actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2019-4.5.17actabiomedica-2178Research ArticleХИРУРГИЯSURGERYСпорные вопросы этиологии и патогенеза третичного гиперпаратиреозаDisputable Issues of Etiology and Pathogenesis of Tertiary Hyperparathyroidismhttps://orcid.org/0000-0002-6887-8325БерсеневГ. А.BersenevG. A.

аспирант, ФГБНУ «Иркутский научный центр хирургии и травматологии»

664003, Иркутск, ул. Борцов Революции, 1, Россия

Postgraduate

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

glbersenev17@gmail.comhttps://orcid.org/0000-0002-2081-8665ИльичёваЕ. А.IlyichevaE. A.

доктор медицинских наук, профессор, заведующая научным отделом клинической хирургии; врач-хирург торакального хирургического отделения

664003, Иркутск, ул. Борцов Революции, 1, Россия

Dr. Sc. (Med.), Professor, Head of the Scientific Department of Clinical Surgery; Thoracic Surgeon at the Thoracic Surgical Department,

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

KrasnogoVosstaniya str. 1, Irkutsk 664003, Russian Federation

lena_isi@mail.ruhttps://orcid.org/0000-0002-2440-0813БулгатовД. А.BulgatovD. A.

аспирант

664003, Иркутск, ул. Борцов Революции, 1, Россия

664003, г. Иркутск, ул. Красного Восстания, 1, Россия

Postgraduate

Bortsov Revolyutsii str. 1, Irkutsk 664003, Russian Federation

bbd-x@mail.ruФГБНУ «Иркутский научный центр хирургии и травматологии»Irkutsk Scientific Centre of Surgery and TraumatologyФГБНУ «Иркутский научный центр хирургии и травматологии»Irkutsk Scientific Centre of Surgery and Traumatology, Irkutsk Regional Clinical HospitalФГБНУ «Иркутский научный центр хирургии и травматологии», ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РоссииIrkutsk State Medical University20191311201945104115Copyright © Берсенев Г.А., Ильичёва Е.А., Булгатов Д.А., 20192019Берсенев Г.А., Ильичёва Е.А., Булгатов Д.А.Bersenev G.A., Ilyicheva E.A., Bulgatov D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/2178

Гиперпаратиреоз является клинико-лабораторным синдромом, который характеризуется повышенной продукцией паратиреоидного гормона основными клетками околощитовидных желёз, нарушением фосфорно-кальциевого обмена и поражением органов-мишеней (почки, костная ткань). Выделяют первичный, вторичный и третичный гиперпаратиреоз. Данный обзор литературы посвящён вопросам этиологии и патогенеза третичного гиперпаратиреоза.Обзор включает разделы: определение понятий различных форм гиперпаратиреоза; роль витамина D в регуляции фосфорно-кальциевого обмена; развитие третичного гиперпаратиреоза у пациентов с хронической болезнь почек; развитие третичного гиперпаратиреоза у пациентов после трансплантации почек; развитие третичного гиперпаратиреоза у пациентов с дефицитом витамина D.Цель: целью данного обзора литературы является изучение имеющихся на сегодняшний день данных о понятии, этиологии и патогенезе третичного гиперпаратиреоза.Методология. Выполнен обзор литературы в англоязычных базах данных MEDLINE (Pubmed), Scopus, Cochlear library, используя ключевые слова: «secondary hyperparathyroidism pathogenesis diagnosis treatment», «tertiary hyperparathyroidism pathogenesis diagnosis treatment», «development of tertiary hyperparathyroidism from secondary hyperparathyroidism», «chronic vitamin D deficiency, hyperparathyroidism», «early stages of chronic renal failure, hyperparathyroidism». Так же был выполнен поиск в русскоязычной базе данных elibrary, используя ключевые слова: «вторичный гиперпаратиреоз патогенез, диагностика лечение», «третичный гиперпаратиреоз патогенез, диагностика, лечение», «прогрессирование вторичного гиперпаратиреоза», «дефицит витамина D и гиперпаратиреоз». Критерием отбора являлся возраст статей не старше 15 лет от момента публикации.Обсуждение. Как отсутствие единого понимания определения данной проблемы, так наличие многообразных и противоречивых данные об этиологии и патогенезе говорят о необходимости дальнейшего изучения вопроса третичного гиперпаратиреоза. 

Hyperparathyroidism is a clinical and laboratory syndrome characterized by high production of the chief cells of the parathyroid hormone, a calcium-phosphorus metabolism disorder and the organ failure (kidneys, bone tissue).There are primary, secondary and tertiary hyperparathyroidism.This literature review is focused on tertiary hyperparathyroidism and includes the following sections: definition of different forms of hyperparathyroidism, the role of vitamin D in the tertiary hyperparathyroidism development, the development of tertiary hyperparathyroidism in chronic kidney disease patients, the development of tertiary hyperparathyroidism in patients after kidney transplantation, differential diagnosis various forms of hyperparathyroidism, indications for surgical tertiary hyperparathyroidism treatment in patients with kidney disease, in patients with normal kidney function.Objective. The objective of this literature review is to study the current information about this definition, pathogenesis, diagnosis and treatment of tertiary hyperparathyroidism.Methodology. The literature review was taken in English data bases MEDLINE (Pubmed), Scopus, Cochlear library, using following keywords: “secondary hyperparathyroidism pathogenesis diagnosis treatment”, “tertiary hyperparathyroidism pathogenesis diagnosis treatment”, “development of tertiary hyperparathyroidism from secondary hyperparathyroidism”, “chronic vitamin D deficiency, hyperparathyroidism”, “early stages of chronic renal failure, hyperparathyroidism”. Also, search for the same keywords was completed in Russian data base Elibrary.Discussion. Both the lack of a common understanding of this problem, and the presence of diverse and contradictory data of the etiology and pathogenesis indicate the need for further study of tertiary hyperparathyroidism.

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The authors declare that there are no conflicts of interest present.