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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2020-5.5.8</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-2441</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕВРОЛОГИЯ И НЕЙРОХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROLOGY AND NEUROSURGERY</subject></subj-group></article-categories><title-group><article-title>Черепно-мозговая травма и нейровоспаление: обзор основных биомаркеров</article-title><trans-title-group xml:lang="en"><trans-title>Traumatic Brain Injury and Neuroinflammation: Review of the Main Biomarkers</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0086-1201</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зудова</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zudova</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка</p><p>620002, г. Екатеринбург, ул. Мира, 19, Россия</p><p>620049, г. Екатеринбург, ул. Первомайская, 106, Россия</p></bio><bio xml:lang="en"><p>ul. Mira 19, Yekaterinburg 620002, Russian Federation</p><p> </p><p>ul. Pervomayskaya 106, 620046, Yekaterinburg Russia, Russian Federation</p></bio><email xlink:type="simple">tina.zudova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9850-9387</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сухоросова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhorosova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка</p><p>620002, г. Екатеринбург, ул. Мира, 19, Россия</p><p>620049, г. Екатеринбург, ул. Первомайская, 106, Россия</p></bio><bio xml:lang="en"><p>ul. Mira 19, Yekaterinburg 620002, Russian Federation ul. Pervomayskaya 106, 620046, Yekaterinburg Russia, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4900-5019</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соломатина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solomatina</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>620002, г. Екатеринбург, ул. Мира, 19, Россия</p><p>620049, г. Екатеринбург, ул. Первомайская, 106, Россия</p></bio><bio xml:lang="en"><p>ul. Mira 19, Yekaterinburg 620002, Russian Federation ul. Pervomayskaya 106, 620046, Yekaterinburg Russia, Russian Federation</p></bio><email xlink:type="simple">slv10@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Уральский федеральный университет имени первого Президента России Б.Н. Ельцина», Институт естественных наук и математики;&#13;
ФГБУН Институт иммунологии и физиологии Уральского отделения Российской академии наук</institution></aff><aff xml:lang="en"><institution>Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia B.N. Yeltsin;&#13;
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>07</day><month>11</month><year>2020</year></pub-date><volume>5</volume><issue>5</issue><fpage>60</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зудова А.И., Сухоросова А.Г., Соломатина Л.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Зудова А.И., Сухоросова А.Г., Соломатина Л.В.</copyright-holder><copyright-holder xml:lang="en">Zudova A.I., Sukhorosova A.G., Solomatina L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/2441">https://www.actabiomedica.ru/jour/article/view/2441</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>черепно-мозговая травма</kwd><kwd>биомаркеры</kwd><kwd>нейровоспаление</kwd></kwd-group><kwd-group xml:lang="en"><kwd>brain injuries</kwd><kwd>biomarkers</kwd><kwd>neuroinflammation</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках госзадания ИИФ УрО РАН (регистрационный номер НИОКТР № АААА-А18- 118020590108-7).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Menon DK, Schwab K, Wright DW, Maas AI, et al. Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil. 2010; 91(11): 1637-1640. doi: 10.1016/j.apmr.2010.05.017</mixed-citation><mixed-citation xml:lang="en">Menon DK, Schwab K, Wright DW, Maas AI, et al. Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil. 2010; 91(11): 1637-1640. doi: 10.1016/j.apmr.2010.05.017</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Yilmaz C, Karali K, Fodelianaki G, Gravanis A, Chavakis T, Charalampopoulos I, et al. Neurosteroids as regulators of neuroinflammation. Front Neuroendocrinol. 2019; 55: 100788. doi: 10.1016/j.yfrne.2019.100788</mixed-citation><mixed-citation xml:lang="en">Yilmaz C, Karali K, Fodelianaki G, Gravanis A, Chavakis T, Charalampopoulos I, et al. Neurosteroids as regulators of neuroinflammation. Front Neuroendocrinol. 2019; 55: 100788. doi: 10.1016/j.yfrne.2019.100788</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Министерство здравоохранения Российской Федерации. Социально-значимые заболевания населения России в 2018 году (статистические материалы). М.; 2019.</mixed-citation><mixed-citation xml:lang="en">Ministry of Health of the Russian Federation. Socially significant diseases of the Russian population in 2018 (statistical materials). M.; 2019. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Лихтерман Л.Б. Классификация черепно-мозговой травмы. Часть II. Современные принципы классификации ЧМТ. Судебная медицина. 2015; 1(3): 37-48.</mixed-citation><mixed-citation xml:lang="en">Lichterman L.B. Classification of cranial trauma. Sudebnaya meditsina. 2015; 1(3): 37-48. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Saatman KE, Duhaime AC, Bullock R, Maas AIR, Valadka A, Manley GT, et al. Classification of traumatic brain injury for targeted therapies. J Neurotrauma. 2008; 25(7): 719-738. doi: 10.1089/neu.2008.0586</mixed-citation><mixed-citation xml:lang="en">Saatman KE, Duhaime AC, Bullock R, Maas AIR, Valadka A, Manley GT, et al. Classification of traumatic brain injury for targeted therapies. J Neurotrauma. 2008; 25(7): 719-738. doi: 10.1089/neu.2008.0586</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Schimmel SJ, Acosta S, Lozano D. Neuroinflammation in traumatic brain injury: A chronic response to an acute injury. Brain Circ. 2017; 3(3): 135-142. doi: 10.4103/bc.bc_18_17</mixed-citation><mixed-citation xml:lang="en">Schimmel SJ, Acosta S, Lozano D. Neuroinflammation intraumatic brain injury: A chronic response to an acute injury. Brain Circ. 2017; 3(3): 135-142. doi: 10.4103/bc.bc_18_17</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ladak AA, Enam SA, Ibrahim MT. A Review of the molecular mechanisms of traumatic brain injury. World Neurosurg. 2019; 131: 126-132. doi: 10.1016/j.wneu.2019.07.039</mixed-citation><mixed-citation xml:lang="en">Ladak AA, Enam SA, Ibrahim MT. A Review of the molecular mechanisms of traumatic brain injury. World Neurosurg. 2019; 131: 126-132. doi: 10.1016/j.wneu.2019.07.039</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sahel DK, Kaira M, Raj K, Sharma S, Singh S. Mitochondrial dysfunctioning and neuroinflammation: recent highlights on the possible mechanisms involved in traumatic brain injury. Neurosci Lett. 2019; 710: 134347. doi: 10.1016/j.neulet.2019.134347</mixed-citation><mixed-citation xml:lang="en">Sahel DK, Kaira M, Raj K, Sharma S, Singh S. Mitochondrial dysfunctioning and neuroinflammation: recent highlights on the possible mechanisms involved in traumatic brain injury. Neurosci Lett. 2019; 710: 134347. doi: 10.1016/j.neulet.2019.134347</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Nasr IW, Chun Y, Kannan S. Neuroimmune responses in the developing brain following traumatic brain injury. Exp Neurol. 2019; 320: 112957. doi: 10.1016/j.expneurol.2019.112957</mixed-citation><mixed-citation xml:lang="en">Nasr IW, Chun Y, Kannan S. Neuroimmune responses in the developing brain following traumatic brain injury. Exp Neurol. 2019; 320: 112957. doi: 10.1016/j.expneurol.2019.112957</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Needham EJ, Helmy A, Zanier ER, Jones JL, Coles AJ, Menon DK. The immunological response to traumatic brain injury. J Neuroimmunol. 2019; 332: 112-125. doi: 10.1016/j.jneuroim.2019.04.005</mixed-citation><mixed-citation xml:lang="en">Needham EJ, Helmy A, Zanier ER, Jones JL, Coles AJ, Menon DK. The immunological response to traumatic brain injury. J Neuroimmunol. 2019; 332: 112-125. doi: 10.1016/j.jneuroim.2019.04.005</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Pearn ML, Niesman IR, Egawa J, Sawada A, AlmenarQueralt A, Shah SB, et al. Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics. Cell Mol Neurobiol. 2017; 37(4): 571-585. doi: 10.1007/s10571-016-0400-1</mixed-citation><mixed-citation xml:lang="en">Pearn ML, Niesman IR, Egawa J, Sawada A, AlmenarQueralt A, Shah SB, et al. Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics. Cell Mol Neurobiol. 2017; 37(4): 571-585. doi: 10.1007/s10571-016-0400-1</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Russo MV, McGavern DB. Inflammatory neuroprotection following traumatic brain injury. Science. 2016; 353(6301): 783- 755. doi: 10.1126/science.aaf6260</mixed-citation><mixed-citation xml:lang="en">Russo MV, McGavern DB. Inflammatory neuroprotection following traumatic brain injury. Science. 2016; 353(6301): 783-755. doi: 10.1126/science.aaf6260</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dinet V, Petry KG, Badaut J. Brain-immune interactions and neuroinflammation after traumatic brain injury. Front Neurosci. 2019; 13: 1178. doi: 10.3389/fnins.2019.01178</mixed-citation><mixed-citation xml:lang="en">Dinet V, Petry KG, Badaut J. Brain-immune interactions and neuroinflammation after traumatic brain injury. Front Neurosci. 2019; 13: 1178. doi: 10.3389/fnins.2019.01178</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Casault C, Al Sultan AS, Banoei M, Couillard P, Kramer A, Winston BW. Cytokine responses in severe traumatic brain injury: where there is smoke, is there fire? Neurocrit Care. 2019; 30(1): 22-32. doi: 10.1007/s12028-018-0522-z</mixed-citation><mixed-citation xml:lang="en">Casault C, Al Sultan AS, Banoei M, Couillard P, Kramer A, Winston BW. Cytokine responses in severe traumatic brain injury: where there is smoke, is there fire? Neurocrit Care. 2019; 30(1): 22-32. doi: 10.1007/s12028-018-0522-z</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rodney T, Osier N, Gill J. Pro- and anti-inflammatory biomarkers and traumatic brain injury outcomes: A review. Cytokine. 2018; 110: 248-256. doi: 10.1016/j.cyto.2018.01.012</mixed-citation><mixed-citation xml:lang="en">Rodney T, Osier N, Gill J. Pro- and anti-inflammatory biomarkers and traumatic brain injury outcomes: A review. Cytokine. 2018; 110: 248-256. doi: 10.1016/j.cyto.2018.01.012</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bogoslovsky T, Gill J, Jeromin A, Davis C, Diaz-Arrastia R. Fluid biomarkers of traumatic brain injury and intended context of use. Diagnostics (Basel). 2016; 6(4): 37. doi: 10.3390/diagnostics6040037</mixed-citation><mixed-citation xml:lang="en">Bogoslovsky T, Gill J, Jeromin A, Davis C, Diaz-Arrastia R. Fluid biomarkers of traumatic brain injury and intended context of use. Diagnostics (Basel). 2016; 6(4): 37. doi: 10.3390/diagnostics6040037</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yang DB, Yu WH, Dong XQ, Zhang ZY, Du Q, Zhu Q, et al. Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury. Clin Chim Acta. 2017; 469: 99-104. doi: 10.1016/j.cca.2017.03.030</mixed-citation><mixed-citation xml:lang="en">Yang DB, Yu WH, Dong XQ, Zhang ZY, Du Q, Zhu Q, et al. Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury. Clin Chim Acta. 2017; 469: 99-104. doi: 10.1016/j.cca.2017.03.030</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Feng MJ, Ning W Bin, Wang W, Lv ZH, Liu XB, Zhu Y, et al. Serum S100A12 as a prognostic biomarker of severe traumatic brain injury. Clin Chim Acta. 2018; 480: 84-91. doi: 10.1016/j.cca.2018.01.044</mixed-citation><mixed-citation xml:lang="en">Feng MJ, Ning W Bin, Wang W, Lv ZH, Liu XB, Zhu Y, et al. Serum S100A12 as a prognostic biomarker of severe traumatic brain injury. Clin Chim Acta. 2018; 480: 84-91. doi: 10.1016/j.cca.2018.01.044</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Di Battista AP, Rhind SG, Hutchison MG, Hassan S, Shiu MY, Inaba K, et al. Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury. J Neuroinflammation. 2016; 13: 40. doi: 10.1186/s12974-016-0500-3</mixed-citation><mixed-citation xml:lang="en">Di Battista AP, Rhind SG, Hutchison MG, Hassan S, Shiu MY, Inaba K, et al. Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury. J Neuroinflammation. 2016; 13: 40. doi: 10.1186/s12974-016-0500-3</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lagerstedt L, Egea-Guerrero JJ, Rodríguez-Rodríguez A, Bustamante A, Montaner J, El Rahal A, et al. Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury. PLoS One. 2018; 13(2): e0193278. doi: 10.1371/journal.pone.0193278</mixed-citation><mixed-citation xml:lang="en">Lagerstedt L, Egea-Guerrero JJ, Rodríguez-Rodríguez A, Bustamante A, Montaner J, El Rahal A, et al. Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury. PLoS One. 2018; 13(2): e0193278. doi: 10.1371/journal.pone.0193278</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Banoei MM, Casault C, Metwaly SM, Winston BW. Metabolomics and biomarker discovery in traumatic brain injury. J Neurotrauma. 2018; 35(16): 1831-1848. doi: 10.1089/neu.2017.5326</mixed-citation><mixed-citation xml:lang="en">Banoei MM, Casault C, Metwaly SM, Winston BW. Metabolomics and biomarker discovery in traumatic brain injury. J Neurotrauma. 2018; 35(16): 1831-1848. doi: 10.1089/neu.2017.5326</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Anada RP, Wong KT, Jayapalan JJ, Hashim OH, Ganesan D. Panel of serum protein biomarkers to grade the severity of traumatic brain injury. Electrophoresis. 2018; 39(18): 2308-2315. doi: 10.1002/elps.201700407</mixed-citation><mixed-citation xml:lang="en">Anada RP, Wong KT, Jayapalan JJ, Hashim OH, Ganesan D. Panel of serum protein biomarkers to grade the severity of traumatic brain injury. Electrophoresis. 2018; 39(18): 2308-2315. doi: 10.1002/elps.201700407</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Huie JR, Diaz-Arrastia R, Yue JK, Sorani MD, Puccio AM, Okonkwo DO, et al. Testing a multivariate proteomic panel for traumatic brain injury biomarker discovery: a TRACK-TBI pilot study. J Neurotrauma. 2019; 36(1): 100-110. doi: 10.1089/neu.2017.5449</mixed-citation><mixed-citation xml:lang="en">Huie JR, Diaz-Arrastia R, Yue JK, Sorani MD, Puccio AM, Okonkwo DO, et al. Testing a multivariate proteomic panel for traumatic brain injury biomarker discovery: a TRACK-TBI pilot study. J Neurotrauma. 2019; 36(1): 100-110. doi: 10.1089/neu.2017.5449</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Corrigan F, Mander KA, Leonard AV, Vink R. Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation. J Neuroinflammation. 2016; 13(1): 264. doi: 10.1186/s12974-016-0738-9</mixed-citation><mixed-citation xml:lang="en">Corrigan F, Mander KA, Leonard AV, Vink R. Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation. J Neuroinflammation. 2016; 13(1): 264. doi: 10.1186/s12974-016-0738-9</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Vink R, Gabrielian L, Thornton E. The role of substance P in secondary pathophysiology after traumatic brain injury. Front Neurol. 2017; 8: 304. doi: 10.3389/fneur.2017.00304</mixed-citation><mixed-citation xml:lang="en">Vink R, Gabrielian L, Thornton E. The role of substance P in secondary pathophysiology after traumatic brain injury. Front Neurol. 2017; 8: 304. doi: 10.3389/fneur.2017.00304</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron. 2017; 95(6): 1246‐1265. doi: 10.1016/j.neuron.2017.07.010</mixed-citation><mixed-citation xml:lang="en">Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron. 2017; 95(6): 1246‐1265. doi: 10.1016/j.neuron.2017.07.010</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
