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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2019-4.6.11</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-2200</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТРАВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TRAUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Лечение контрактуры Дюпюитрена на современном этапе (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Treatment of Dupuytren's Contracture at the Present Stage (Literature Review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2749-2768</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бутаев</surname><given-names>Ч. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Butaev</surname><given-names>Ch. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бутаев ЧингизЗахирович - младший научный сотрудник научно-клинического отдела травматологии, врач травматолог-ортопед травматолого-ортопедического отделения клиники.</p><p>664003, Иркутск, ул. Борцов Революции</p></bio><bio xml:lang="en"><p>Chingiz Z. Butaev - Junior Research Officer at the Scientific Clinical Department of Traumatology.</p><p>Bortsov Revolyutsii str. 1, Irkutsk 664003</p></bio><email xlink:type="simple">chingiz-2307@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куклин</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuklin</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куклин Игорь Александрович - доктор медицинских наук, ведущий научный сотрудник научно-клинического отдела травматологии.</p></bio><bio xml:lang="en"><p>Igor A. Kuklin - Dr. Sc. (Med.), Leading Research Officer at the Scientific Clinical Department of Traumatology.</p><p>Bortsov Revolyutsii str. 1, Irkutsk 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ Иркутский научный центр хирургии и травматологии</institution></aff><aff xml:lang="en"><institution>Irkutsk Scientific Centre of Surgery and Traumatology</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2019</year></pub-date><volume>4</volume><issue>6</issue><fpage>72</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бутаев Ч.З., Куклин И.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Бутаев Ч.З., Куклин И.А.</copyright-holder><copyright-holder xml:lang="en">Butaev C.Z., Kuklin I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/2200">https://www.actabiomedica.ru/jour/article/view/2200</self-uri><abstract><p>Ладонный фасциальный фиброматоз Дюпюитрена, заболевание, широко распространённое среди населения разных стран (3 %), в большей степени поражает трудоспособное мужское население. Прогрессирующий характер течения ладонного фасциального фиброматоза Дюпюитрена является причиной стойкого и значительного снижения функциональных возможностей кистей пациентов и приводит к ограничению тонкой и высокоточной деятельности в среднем у 67 % больных, а у 3 % - к инвалидности. Проблема лечения пациентов с контрактурой Дюпюитрена сохраняет свою актуальность несмотря на достижения хирургии кисти. А большое количество применяемых методик говорит как об актуальности проблемы, так и о возможности разностороннего подхода к лечению пациентов с данным заболеванием на разных стадиях и с разной степенью выраженности контрактуры пальцев кисти.</p><p>Описано множество методик лечения контрактуры Дюпюитрена и их модификаций. Это и обширные хирургические вмешательства, подразумевающие иссечение ладонного апоневроза полностью, и селективные открытые вмешательства, подразумевающие удаление только макроизменённыхучастков - тяжей ладонного апоневроза через один большой или несколько мелких доступов. С развитием миниинвазивной техники получили распространение игольчатые способы апоневротомии, не подразумевающие удаление патологически изменённых тканей, а только снятие напряжения в тяже его рассечением и тем самым увеличение движений в суставах пальцев кисти. С развитием фармакологии появились методы ферментативного разрушения тяжа патологически изменённого ладонного апоневроза.</p><p>Эволюция подходов к лечению контрактуры Дюпюитрена видна в постепенном переходе от полного иссечения ладонного апоневроза к селективным методикам, а от них - к частичным рассечениям и далее к игольчатым и ферментативным методам. Однако несмотря на обилие методик и хорошие результаты лечения пациентов с этой патологией, остаётся процент рецидивов, осложнений и неблагоприятных исходов, уменьшение количества которых и является целью развития современного понимания этой патологии.</p></abstract><trans-abstract xml:lang="en"><p>Dupuytren disease is widespread among the population of different countries (3 %) and affects the working-age male population to a greater extent.</p><p>The progressive nature of the course of Dupuytren disease causes a persistent and significant decrease in the functional capabilities of the hands of patients and leads to a limitation of fine and high-precision activity on average in 67 % of patients, and in 3 % causes disability.</p><p>The problem of treating patients with Dupuytren's contracture remains relevant despite the achievements ofhand surgery. A large number of applied methods speaks of both the urgency of the problem and the possibility of a comprehensive approach to treating patients with this disease at different stages and with varying degrees of severity of contracture of the fingers. Many techniques for treating Dupuytren's contracture and their modifications are described. These are extensive surgical interventions, which involve the complete excision of the palmar aponeurosis, and selective open interventions, which involve the removal of only macro-modified areas - the bundle of the palmar aponeurosis through one large or several small accesses. With the development of minimally invasive techniques, needle-based aponeurotomy methods have spread, which do not imply the removal of pathologically altered tissues, but only relieve tension in the tissue by dissecting it and thereby increase movements in the joints of the fingers. With the development of pharmacology, methods for the enzymatic destruction of the bundle of pathologically altered palmar aponeurosis have appeared.</p><p>The evolution of approaches to the treatment of Dupuytren's contracture is visible in a gradual transitionfrom complete excision of the palmar aponeurosis to selective techniques, and from them to partial dissections and further to needle and enzymatic methods. However, despite the abundance of methods and good results in treating patients with this pathology, there remains a percentage of relapses, complications and adverse outcomes, the reduction of which is the purpose of developing a modern understanding of this pathology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>контрактура Дюпюитрена</kwd><kwd>ладонный фасциальный фиброматоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Dupuytren's contracture</kwd><kwd>palmar fascial fibromatosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ling RS. The genetic factor in dupuytren's disease. JBone JointSurg Br. 1963; 45B(4): 709-718.</mixed-citation><mixed-citation xml:lang="en">Ling RS. The genetic factor in dupuytren's disease. 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