actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2020-5.6.7actabiomedica-2496Research ArticleГЕНЕТИКА, ПРОТЕОМИКА И МЕТАБОЛОМИКАGENETICS, PROTEOMICS AND METABOLOMICSАссоциации полиморфизмов гена интерлейкина-10 с язвенным колитомAssociation of Interleukin-10 Gene Polymorphisms with Ulcerative Colitishttps://orcid.org/0000-0002-2405-0198ЖилинИ. В.ZhilinI. V.

врач-колопроктолог, аспирант

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

zhivoj1113@yandex.ruhttps://orcid.org/0000-0002-7953-6523ЧашковаЕ. Ю.ChashkovaE. Yu.

кандидат медицинских наук, врач-колопроктолог, заведующая лабораторией реконструктивной хирургии научного отдела клинической хирургии

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

iscst@mail.ruhttps://orcid.org/0000-0002-4405-2975ЖилинаА. А.ZhilinaA. A.

кандидат медицинских наук, доцент кафедры терапии ФПК и ППС

672000, г. Чита, ул. Горького, 39А, Россия

Cand. Sc. (Med.), Assistant Professor at the Department of Therapy of the Faculty of Advanced Training and Staff Retraining

Gorkogo str. 39A, Chita 672000, Russian Federation

https://orcid.org/0000-0001-9918-4417МарковскийА. В.MarkovskiyA. V.

младший научный сотрудник лаборатории молекулярной генетики Научно-исследовательского института молекулярной медицины

672000, г. Чита, ул. Горького, 39А, Россия

Gorkogo str. 39A, Chita 672000, Russian Federation

https://orcid.org/0000-0003-1862-421XКимА. Д.KimA. D.

врач-хирург, младший научный сотрудник лаборатории реконструктивной хирургии научного отдела клинической хирургии

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

iscst@mail.ruФГБНУ «Иркутский научный центр хирургии и травматологии»Irkutsk Scientific Centre of Surgery and TraumatologyФГБОУ ВО «Читинская государственная медицинская академия» Минздрава РоссииChita State Medical Academy202014012021565865Copyright © Жилин И.В., Чашкова Е.Ю., Жилина А.А., Марковский А.В., Ким А.Д., 20212021Жилин И.В., Чашкова Е.Ю., Жилина А.А., Марковский А.В., Ким А.Д.Zhilin I.V., Chashkova E.Y., Zhilina A.A., Markovskiy A.V., Kim A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/2496

Представленный обзор литературы посвящён изучению роли полиморфных вариантов гена противовоспалительного интерлейкина-10 (Interleukin-10, IL-10) в этиологии и патогенезе язвенного колита у пациентов различных этнических групп.

Цель

Цель. Обобщить результаты, полученные из электронных баз данных, по изучению особенностей течения язвенного колита у пациентов разных этнических групп с учётом носительства полиморфизмов гена IL10.

Материалы и методы

Материалы и методы. Выбрано 25 исследований, в том числе 4 метаанализа, посвящённых изучению ассоциативных связей однонуклеотидных полиморфизмов (single nucleotide polymorphism, SNP) гена IL10, выделенного из образцов крови, в позициях -592АА/СА, -819СТ, -1082АА/GA и rs3024505 в развитии и течении язвенного колита.

Результаты

Результаты. Ряд исследователей из Европы, Саудовской Аравии сообщают о повышенной частоте встречаемости язвенного колита среди носителей SNP IL10-1082AА и низкой у носителей -592АА. Положительные ассоциации IL10-819CT с  распространённостью язвенного колита представлены в единичных сообщениях из Европы, Ближнего Востока и в ряде исследований из Азиатских стран. Однако  выявленные ассоциации даже в пределах одной популяции нередко носят противоречивый характер. Возможно, разночтения обусловлены этнической  гетерогенностью групп в рассматриваемых когортах, в связи с чем необходимо продолжать эпидемиологические исследования с большим объёмом выборки в  конкретных географических зонах.

This literature review is devoted to the study of the role of polymorphic variants of the anti-inflammatory interleukin-10 gene (Interleukin-10, IL10) in the etiology and pathogenesis of ulcerative colitis in patients of various ethnic groups.

Aim

Aim. To generalize the results obtained from electronic databases on the study of the characteristics of the course of ulcerative colitis in patients of different ethnic groups, taking into account the carriage of IL10 gene polymorphisms.

Materials and methods

Materials and methods. Twenty-five studies were selected, including four meta-analyzes devoted to the  study of associative relationships of single nucleotide polymorphisms (SNPs) of the IL10 gene isolated from  blood samples at positions -592AA/CA, -819CT, -1082АА/GA, and rs3024505 in the development and course of ulcerative colitis.

Results

Results. A number of researchers from Europe, Saudi Arabia report an increased incidence of ulcerative colitis among carriers of the IL10-1082AA SNP and a low incidence among carriers of -592AA. Positive associations of IL10-819CT with the prevalence of ulcerative colitis are presented in single reports from Europe, the Middle East and in a number of studies from Asian countries. However, the identified associations, even within the  same population, are often contradictory. Perhaps the discrepancies are due to the ethnic heterogeneity of the groups in the considered cohorts, and therefore it is necessary to continue epidemiological studies with a large sample size in specific geographic areas.

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The authors declare that there are no conflicts of interest present.