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nuñez J, Vignoletti F, Caffesse RG, Sanz M. Cellular therapy in periodontal regeneration. Periodontol 2000. 2019; 79(1): 107-116. doi: 10.1111/prd.12250</mixed-citation><mixed-citation xml:lang="en">Nuñez J, Vignoletti F, Caffesse RG, Sanz M. Cellular therapy in periodontal regeneration. Periodontol 2000. 2019; 79(1): 107-116. doi: 10.1111/prd.12250</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shan LH, An XY, Xu MM, Fan SP, Zhong H, Ni P, Chi H. Analysis on the trend of innovation and development in the field of ophthalmology. Zhonghua Yan Ke Za Zhi. 2018; 54(6): 452-463. doi: 10.3760/cma.j.issn.0412-4081.2018.06.012</mixed-citation><mixed-citation xml:lang="en">Shan LH, An XY, Xu MM, Fan SP, Zhong H, Ni P, Chi H. Analysis on the trend of innovation and development in the field of ophthalmology. Zhonghua Yan Ke Za Zhi. 2018; 54(6): 452-463. doi: 10.3760/cma.j.issn.0412-4081.2018.06.012</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Millman JR, Pagliuca FW. Autologous pluripotent stem cell-derived β-like cells for diabetes cellular therapy. Diabetes. 2017; 66(5): 1111-1120. doi: 10.2337/db16-1406</mixed-citation><mixed-citation xml:lang="en">Millman JR, Pagliuca FW. Autologous pluripotent stem cell-derived β-like cells for diabetes cellular therapy. Diabetes. 2017; 66(5): 1111-1120. doi: 10.2337/db16-1406</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Arber C, Lovejoy C, Wray S. Stem cell models of Alzheimer’s disease: Progress and challenges. Alzheimers Res Ther. 2017; 9(1): 42. doi: 10.1186/s13195-017-0268-4</mixed-citation><mixed-citation xml:lang="en">Arber C, Lovejoy C, Wray S. Stem cell models of Alzheimer’s disease: Progress and challenges. Alzheimers Res Ther. 2017; 9(1): 42. doi: 10.1186/s13195-017-0268-4</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Акопян А.С., Белоусов Д.Ю., Рысулы М.Р., Куликов А.В. Некоторые актуальные проблемы клинических исследований стволовых клеток. Качественная клиническая практика. 2010; (1): 22-28.</mixed-citation><mixed-citation xml:lang="en">Akopyan AS, Belousov DYu, Rysuly MR, Kulikov AV. Some current problems of stem cell clinical research. Kachestvennaya klinicheskaya praktika. 2010; (1): 22-28. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Miguel-Beriain I. The ethics of stem cells revisited. Adv Drug Deliv Rev. 2015; 82-83: 176-80. doi: 10.1016/j.addr.2014.11.011</mixed-citation><mixed-citation xml:lang="en">Miguel-Beriain I. The ethics of stem cells revisited. Adv Drug Deliv Rev. 2015; 82-83: 176-80. doi: 10.1016/j.addr.2014.11.011</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lavazza A, Massimini M. Cerebral organoids: ethical issues and consciousness assessment. J Med Ethics. 2018; 44(9): 606-610. doi: 10.1136/medethics-2017-104555</mixed-citation><mixed-citation xml:lang="en">Lavazza A, Massimini M. Cerebral organoids: ethical issues and consciousness assessment. J Med Ethics. 2018; 44(9): 606-610. doi: 10.1136/medethics-2017-104555</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Petrini C. Bioethics of clinical applications of stem cells. Int J Mol Sci. 2017; 18(4): 814. doi: 10.3390/ijms18040814</mixed-citation><mixed-citation xml:lang="en">Petrini C. Bioethics of clinical applications of stem cells. Int J Mol Sci. 2017; 18(4): 814. doi: 10.3390/ijms18040814</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng YL. Some ethical concerns about human induced pluripotent stem cells. Sci Eng Ethics. 2016; 22(5): 1277-1284. doi: 10.1007/s11948-015-9693-6</mixed-citation><mixed-citation xml:lang="en">Zheng YL. Some ethical concerns about human induced pluripotent stem cells. Sci Eng Ethics. 2016; 22(5): 1277-1284. doi: 10.1007/s11948-015-9693-6</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Aulisio MP. Double effect, principle or doctrine of. In: Jennings B. (editor) Bioethics. Gale: Farminton Hills, MI, USA. 2014; 2: 889-894.</mixed-citation><mixed-citation xml:lang="en">Aulisio MP. Double effect, principle or doctrine of. In: Jennings B. (editor) Bioethics. Gale: Farminton Hills, MI, USA. 2014; 2: 889-894.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Деев Р.В., Исаев А.А., Кочиш А.Ю., Тихилов P.M. Клеточные технологии в травматологии и ортопедии: пути развития. Клеточная трансплантология и тканевая инженерия. 2007; 2(4): 18-30.</mixed-citation><mixed-citation xml:lang="en">Deev RV, Isaev AA, Kochish AY, Tikhilov RM. Cellular technologies in traumatology and orthopedics: ways of development. Kletochnaya transplantologiya i tkanevaya inzheneriya. 2007; 2(4): 18-30. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Mills LA, Aitken SA, Simpson RWAH. The risk of nonunion per fracture: Current myths and revised figures from a population of over 4 million adults. Acta Orthop. 2017; 88(4): 434-439. doi: 10.1080/17453674.2017.1321351</mixed-citation><mixed-citation xml:lang="en">Mills LA, Aitken SA, Simpson RWAH. The risk of non-union per fracture: Current myths and revised figures from a population of over 4 million adults. Acta Orthop. 2017; 88(4): 434-439. doi: 10.1080/17453674.2017.1321351</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gómez-Barrena E, Rosset P, Lozano D, Stanovici J, Ermthaller C, Gerbhard F. Bone fracture healing: Cell therapy in delayed unions and nonunions. Bone. 2015; 70: 93-101. doi: 10.1016/j.bone.2014.07.033</mixed-citation><mixed-citation xml:lang="en">Gómez-Barrena E, Rosset P, Lozano D, Stanovici J, Ermthaller C, Gerbhard F. Bone fracture healing: Cell therapy in delayed unions and nonunions. Bone. 2015; 70: 93-101. doi: 10.1016/j.bone.2014.07.033</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fernández-Hernández O. Terapias para el hueso: Sustitutivos óseos. Mon Act Soc Esp Med Cir Pie Tobillo. 2017; 9: 45-53.</mixed-citation><mixed-citation xml:lang="en">Fernández-Hernández O. Terapias para el hueso: Sustitutivos óseos. Mon Act Soc Esp Med Cir Pie Tobillo. 2017; 9: 45-53.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kemper N, Davison N, Fitzpatrick D, Marshall R, Lin A, Mundy K, Cobb RR. Characterization of the mechanical properties of bovine cortical bone treated with a novel tissue sterilization process. Cell Tissue Bank. 2011; 12(4): 273-279. doi: 10.1007/s10561-010-9191-7</mixed-citation><mixed-citation xml:lang="en">Kemper N, Davison N, Fitzpatrick D, Marshall R, Lin A, Mundy K, Cobb RR. Characterization of the mechanical properties of bovine cortical bone treated with a novel tissue sterilization process. Cell Tissue Bank. 2011; 12(4): 273-279. doi: 10.1007/s10561-010-9191-7</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mayer Y, Ginesin O, Khutaba A, Machtei EE, Giladi HZ. Biocompatibility and osteoconductivity of PLCL coated and noncoated xenografts: An in vitro and preclinical trial. Clin Implant Dent Relat Res. 2018; 20(3): 294-299. doi: 10.1111/cid.12596</mixed-citation><mixed-citation xml:lang="en">Mayer Y, Ginesin O, Khutaba A, Machtei EE, Giladi HZ. Biocompatibility and osteoconductivity of PLCL coated and noncoated xenografts: An in vitro and preclinical trial. Clin Implant Dent Relat Res. 2018; 20(3): 294-299. doi: 10.1111/cid.12596</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Qiao W, Liu R, Li Z, Luo X, Huang B, Liu Q, Chen Z, Tsoi JKH, Su Y-X, Cheung KMC, Matinlinna JP, Yeung KWK, Chen Z. Contribution of the in situ release of endogenous cations from xenograft bone driven by fluoride incorporation toward enhanced bone regeneration. Biomater Sci. 2018; 6(11): 2951-2964. doi: 10.1039/c8bm00910d</mixed-citation><mixed-citation xml:lang="en">Qiao W, Liu R, Li Z, Luo X, Huang B, Liu Q, Chen Z, Tsoi JKH, Su Y-X, Cheung KMC, Matinlinna JP, Yeung KWK, Chen Z. Contribution of the in situ release of endogenous cations from xenograft bone driven by fluoride incorporation toward enhanced bone regeneration. Biomater Sci. 2018; 6(11): 2951-2964. doi: 10.1039/c8bm00910d</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Arpağ OF, Damlar I, Altan A, Tatli U, Günay A. To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model. J Appl Oral Sci. 2018; 26: 20170004. doi: 10.1590/1678-7757-2017-0004</mixed-citation><mixed-citation xml:lang="en">Arpağ OF, Damlar I, Altan A, Tatli U, Günay A. To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model. J Appl Oral Sci. 2018; 26: 20170004. doi: 10.1590/1678-7757-2017-0004</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Laurencin C, Khan Y, El-Amin SF. Bone graft substitutes (Review). Expert Review of Medical Devices. 2006; 3(1): 49-57. doi: 10.1586/17434440.3.1.49.</mixed-citation><mixed-citation xml:lang="en">Laurencin C, Khan Y, El-Amin SF. Bone graft substitutes (Review). Expert Review of Medical Devices. 2006; 3(1): 49-57. doi: 10.1586/17434440.3.1.49.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ma D, Ren L, Liu Y, Chen F, Zhang J, Xue Z, Mao T. Engineering scaffold-free bone tissue using bone marrow stromal cell sheets. J Orthop Res. 2010; 28(5): 697-702. doi: 10.1002/jor.21012</mixed-citation><mixed-citation xml:lang="en">Ma D, Ren L, Liu Y, Chen F, Zhang J, Xue Z, Mao T. Engineering scaffold-free bone tissue using bone marrow stromal cell sheets. J Orthop Res. 2010; 28(5): 697-702. doi: 10.1002/jor.21012</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz-Rodriguez P, López-Álvarez M, Serra J, González P, Landín M. Current stage of marine ceramic grafts for 3D bone tissue regeneration. Mar Drugs. 2019; 17(8): 471. doi: 10.3390/md17080471</mixed-citation><mixed-citation xml:lang="en">Diaz-Rodriguez P, López-Álvarez M, Serra J, González P, Landín M. Current stage of marine ceramic grafts for 3D bone tissue regeneration. Mar Drugs. 2019; 17(8): 471. doi: 10.3390/md17080471</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Fu K, Xu Q, Czernuszka J, Triffitt JT, Xia Z. Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation. Biomed Mater. 2013; 8(6): 065007. doi: 10.1088/1748-6041/8/6/065007</mixed-citation><mixed-citation xml:lang="en">Fu K, Xu Q, Czernuszka J, Triffitt JT, Xia Z. Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation. Biomed Mater. 2013; 8(6): 065007. doi: 10.1088/1748-6041/8/6/065007</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang G, Brion A, Willemin A-S, Piet M-H, Moby V, Bianchi A, Mainard D, Galois L, Gillet P, Rousseau M. Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution. J Biomed Mater Res A. 2017; 105(2): 662-671. doi: 10.1002/jbm.a.35939</mixed-citation><mixed-citation xml:lang="en">Zhang G, Brion A, Willemin A-S, Piet M-H, Moby V, Bianchi A, Mainard D, Galois L, Gillet P, Rousseau M. Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution. J Biomed Mater Res A. 2017; 105(2): 662-671. doi: 10.1002/jbm.a.35939</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Шаманская Т.В., Осипова Е.Ю., Румянцев С.А. Технологии культивирования мезенхимальных стволовых клеток ex vivo для клинического использования. Онкогематология. 2009; 3: 69-76.</mixed-citation><mixed-citation xml:lang="en">Shamanskaya TV, Osipova EYu, Rumyantsev SA. Ex vivo mesenchymal stem cell culture technologies for clinical use. Onkogematologiya. 2009; 3: 69-76. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Koga H, Engebretsen L, Brinchmann JE, Muneta T, Sekiya I. Mesenchymal stem cell-based therapy for cartilage repair: A review. Knee Surg Sports Traumatol Arthrosc. 2009; 17(11): 1289-1297. doi: 10.1007/s00167-009-0782-4</mixed-citation><mixed-citation xml:lang="en">Koga H, Engebretsen L, Brinchmann JE, Muneta T, Sekiya I. Mesenchymal stem cell-based therapy for cartilage repair: A review. Knee Surg Sports Traumatol Arthrosc. 2009; 17(11): 1289-1297. doi: 10.1007/s00167-009-0782-4</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol. 1976; 4: 267-274.</mixed-citation><mixed-citation xml:lang="en">Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol. 1976; 4: 267-274.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991; 9: 641-650.</mixed-citation><mixed-citation xml:lang="en">Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991; 9: 641-650.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Лупатов А.Ю., Вдовин А.С., Вахрушев И.В., Полтавцева Р.А., Ярыгин К.Н. Сравнительный анализ экспрессии поверхностных маркеров на фибробластах и фибробластоподобных клетках, выделенных из различных тканей человека. Клеточные технологии в биологии и медицине. 2014; 4: 221-228.</mixed-citation><mixed-citation xml:lang="en">Lupatov AYu, Vdovin AS, Vakhrushev IV, Poltavtseva RA, Yarygin KN. Comparative analysis of the expression of surface markers on fibroblasts and fibroblast-like cells isolated from various human tissues. Kletochnye tekhnologii v biologii i meditsine. 2014; 4: 221-228. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Shurygin MG, Shurygina IA, Dremina NN, Kanya OV. Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor. Bulletin of Experimental Biology and Medicine. 2015; 158(4): 528-531.</mixed-citation><mixed-citation xml:lang="en">Shurygin MG, Shurygina IA, Dremina NN, Kanya OV. Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor. Bulletin of Experimental Biology and Medicine. 2015; 158(4): 528-531.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007; 110(10): 3499-3506. doi: 10.1182/blood-2007-02-069716</mixed-citation><mixed-citation xml:lang="en">Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007; 110(10): 3499-3506. doi: 10.1182/blood-2007-02-069716</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Mushahary D, Spittler A, Kasper C, Weber V, Charwat V. Isolation, cultivation, and characterization of human mesenchymal stem cells. Cytometry A. 2018; 93(1): 19- 31. doi: 10.1002/cyto.a.23242</mixed-citation><mixed-citation xml:lang="en">Mushahary D, Spittler A, Kasper C, Weber V, Charwat V. Isolation, cultivation, and characterization of human mesenchymal stem cells. Cytometry A. 2018; 93(1): 19-31. doi: 10.1002/cyto.a.23242</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kolaparthy LK, Sanivarapu S, Moogla S, Kutcham RS. Adipose tissue‐adequate, accessible regenerative material. Int J Stem Cells. 2015; 8: 121-127.</mixed-citation><mixed-citation xml:lang="en">Kolaparthy LK, Sanivarapu S, Moogla S, Kutcham RS. Adipose tissue‐adequate, accessible regenerative material. Int J Stem Cells. 2015; 8: 121-127.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Peng L, Li H, Gu L, Peng X-M, Huang Y-S, Gao Z-L. Comparison of biological characteristics of marrow mesenchymal stem cells in hepatitis B patients and normal adults. World J Gastroenterol. 2007; 13(11): 1743-1746. doi: 10.3748/wjg.v13.i11.1743</mixed-citation><mixed-citation xml:lang="en">Peng L, Li H, Gu L, Peng X-M, Huang Y-S, Gao Z-L. Comparison of biological characteristics of marrow mesenchymal stem cells in hepatitis B patients and normal adults. World J Gastroenterol. 2007; 13(11): 1743-1746. doi: 10.3748/wjg.v13.i11.1743</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Seebach C, Henrich D, Tewksbury R, Wilhelm K, Marzi I. Number and proliferative capacity of human mesenchymal stem cells are modulated positively in multiple trauma patients and negatively in atrophic nonunions. Calcif Tissue Int. 2007; 80(4): 294-300. doi: 10.1007/s00223-007-9020-6</mixed-citation><mixed-citation xml:lang="en">Seebach C, Henrich D, Tewksbury R, Wilhelm K, Marzi I. Number and proliferative capacity of human mesenchymal stem cells are modulated positively in multiple trauma patients and negatively in atrophic nonunions. Calcif Tissue Int. 2007; 80(4): 294-300. doi: 10.1007/s00223-007-9020-6</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003; 33(6): 919-926. doi: 10.1016/j.bone.2003.07.005</mixed-citation><mixed-citation xml:lang="en">Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003; 33(6): 919-926. doi: 10.1016/j.bone.2003.07.005</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, Kortesidis A, Simmons PJ. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci. 2003; 116(9): 1827-1835. doi: 10.1242/jcs.00369</mixed-citation><mixed-citation xml:lang="en">Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, Kortesidis A, Simmons PJ. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci. 2003; 116(9): 1827-1835. doi: 10.1242/jcs.00369</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells: the International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4): 315-317. doi: 10.1080/14653240600855905</mixed-citation><mixed-citation xml:lang="en">Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells: the International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4): 315-317. doi: 10.1080/14653240600855905</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Ning H, Lin G, Lue TF, Lin C-S. Mesenchymal stem cell marker Stro-1 is a 75kd endothelial antigen. Biochem Biophys Res Commun. 2011; 413(2): 353-357. doi: 10.1016/j.bbrc.2011.08.104</mixed-citation><mixed-citation xml:lang="en">Ning H, Lin G, Lue TF, Lin C-S. Mesenchymal stem cell marker Stro-1 is a 75kd endothelial antigen. Biochem Biophys Res Commun. 2011; 413(2): 353-357. doi: 10.1016/j.bbrc.2011.08.104</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Nakamura A, Akahane M, Shigematsu H, Tadokoro M, Morita Y, Ohgushi H, Dohi Y, Imamura T. Cell sheet transplantation of cultured mesenchymal stem cells enhances bone formation in a rat nonunion model. Bone. 2010; 46(2): 418-424. doi: 10.1016/j.bone.2009.08.048</mixed-citation><mixed-citation xml:lang="en">Nakamura A, Akahane M, Shigematsu H, Tadokoro M, Morita Y, Ohgushi H, Dohi Y, Imamura T. Cell sheet transplantation of cultured mesenchymal stem cells enhances bone formation in a rat nonunion model. Bone. 2010; 46(2): 418-424. doi: 10.1016/j.bone.2009.08.048</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Yim RL-H, Lee JT-Y, Bow CH, Meij B, Leung V, Cheung KMC, Vavken P, Samartzis D. A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: Insights and future directions for regenerative therapeutics. Stem Cells Dev. 2014; 23(21): 2553-2567. doi: 10.1089/scd.2014.0203</mixed-citation><mixed-citation xml:lang="en">Yim RL-H, Lee JT-Y, Bow CH, Meij B, Leung V, Cheung KMC, Vavken P, Samartzis D. A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: Insights and future directions for regenerative therapeutics. Stem Cells Dev. 2014; 23(21): 2553-2567. doi: 10.1089/scd.2014.0203</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Shimizu T, Yamato M, Kikuchi A, Okano T. Cell sheet engineering for myocardial tissue reconstruction. Biomaterials. 2003; 24(13): 2309-2316. doi: 10.1016/s0142-9612(03)00110-8</mixed-citation><mixed-citation xml:lang="en">Shimizu T, Yamato M, Kikuchi A, Okano T. Cell sheet engineering for myocardial tissue reconstruction. Biomaterials. 2003; 24(13): 2309-2316. doi: 10.1016/s0142-9612(03)00110-8</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Owaki T, Shimizu T, Yamato M, Okano T. Cell sheet engineering for regenerative medicine: Current challenges and strategies. Biotechnol J. 2014; 9(7): 904-914. doi: 10.1002/biot.201300432</mixed-citation><mixed-citation xml:lang="en">Owaki T, Shimizu T, Yamato M, Okano T. Cell sheet engineering for regenerative medicine: Current challenges and strategies. Biotechnol J. 2014; 9(7): 904-914. doi: 10.1002/biot.201300432</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Радеева И.Ф., Думченко Н.Б., Нечаева Е.А. Культивирование клеток на микроносителях в биореакторах. Вестник ПНИПУ. Химическая технология и биотехнология. 2019; 2: 22-32. doi: 10-15593/2224-9400/2019.2.02</mixed-citation><mixed-citation xml:lang="en">Radeeva IF, Dumchenko NB, Nechaeva EA. Cell culture on microcarriers in bioreactors. Vestnik PNIPU. Khimicheskaya tekhnologiya i biotekhnologiya. 2019; 2: 22-32. doi: 10-15593/2224-9400/2019.2.02</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Kwon OH, Kikuchi A, Yamato M, Sakurai Y, Okano T. Rapid cell sheet detachment from poly(N- isopropylacrylamide)-grafted porous cell culture membranes. J Biomed Mater Res. 2000; 50(1): 82-89. doi: 10.1002/(sici)1097-4636(200004)50:1&lt;82::aidjbm12&gt;3.0.co;2-7</mixed-citation><mixed-citation xml:lang="en">Kwon OH, Kikuchi A, Yamato M, Sakurai Y, Okano T. Rapid cell sheet detachment from poly(N-isopropylacrylamide)-grafted porous cell culture membranes.J Biomed Mater Res. 2000; 50(1): 82-89. doi: 10.1002/(sici)1097-4636(200004)50:1&lt;82::aid-jbm12&gt;3.0.co;2-7</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Calve S, Dennis RG, Kosnik PE, Baar K, Grosh K, Arruda EM. Engineering of functional tendon. Tissue Eng. 2004; 10(5-6): 755-761. doi: 10.1089/1076327041348464</mixed-citation><mixed-citation xml:lang="en">Calve S, Dennis RG, Kosnik PE, Baar K, Grosh K, Arruda EM. Engineering of functional tendon. Tissue Eng. 2004; 10(5-6): 755-761. doi: 10.1089/1076327041348464</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Murdoch AD, Grady LM, Ablett MP, Katopodi T, Meadows RS, Hardingham TE. Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage. Stem Cells. 2007; 25(11): 2786-2796. doi: 10.1634/stemcells.2007-0374</mixed-citation><mixed-citation xml:lang="en">Murdoch AD, Grady LM, Ablett MP, Katopodi T, Meadows RS, Hardingham TE. Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage. Stem Cells. 2007; 25(11): 2786-2796. doi: 10.1634/stemcells.2007-0374</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Sakaguchi K, Shimizu T, Okano T. Construction of three-dimensional vascularized cardiac tissue with cell sheet engineering. J Control Release. 2015; 205: 83-88. doi: 10.1016/j.jconrel.2014.12.016</mixed-citation><mixed-citation xml:lang="en">Sakaguchi K, Shimizu T, Okano T. Construction of threedimensional vascularized cardiac tissue with cell sheet engineering. J Control Release. 2015; 205: 83-88. doi: 10.1016/j.jconrel.2014.12.016</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">L’Heureux N, McAllister TN, de la Fuente LM. Tissueengineered blood vessel for adult arterial revascularization. N Engl J Med. 2007; 357(14): 1451-1453. doi: 10.1056/NEJMc071536</mixed-citation><mixed-citation xml:lang="en">L’Heureux N, McAllister TN, de la Fuente LM. Tissueengineered blood vessel for adult arterial revascularization. N Engl J Med. 2007; 357(14): 1451-1453. doi: 10.1056/NEJMc071536</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Masuda S, Shimizu T, Yamato M, Okano T. Cell sheet engineering for heart tissue repair. Adv Drug Deliv Rev. 2008; 60(2): 277-285. doi: 10.1016/j.addr.2007.08.031</mixed-citation><mixed-citation xml:lang="en">Masuda S, Shimizu T, Yamato M, Okano T. Cell sheet engineering for heart tissue repair. Adv Drug Deliv Rev. 2008; 60(2): 277-285. doi: 10.1016/j.addr.2007.08.031</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Bornes TD, Adesida AB, Jomha NM. Mesenchymal stem cells in the treatment of traumatic articular cartilage defects: a comprehensive review. Arthritis Res Ther. 2014; 16(5): 432. doi: 10.1186/s13075-014-0432-1</mixed-citation><mixed-citation xml:lang="en">Bornes TD, Adesida AB, Jomha NM. Mesenchymal stem cells in the treatment of traumatic articular cartilage defects: a comprehensive review. Arthritis Res Ther. 2014; 16(5): 432. doi: 10.1186/s13075-014-0432-1</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Lubis AMT, Lubis VK. Adult bone marrow stem cells in cartilage therapy. Acta Medica Indonesiana. 2012; 44(1): 62-68.</mixed-citation><mixed-citation xml:lang="en">Lubis AMT, Lubis VK. Adult bone marrow stem cells in cartilage therapy. Acta Medica Indonesiana. 2012; 44(1): 62-68.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Gudas R, Gudaite A, Pocius A, Gudiene A, Cekanauskas E, Monastyreckiene E, Basevicius A. Ten-year follow-up of a prospective, randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint of athletes. Am J Sports Med. 2012; 40(11): 2499-508. doi: 10.1177/0363546512458763</mixed-citation><mixed-citation xml:lang="en">Gudas R, Gudaite A, Pocius A, Gudiene A, Cekanauskas E, Monastyreckiene E, Basevicius A. Ten-year follow-up of a prospective, randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint of athletes. Am J Sports Med. 2012; 40(11): 2499-508. doi: 10.1177/0363546512458763</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Levy YD, Görtz S, Pulido PA, McCauley JC, Bugbee WD. Do fresh osteochondral allografts successfully treat femoral condyle lesions? Clin Orthop Relat Res. 2013; 471(1): 231-237. doi: 10.1007/s11999-012-2556-4</mixed-citation><mixed-citation xml:lang="en">Levy YD, Görtz S, Pulido PA, McCauley JC, Bugbee WD. Do fresh osteochondral allografts successfully treat femoral condyle lesions? Clin Orthop Relat Res. 2013; 471(1): 231-237. doi: 10.1007/s11999-012-2556-4</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Kon E, Filardo G, Berruto M, Benazzo F, Zanon G, Villa SD, Marcacci M. Articular cartilage treatment in high-level male soccer players: A prospective comparative study of arthroscopic second-generation autologous chondrocyte implantation versus microfracture. Am J Sports Med. 2011; 39(12): 2549-2557. doi: 10.1177/0363546511420688</mixed-citation><mixed-citation xml:lang="en">Kon E, Filardo G, Berruto M, Benazzo F, Zanon G, Villa SD, Marcacci M. Articular cartilage treatment in high-level male soccer players: A prospective comparative study of arthroscopic second-generation autologous chondrocyte implantation versus microfracture. Am J Sports Med. 2011; 39(12): 2549-2557. doi: 10.1177/0363546511420688</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Chavez RD, Serra R. Scaffoldless tissue-engineered cartilage for studying transforming growth factor beta- mediated cartilage formation. Biotechnol Prog. 2020; 36(1): 2897. doi: 10.1002/btpr.2897</mixed-citation><mixed-citation xml:lang="en">65 Chavez RD, Serra R. Scaffoldless tissue-engineered cartilage for studying transforming growth factor beta-mediated cartilage formation. Biotechnol Prog. 2020; 36(1): 2897. doi: 10.1002/btpr.2897</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 1998; 238: 265-272. doi: 10.1006/excr.1997.3858</mixed-citation><mixed-citation xml:lang="en">Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 1998; 238: 265-272. doi: 10.1006/excr.1997.3858</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Tew SR, Murdoch AD, Rauchenberg RP, Hardingham TE. Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells. Methods. 2008; 45(1): 2–9. doi: 10.1016/j.ymeth.2008.01.006</mixed-citation><mixed-citation xml:lang="en">Tew SR, Murdoch AD, Rauchenberg RP, Hardingham TE. Cellular methods in cartilage research: Primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells. Methods. 2008; 45(1): 2–9. doi: 10.1016/j.ymeth.2008.01.006</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Szychlinska MA, Calabrese G, Ravalli S, Parrinello NL, Forte S, Castrogiovanni P, Pricoco E, Imbesi R, Castorina S, Leonardi R, Rosa MD, Musumeci G. Cycloastragenol as an exogenous enhancer of chondrogenic differentiation of human adiposederived mesenchymal stem cells. A morphological study. Cells. 2020; 9(2): 347. doi: 10.3390/cells9020347</mixed-citation><mixed-citation xml:lang="en">Szychlinska MA, Calabrese G, Ravalli S, Parrinello NL, Forte S, Castrogiovanni P, Pricoco E, Imbesi R, Castorina S, Leonardi R, Rosa MD, Musumeci G. Cycloastragenol as an exogenous enhancer of chondrogenic differentiation of human adiposederived mesenchymal stem cells. A morphological study. Cells. 2020; 9(2): 347. doi: 10.3390/cells9020347</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011; 19(10): 1210-1218. doi: 10.1016/j.joca.2011.07.005</mixed-citation><mixed-citation xml:lang="en">Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured threedimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011; 19(10): 1210-1218. doi: 10.1016/j.joca.2011.07.005</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
