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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2020-5.5.2</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-2434</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИСКУССИОННЫЕ СТАТЬИ, ЛЕКЦИИ, НОВЫЕ ТРЕНДЫ МЕДИЦИНСКОЙ НАУКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISCUSSION PAPERS, LECTURES, NEW TRENDS IN MEDICAL SCIENCE</subject></subj-group></article-categories><title-group><article-title>Происхождение митохондрий и их роль в эволюции жизни и здоровья человека</article-title><trans-title-group xml:lang="en"><trans-title>The Origin of Mitochondria and their Role in the Evolution of Life and Human Health</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8198-7780</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Panov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор биологических наук, старший научный сотрудник лаборатории патофизиологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Timiryaseva str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">alexander.panov55@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7692-9954</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голубенко</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golubenko</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник лаборатории популяционной генетики</p><p>634050, г. Томск, ул. Набережная реки Ушайки, 10, Россия</p></bio><bio xml:lang="en"><p>Naberezhnaya Ushaiki str. 10, Tomsk 634050, Russian Federation</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3255-2013</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Даренская</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Darenskaya</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор биологических наук, ведущий научный сотрудник лаборатории патофизиологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Timiryaseva str. 16, Irkutsk 664003, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2124-6328</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колесников</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolesnikov</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>академик РАН, главный научный сотрудник</p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Timiryaseva str. 16, Irkutsk 664003, Russian Federation </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»</institution></aff><aff xml:lang="en"><institution>Scientific Centre for the Family Health and Human Reproduction Problems</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт медицинской генетики ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»</institution></aff><aff xml:lang="en"><institution>Research Institute of Medical Genetics, Tomsk National Research Medical  Center of the Russian Academy of Sciences</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>05</day><month>11</month><year>2020</year></pub-date><volume>5</volume><issue>5</issue><fpage>12</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Панов А.В., Голубенко М.В., Даренская М.А., Колесников С.И., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Панов А.В., Голубенко М.В., Даренская М.А., Колесников С.И.</copyright-holder><copyright-holder xml:lang="en">Panov A.V., Golubenko M.V., Darenskaya M.A., Kolesnikov S.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/2434">https://www.actabiomedica.ru/jour/article/view/2434</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>митохондрии</kwd><kwd>старение</kwd><kwd>эволюция</kwd><kwd>митохондриальная ДНК</kwd><kwd>«материнское проклятие»</kwd><kwd>гендерные различия</kwd><kwd>метаболизм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mitochondria</kwd><kwd>aging</kwd><kwd>evolution</kwd><kwd>mitochondrial DNA</kwd><kwd>mother’s curse</kwd><kwd>gender differences</kwd><kwd>metabolism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace DC. Structure and evolution of organelle genomes. Microbiol Rev. 1982; 46(2): 208-240.</mixed-citation><mixed-citation xml:lang="en">Wallace DC. Structure and evolution of organelle genomes. Microbiol Rev. 1982; 46(2): 208-240.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace DC. Diseases of the mitochondrial DNA. Annu Rev Biochem. 1992; 61: 1175-1212. doi: 10.1146/annurev.bi.61.070192.005523</mixed-citation><mixed-citation xml:lang="en">Wallace DC. Diseases of the mitochondrial DNA. Annu Rev Biochem. 1992; 61: 1175-1212. doi: 10.1146/annurev.bi.61.070192.005523</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005; 39: 359-407. doi: 10.1146/annurev.genet.39.110304.095751</mixed-citation><mixed-citation xml:lang="en">Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005; 39: 359-407. doi: 10.1146/annurev.genet.39.110304.095751</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace DC. Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine. Annu Rev Biochem. 2007; 76: 781-821. doi: 10.1146/annurev.biochem.76.081205.150955</mixed-citation><mixed-citation xml:lang="en">Wallace DC. Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine. Annu Rev Biochem. 2007; 76: 781-821. doi: 10.1146/annurev.biochem.76.081205.150955</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace DC. Mitochondria as chi. Genetics. 2008; 179(2): 727-735. doi: 10.1534/genetics.104.91769</mixed-citation><mixed-citation xml:lang="en">Wallace DC. Mitochondria as chi. Genetics. 2008; 179(2): 727-735. doi: 10.1534/genetics.104.91769</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace DC, Fan W. Energetics, epigenetics, mitochondrial genetics. Mitochondrion. 2010; 10(1): 12-31. doi: 10.1016/j.mito.2009.09.006</mixed-citation><mixed-citation xml:lang="en">Wallace DC, Fan W. Energetics, epigenetics, mitochondrial genetics. Mitochondrion. 2010; 10(1): 12-31. doi: 10.1016/j.mito.2009.09.006</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hörandl E, Speijer D. How oxygen gave rise to eukaryotic sex. Proc Biol Sci. 2018; 285(1872): 20172706. doi: 10.1098/rspb.2017.2706</mixed-citation><mixed-citation xml:lang="en">Hörandl E, Speijer D. How oxygen gave rise to eukaryotic sex. Proc Biol Sci. 2018; 285(1872): 20172706. doi: 10.1098/rspb.2017.2706</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Gaziev AI, Shaikhaev GO. Nuclear mitochondrial pseudogenes. Molecular Biology. 2010; 44(3): 405-417. doi: 10.1134/S0026893310030027</mixed-citation><mixed-citation xml:lang="en">Gaziev AI, Shaikhaev GO. Nuclear mitochondrial pseudogenes. Molecular Biology. 2010; 44(3): 405-417. doi: 10.1134/S0026893310030027</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Behe MJ. Darwin’s Black Box. New York: Free Press; 1996.</mixed-citation><mixed-citation xml:lang="en">Behe MJ. Darwin’s Black Box. New York: Free Press; 1996.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Thompson В, Harrub B. Molecular evidence of human origins – [Part II]. Reason and Revelation. 2005; 25(5): 33-39.</mixed-citation><mixed-citation xml:lang="en">Thompson В, Harrub B. Molecular evidence of human origins – [Part II]. Reason and Revelation. 2005; 25(5): 33-39.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sagan L. On the origin of mitosing cells. J Theor Biol. 1967; 14(3): 255-274. doi: 10.1016/0022-5193(67)90079-3</mixed-citation><mixed-citation xml:lang="en">Sagan L. On the origin of mitosing cells. J Theor Biol. 1967; 14(3): 255-274. doi: 10.1016/0022-5193(67)90079-3</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lang BF, Gray MW, Burger G. Mitochondrial genome revolution and the origin of eukaryotes. Annu Rev Genet. 1999; 33: 351-397. doi: 10.1146/annurev.genet.33.1.351</mixed-citation><mixed-citation xml:lang="en">Lang BF, Gray MW, Burger G. Mitochondrial genome revolution and the origin of eukaryotes. Annu Rev Genet. 1999; 33: 351-397. doi: 10.1146/annurev.genet.33.1.351</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lang BF, Burger B, O’Kelly CJ, Cedergren R, Golding GB, Lemieux C, et al. An ancestral mitochondrial DNA resembling a eubacterial genome in miniature. Nature. 1997; 387(6632): 493-497. doi: 10.1038/387493a0</mixed-citation><mixed-citation xml:lang="en">Lang BF, Burger B, O’Kelly CJ, Cedergren R, Golding GB, Lemieux C, et al. An ancestral mitochondrial DNA resembling a eubacterial genome in miniature. Nature. 1997; 387(6632): 493-497. doi: 10.1038/387493a0</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gray MW, Burger G, Lang BF. Mitochondrial evolution. Science. 1999; 283(5407): 1476-1481. doi: 10.1126/science.283.5407.1476</mixed-citation><mixed-citation xml:lang="en">Gray MW, Burger G, Lang BF. Mitochondrial evolution. Science. 1999; 283(5407): 1476-1481. doi: 10.1126/science.283.5407.1476</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gregersen N, Hansen J, Palmfeldt J. Mitochondrial proteomics – a tool for the study of metabolic disorders. J Inherit Metab Dis. 2012; 35(4): 715-726. doi: 10.1007/s10545-012-9480-3</mixed-citation><mixed-citation xml:lang="en">Gregersen N, Hansen J, Palmfeldt J. Mitochondrial proteomics – a tool for the study of metabolic disorders. J Inherit Metab Dis. 2012; 35(4): 715-726. doi: 10.1007/s10545-012-9480-3</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Price DC, Chan CX, Su Yoon H, Yang EC, Qiu H, Weber AP, et al. Cyanophora paradoxa genome elucidates origin of photosynthesis in algae and plants. Science. 2012; 335(6070): 843-847. doi: 10.1126/science.1213561</mixed-citation><mixed-citation xml:lang="en">Price DC, Chan CX, Su Yoon H, Yang EC, Qiu H, Weber AP, et al. Cyanophora paradoxa genome elucidates origin of photosynthesis in algae and plants. Science. 2012; 335(6070): 843-847. doi: 10.1126/science.1213561</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Archibald JM. The puzzle of plastid evolution. Curr Biol. 2009; 19(2): R81-R88. doi: 10.1016/j.cub.2008.11.067</mixed-citation><mixed-citation xml:lang="en">Archibald JM. The puzzle of plastid evolution. Curr Biol. 2009; 19(2): R81-R88. doi: 10.1016/j.cub.2008.11.067</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">McFadden GI, Van Dooren GG. Evolution: red algal genome affirms a common origin of all plastids. Curr Biol. 2004; 14(13): R514-R516. doi: 10.1016/j.cub.2004.06.041</mixed-citation><mixed-citation xml:lang="en">McFadden GI, Van Dooren GG. Evolution: red algal genome affirms a common origin of all plastids. Curr Biol. 2004; 14(13): R514-R516. doi: 10.1016/j.cub.2004.06.041</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Greiner S, Sobanski J, Bock R. Why are most organelle genomes transmitted maternally? Bioessays. 2015; 37(1): 80-94. doi: 10.1002/bies.201400110</mixed-citation><mixed-citation xml:lang="en">Greiner S, Sobanski J, Bock R. Why are most organelle genomes transmitted maternally? Bioessays. 2015; 37(1): 80-94. doi: 10.1002/bies.201400110</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Christie JR, Beekman M. Uniparental inheritance promotes adaptive evolution in cytoplasmic genomes. Mol Biol Evol. 2017; 34(3): 677-691. doi: 10.1093/molbev/msw266</mixed-citation><mixed-citation xml:lang="en">Christie JR, Beekman M. Uniparental inheritance promotes adaptive evolution in cytoplasmic genomes. Mol Biol Evol. 2017; 34(3): 677-691. doi: 10.1093/molbev/msw266</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, et al. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003; 115(5): 629-640. doi: 10.1016/S0092-8674(03)00926-7</mixed-citation><mixed-citation xml:lang="en">Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, et al. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003; 115(5): 629-640. doi: 10.1016/S0092-8674(03)00926-7</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Woodson JD, Chory J. Coordination of gene expression between organellar and nuclear genomes. Nat Rev Genet. 2008; 9(5): 383-395. doi: 10.1038/nrg2348</mixed-citation><mixed-citation xml:lang="en">Woodson JD, Chory J. Coordination of gene expression between organellar and nuclear genomes. Nat Rev Genet. 2008; 9(5): 383-395. doi: 10.1038/nrg2348</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N. Importing mitochondrial proteins: machineries and mechanisms. Cell. 2009; 138(4): 628-644. doi: 10.1016/j.cell.2009.08.005</mixed-citation><mixed-citation xml:lang="en">Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N. Importing mitochondrial proteins: machineries and mechanisms. Cell. 2009; 138(4): 628-644. doi: 10.1016/j.cell.2009.08.005</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bensasson D, Feldman MW, Petrov DA. Rates of DNA duplication and mitochondrial DNA insertion in the human genome. J Mol Evol. 2003; 57(3): 343-354. doi: 10.1007/s00239-003-2485-7</mixed-citation><mixed-citation xml:lang="en">Bensasson D, Feldman MW, Petrov DA. Rates of DNA duplication and mitochondrial DNA insertion in the human genome. J Mol Evol. 2003; 57(3): 343-354. doi: 10.1007/s00239-003-2485-7</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion. 2016; 30: 105-116. doi: 10.1016/j.mito.2016.07.003</mixed-citation><mixed-citation xml:lang="en">Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion. 2016; 30: 105-116. doi: 10.1016/j.mito.2016.07.003</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kazak L, Reyes A, Holt IJ. Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol. 2012; 13(10): 659-671. doi: 10.1038/nrm3439</mixed-citation><mixed-citation xml:lang="en">Kazak L, Reyes A, Holt IJ. Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol. 2012; 13(10): 659-671. doi: 10.1038/nrm3439</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gilkerson R, Bravo L, Garcia I, Gaytan N, Herrera A, Maldonado A, et al. The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis. Cold Spring Harb Perspect Biol. 2013; 5(5): a011080. doi: 10.1101/cshperspect.a011080</mixed-citation><mixed-citation xml:lang="en">Gilkerson R, Bravo L, Garcia I, Gaytan N, Herrera A, Maldonado A, et al. The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis. Cold Spring Harb Perspect Biol. 2013; 5(5): a011080. doi: 10.1101/cshperspect.a011080</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tarnopolsky MA. Gender differences in substrate metabolism during endurance exercise. Can J Appl Physiol. 2000; 25(4): 312-327. doi: 10.1139/h00-024</mixed-citation><mixed-citation xml:lang="en">Tarnopolsky MA. Gender differences in substrate metabolism during endurance exercise. Can J Appl Physiol. 2000; 25(4): 312-327. doi: 10.1139/h00-024</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Dionne I, Despres JP, Bouchard C, Tremblay A. Gender difference in the effect of body composition on energy metabolism. Int J Obes Relat Metab Disord. 1999; 23(3): 312-319. doi: 10.1038/sj.ijo.0800820</mixed-citation><mixed-citation xml:lang="en">Dionne I, Despres JP, Bouchard C, Tremblay A. Gender difference in the effect of body composition on energy metabolism. Int J Obes Relat Metab Disord. 1999; 23(3): 312-319. doi: 10.1038/sj.ijo.0800820</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Leskanicova A, Chovancova O, Babincak M, Verboova L, Benetinova Z, Macekova D, et al. Sexual dimorphism in energy metabolism of Wistar rats using data analysis. Molecules. 2020; 25(10): 2353. doi: 10.3390/molecules25102353</mixed-citation><mixed-citation xml:lang="en">Leskanicova A, Chovancova O, Babincak M, Verboova L, Benetinova Z, Macekova D, et al. Sexual dimorphism in energy metabolism of Wistar rats using data analysis. Molecules. 2020; 25(10): 2353. doi: 10.3390/molecules25102353</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Giles RE, Blanc H, Cann HM, Wallace DC. Maternal inheritance of human mitochondrial DNA. Proc Natl Acad Sci USA. 1980; 77(11): 6715-6719. doi: 10.1073/pnas.77.11.6715</mixed-citation><mixed-citation xml:lang="en">Giles RE, Blanc H, Cann HM, Wallace DC. Maternal inheritance of human mitochondrial DNA. Proc Natl Acad Sci USA. 1980; 77(11): 6715-6719. doi: 10.1073/pnas.77.11.6715</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Morrow JD, Awad JA, Wu A, Zackert WE, Daniel VC, Roberts LJ. Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo. J Biol Chem. 1996; 271(38): 23185-23190. doi: 10.1074/jbc.271.38.23185</mixed-citation><mixed-citation xml:lang="en">Morrow JD, Awad JA, Wu A, Zackert WE, Daniel VC, Roberts LJ. Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo. J Biol Chem. 1996; 271(38): 23185-23190. doi: 10.1074/jbc.271.38.23185</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts LJ, Montine TJ, Markesbery WR, Tapper AP, Hardy H, Chemtob S, et al. Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem. 1998; 273(22): 13605-13612. doi: 10.1074/jbc.273.22.13605</mixed-citation><mixed-citation xml:lang="en">Roberts LJ, Montine TJ, Markesbery WR, Tapper AP, Hardy H, Chemtob S, et al. Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem. 1998; 273(22): 13605-13612. doi: 10.1074/jbc.273.22.13605</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Panov A. Perhydroxyl radical (HO2•) as inducer of the isoprostane lipid peroxidation in mitochondria. Molecular Biology. 2018; 52(3): 347-359. doi: 10.1134/S0026893318020097</mixed-citation><mixed-citation xml:lang="en">Panov A. Perhydroxyl radical (HO2•) as inducer of the isoprostane lipid peroxidation in mitochondria. Molecular Biology. 2018; 52(3): 347-359. doi: 10.1134/S0026893318020097</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Panov AV, Dikalov SI. Mitochondrial metabolism and the age-associated cardiovascular diseases. EC Cardiology. 2018; 5.11: 750-769.</mixed-citation><mixed-citation xml:lang="en">Panov AV, Dikalov SI. Mitochondrial metabolism and the age-associated cardiovascular diseases. EC Cardiology. 2018; 5.11: 750-769.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Panov AV, Golubenko MV. Human metabolic syndrome as one of the last stages of postembryonic ontogenesis. Understanding human heart diseases at old age. EC Cardiology. 2020; 7.8: 41-47.</mixed-citation><mixed-citation xml:lang="en">Panov AV, Golubenko MV. Human metabolic syndrome as one of the last stages of postembryonic ontogenesis. Understanding human heart diseases at old age. EC Cardiology. 2020; 7.8: 41-47.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Panov AV, Dikalov SI. Cardiolipin, perhydroxyl radicals and lipid peroxidation in mitochondrial dysfunctions and aging. Oxidative Medicine and Cellular Longevity. 2020; 1323028. doi: 10.1155/2020/1323028</mixed-citation><mixed-citation xml:lang="en">Panov AV, Dikalov SI. Cardiolipin, perhydroxyl radicals and lipid peroxidation in mitochondrial dysfunctions and aging. Oxidative Medicine and Cellular Longevity. 2020; 1323028. doi: 10.1155/2020/1323028</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Panov A, Orynbayeva Z. Determination of mitochondrial metabolic phenotype through investigation of the intrinsic inhibition of succinate dehydrogenase. Analytical Biochemistry. 2018; 552: 30-37. doi: 10.1016/j.ab.2017.10.010</mixed-citation><mixed-citation xml:lang="en">Panov A, Orynbayeva Z. Determination of mitochondrial metabolic phenotype through investigation of the intrinsic inhibition of succinate dehydrogenase. Analytical Biochemistry. 2018; 552: 30-37. doi: 10.1016/j.ab.2017.10.010</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3): 298-300. doi: 10.1196/annals.1354.003</mixed-citation><mixed-citation xml:lang="en">Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3): 298-300. doi: 10.1196/annals.1354.003</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Harman D. Free radical theory of aging: Consequences of mitochondrial aging. Age.1983; 6: 86-94. doi: 10.1007/BF02432509</mixed-citation><mixed-citation xml:lang="en">Harman D. Free radical theory of aging: Consequences of mitochondrial aging. Age.1983; 6: 86-94. doi: 10.1007/BF02432509</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998; 78(2): 547-581. doi: 10.1152/physrev.1998.78.2.547</mixed-citation><mixed-citation xml:lang="en">Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998; 78(2): 547-581. doi: 10.1152/physrev.1998.78.2.547</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kukat C, Wurm CA, Spahr H, Falkenberg M, Larsson NG, Jakobs S. Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA. Proc Natl Acad Sci USA. 2011; 108(33): 13534-13539. doi: 10.1073/pnas.1109263108</mixed-citation><mixed-citation xml:lang="en">Kukat C, Wurm CA, Spahr H, Falkenberg M, Larsson NG, Jakobs S. Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA. Proc Natl Acad Sci USA. 2011; 108(33): 13534-13539. doi: 10.1073/pnas.1109263108</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson AP, Xuemei L, William R, Yin YW. Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity. Nucleic Acids Research. 2020; 48(2): 817-829. doi: 10.1093/nar/gkz1018</mixed-citation><mixed-citation xml:lang="en">Anderson AP, Xuemei L, William R, Yin YW. Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity. Nucleic Acids Research. 2020; 48(2): 817-829. doi: 10.1093/nar/gkz1018</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA. 2005; 102(50): 17993-17998. doi: 10.1073/pnas.0508886102</mixed-citation><mixed-citation xml:lang="en">Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA. 2005; 102(50): 17993-17998. doi: 10.1073/pnas.0508886102</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Panov AV. A new look at the causes of heart failure at old age. EC Cardiology. 2020; 7.2: 01-07.</mixed-citation><mixed-citation xml:lang="en">Panov AV. A new look at the causes of heart failure at old age. EC Cardiology. 2020; 7.2: 01-07.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Neckelmann N, Li K, Wade RP, Shuster R, Wallace DC. cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes. Proc Natl Acad Sci USA. 1987; 84(21): 7580-7584. doi: 10.1073/pnas.84.21.7580</mixed-citation><mixed-citation xml:lang="en">Neckelmann N, Li K, Wade RP, Shuster R, Wallace DC. cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes. Proc Natl Acad Sci USA. 1987; 84(21): 7580-7584. doi: 10.1073/pnas.84.21.7580</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Szczepanowska K, Trifunovic A. Origins of mtDNA mutations in ageing. Essays in Biochemistry. 2017; 61.3: 325-337. doi: 10.1042/EBC20160090</mixed-citation><mixed-citation xml:lang="en">Szczepanowska K, Trifunovic A. Origins of mtDNA mutations in ageing. Essays in Biochemistry. 2017; 61.3: 325-337. doi: 10.1042/EBC20160090</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Back JW, Sanz MA, De Jong L, De Koning LJ, Nijtmans GL, De Koster CG, et al. A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry. Protein Sci. 2002; 11(10): 2471-2478. doi: 10.1110/ps.0212602</mixed-citation><mixed-citation xml:lang="en">Back JW, Sanz MA, De Jong L, De Koning LJ, Nijtmans GL, De Koster CG, et al. A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry. Protein Sci. 2002; 11(10): 2471-2478. doi: 10.1110/ps.0212602</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Gemmell NJ, Metcalf VJ, Allendorf FW. Mother’s curse: the effect of mtDNA on individual fitness and population viability. Trends Ecol Evol. 2004; 19: 238-244. doi: 10.1016/j.tree.2004.02.002</mixed-citation><mixed-citation xml:lang="en">Gemmell NJ, Metcalf VJ, Allendorf FW. Mother’s curse: the effect of mtDNA on individual fitness and population viability. Trends Ecol Evol. 2004; 19: 238-244. doi: 10.1016/j.tree.2004.02.002</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Muller M, Martin W. The genome of Rickettsia prowazekii and some thoughts on the origin of mitochondria and hydrogenosomes. Bioessays. 1999; 21(5): 377-381. doi: 10.1002/(SICI)1521-1878(199905)21:5&lt;377::AID-BIES4&gt;3.0.CO;2-W</mixed-citation><mixed-citation xml:lang="en">Muller M, Martin W. The genome of Rickettsia prowazekii and some thoughts on the origin of mitochondria and hydrogenosomes. Bioessays. 1999; 21(5): 377-381. doi: 10.1002/(SICI)1521-1878(199905)21:5&lt;377::AID-BIES4&gt;3.0.CO;2-W</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Hoekstra RF. Evolutionary biology: why sex is good. Nature. 2005; 434(7033): 571-573. doi: 10.1038/434571a</mixed-citation><mixed-citation xml:lang="en">Hoekstra RF. Evolutionary biology: why sex is good. Nature. 2005; 434(7033): 571-573. doi: 10.1038/434571a</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Hoekstra RF. Evolutionary origin and consequences of uniparental mitochondrial inheritance. Hum Reprod. 2000; 15(Suppl 2): 102-111. doi: 10.1093/humrep/15.suppl_2.102</mixed-citation><mixed-citation xml:lang="en">Hoekstra RF. Evolutionary origin and consequences of uniparental mitochondrial inheritance. Hum Reprod. 2000; 15(Suppl 2): 102-111. doi: 10.1093/humrep/15.suppl_2.102</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Muller HJ. The relation of recombination to mutational advance. Mutat Res. 1964; 1(1): 2-9. doi: 10.1016/0027-5107(64)90047-8</mixed-citation><mixed-citation xml:lang="en">Muller HJ. The relation of recombination to mutational advance. Mutat Res. 1964; 1(1): 2-9. doi: 10.1016/0027-5107(64)90047-8</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Jenuth JP, Peterson AC, Fu K, Shoubridge EA. Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nat Genet. 1996; 14(2): 146-151. doi: 10.1038/ng1096-146</mixed-citation><mixed-citation xml:lang="en">Jenuth JP, Peterson AC, Fu K, Shoubridge EA. Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nat Genet. 1996; 14(2): 146-151. doi: 10.1038/ng1096-146</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Bergstrom CT, Pritchard J. Germline bottlenecks and the evolutionary maintenance of mitochondrial genomes. Genetics. 1998; 149(4): 2135-2146.</mixed-citation><mixed-citation xml:lang="en">Bergstrom CT, Pritchard J. Germline bottlenecks and the evolutionary maintenance of mitochondrial genomes. Genetics. 1998; 149(4): 2135-2146.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Michaels GS, Hauswirth WW, Laipis PJ. Mitochondrial DNA copy number in bovine oocytes and somatic cells. Dev Biol. 1982; 94(1): 246-251. doi: 10.1016/0012-1606(82)90088-4</mixed-citation><mixed-citation xml:lang="en">Michaels GS, Hauswirth WW, Laipis PJ. Mitochondrial DNA copy number in bovine oocytes and somatic cells. Dev Biol. 1982; 94(1): 246-251. doi: 10.1016/0012-1606(82)90088-4</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Reynier P, May-Panloup P, Chretien MF, Morgan CJ, Jean M, Savagner F, et al. Mitochondrial DNA content affects the fertilizability of human oocytes. Mol Hum Reprod. 2001; 7(5): 425-429. doi: 10.1093/molehr/7.5.425</mixed-citation><mixed-citation xml:lang="en">Reynier P, May-Panloup P, Chretien MF, Morgan CJ, Jean M, Savagner F, et al. Mitochondrial DNA content affects the fertilizability of human oocytes. Mol Hum Reprod. 2001; 7(5): 425-429. doi: 10.1093/molehr/7.5.425</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Sutovsky P, Moreno RD, Ramalho-Santos J, Dominko T, Simerly C, Schatten G. Ubiquitin tag for sperm mitochondria. Nature. 1999; 402(6760): 371-372. doi: 10.1038/46466</mixed-citation><mixed-citation xml:lang="en">Sutovsky P, Moreno RD, Ramalho-Santos J, Dominko T, Simerly C, Schatten G. Ubiquitin tag for sperm mitochondria. Nature. 1999; 402(6760): 371-372. doi: 10.1038/46466</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Thompson WE, Ramalho-Santos J, Sutovsky P. Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol Reprod. 2003; 69(1): 254-260. doi: 10.1095/biolreprod.102.010975</mixed-citation><mixed-citation xml:lang="en">Thompson WE, Ramalho-Santos J, Sutovsky P. Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol Reprod. 2003; 69(1): 254-260. doi: 10.1095/biolreprod.102.010975</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Artal-Sanz M, Tavernarakis N. Prohibitin and mitochondrial biology. Trends Endocrinol Metab. 2009; 20(8): 394-401. doi: 10.1016/j.tem.2009.04.004</mixed-citation><mixed-citation xml:lang="en">Artal-Sanz M, Tavernarakis N. Prohibitin and mitochondrial biology. Trends Endocrinol Metab. 2009; 20(8): 394-401. doi: 10.1016/j.tem.2009.04.004</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Frank SA, Hurst LD. Mitochondria and male disease. Nature. 1996; 383: 224. doi: 10.1038/383224a0</mixed-citation><mixed-citation xml:lang="en">Frank SA, Hurst LD. Mitochondria and male disease. Nature. 1996; 383: 224. doi: 10.1038/383224a0</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Ruiz-Pesini E, Lapena AC, Diez-Sanchez C, Perez-Martos A, Montoya J, Alvarez E, et al. Human mtDNA haplogroups associated with high or reduced spermatozoa motility. Am J Hum Genet. 2000; 67(3): 682-696. doi: 10.1086/303040</mixed-citation><mixed-citation xml:lang="en">Ruiz-Pesini E, Lapena AC, Diez-Sanchez C, Perez-Martos A, Montoya J, Alvarez E, et al. Human mtDNA haplogroups associated with high or reduced spermatozoa motility. Am J Hum Genet. 2000; 67(3): 682-696. doi: 10.1086/303040</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Gemmell NJ, Allendorf FW. Mitochondrial mutations may decrease population viability. Trends Ecol Evol. 2001; 16: 115-117. doi: 10.1016/S0169-5347(00)02087-5</mixed-citation><mixed-citation xml:lang="en">Gemmell NJ, Allendorf FW. Mitochondrial mutations may decrease population viability. Trends Ecol Evol. 2001; 16: 115-117. doi: 10.1016/S0169-5347(00)02087-5</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Rand DM. The units of selection on mitochondrial DNA. Annu Rev Ecol Syst. 2001; 32: 415-449. doi: 10.1146/annurev.ecolsys.32.081501.114109</mixed-citation><mixed-citation xml:lang="en">Rand DM. The units of selection on mitochondrial DNA. Annu Rev Ecol Syst. 2001; 32: 415-449. doi: 10.1146/annurev.ecolsys.32.081501.114109</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Lynch M, Blanchard JL. Deleterious mutation accumulation in organelle genomes. Genetica. 1998; 102-103(1-6): 29-39. doi: 10.1023/A:1017022522486</mixed-citation><mixed-citation xml:lang="en">Lynch M, Blanchard JL. Deleterious mutation accumulation in organelle genomes. Genetica. 1998; 102-103(1-6): 29-39. doi: 10.1023/A:1017022522486</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Lewontin RC. The units of selection. Annu Rev Ecol Syst. 1970; 1: 1-18. doi: 10.1146/annurev.es.01.110170.000245</mixed-citation><mixed-citation xml:lang="en">Lewontin RC. The units of selection. Annu Rev Ecol Syst. 1970; 1: 1-18. doi: 10.1146/annurev.es.01.110170.000245</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Reid RA. Selfish DNA in “petite” mutants. Nature. 1980; 285: 620. doi: 10.1038/285620b0</mixed-citation><mixed-citation xml:lang="en">Reid RA. Selfish DNA in “petite” mutants. Nature. 1980; 285: 620. doi: 10.1038/285620b0</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace DC. Mitochondrial diseases in man and mouse. Science. 1999; 283: 1482-1488. doi: 10.1126/science.283.5407.1482</mixed-citation><mixed-citation xml:lang="en">Wallace DC. Mitochondrial diseases in man and mouse. Science. 1999; 283: 1482-1488. doi: 10.1126/science.283.5407.1482</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Craig DM. Group selection versus individual selection: an experimental analysis. Evolution. 1982; 36(2): 271-282. doi: 10.2307/2408045</mixed-citation><mixed-citation xml:lang="en">Craig DM. Group selection versus individual selection: an experimental analysis. Evolution. 1982; 36(2): 271-282. doi: 10.2307/2408045</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Goodnight CJ, Stevens L. Experimental studies of group selection: what do they tell us about group selection in nature? Am Nat. 1997; 150(1): S59-S79. doi: 10.1086/286050</mixed-citation><mixed-citation xml:lang="en">Goodnight CJ, Stevens L. Experimental studies of group selection: what do they tell us about group selection in nature? Am Nat. 1997; 150(1): S59-S79. doi: 10.1086/286050</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Swenson W, Wilson DS, Elias R. Artificial ecosystem selection. Proc Natl Acad Sci USA. 2000; 97(17): 9110-9114. doi: 10.1073/pnas.150237597</mixed-citation><mixed-citation xml:lang="en">Swenson W, Wilson DS, Elias R. Artificial ecosystem selection. Proc Natl Acad Sci USA. 2000; 97(17): 9110-9114. doi: 10.1073/pnas.150237597</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Goodnight CJ. Heritability at the ecosystem level. Proc Natl Acad Sci USA. 2000; 97(17): 9365-9466. doi: 10.1073/pnas.97.17.9365</mixed-citation><mixed-citation xml:lang="en">Goodnight CJ. Heritability at the ecosystem level. Proc Natl Acad Sci USA. 2000; 97(17): 9365-9466. doi: 10.1073/pnas.97.17.9365</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic treatments for coronavirus disease 2019 (COVID-19). JAMA. 2020; 323(18): 1824-1836. doi: 10.1001/jama.2020.6019</mixed-citation><mixed-citation xml:lang="en">Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic treatments for coronavirus disease 2019 (COVID-19). JAMA. 2020; 323(18): 1824-1836. doi: 10.1001/jama.2020.6019</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Blinov VM, Zverev VV, Krasnov GS, Filatov FP, Shargunov AV. Viral component of the human genome. Molecular Biology. 2017; 51, 205-215. doi: 10.1134/S0026893317020066</mixed-citation><mixed-citation xml:lang="en">Blinov VM, Zverev VV, Krasnov GS, Filatov FP, Shargunov AV. Viral component of the human genome. Molecular Biology. 2017; 51, 205-215. doi: 10.1134/S0026893317020066</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Brown JA, Sammy MJ, Ballinger SW. An evolutionary, or “mitocentric” perspective on cellular function and disease. Redox Biol. 2020; 36: 101568. doi: 10.1016/j.redox.2020.101568</mixed-citation><mixed-citation xml:lang="en">Brown JA, Sammy MJ, Ballinger SW. An evolutionary, or “mitocentric” perspective on cellular function and disease. Redox Biol. 2020; 36: 101568. doi: 10.1016/j.redox.2020.101568</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Mereschkowsky C. Über Natur und Ursprung der Chromatophoren imPflanzenreiche. Biol Centralbl. 1905; 25: 593-604.</mixed-citation><mixed-citation xml:lang="en">Mereschkowsky C. Über Natur und Ursprung der Chromatophoren imPflanzenreiche. Biol Centralbl. 1905; 25: 593-604.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Portier P. Les Symbiotes. Paris: Masson; 1918.</mixed-citation><mixed-citation xml:lang="en">Portier P. Les Symbiotes. Paris: Masson; 1918.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Walli IE. Symbionticism and the origin of species. Baltimore: Williams &amp; Wilkins Company; 1927.</mixed-citation><mixed-citation xml:lang="en">Walli IE. Symbionticism and the origin of species. Baltimore: Williams &amp; Wilkins Company; 1927.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Sagan L. On the origin of mitosing cells. J Theor Biol. 1967; 14(3): 255-274. doi: 10.1016/0022-5193(67)90079-3</mixed-citation><mixed-citation xml:lang="en">Sagan L. On the origin of mitosing cells. J Theor Biol. 1967; 14(3): 255-274. doi: 10.1016/0022-5193(67)90079-3</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Lake JA. Lynn Margulis (1938-2011). Nature. 2011; 480(7378): 458. doi: 10.1038/480458a</mixed-citation><mixed-citation xml:lang="en">Lake JA. Lynn Margulis (1938-2011). Nature. 2011; 480(7378): 458. doi: 10.1038/480458a</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz RM, Dayhoff MO. Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts. Science. 1978; 199(4327): 395-403. doi: 10.1126/science.202030</mixed-citation><mixed-citation xml:lang="en">Schwartz RM, Dayhoff MO. Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts. Science. 1978; 199(4327): 395-403. doi: 10.1126/science.202030</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
