actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2019-4.5.16actabiomedica-2177Research ArticleХИРУРГИЯSURGERYРоль факторов роста при спаечном процессе в брюшной полостиRole of Growth Factors in the Adhesive Process in the Abdominal Cavityhttps://orcid.org/0000-0002-2540-4525ДреминаН. Н.DreminaN. N.

кандидат биологических наук, старший научный сотрудник лаборатории клеточных технологий и регенеративной медицины

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

Cand. Sc. (Biol.), Senior Research Officer at the Laboratory of Cell Technologies and Regenerative Medicine

Bortsov Revolutsii str. 1, Irkutsk 664003, Russian Federation

iscst@mail.ruhttps://orcid.org/0000-0001-5921-0318ШурыгинМ. Г.ShuryginM. G.

доктор медицинских наук, заведующий научно-лабораторным отделом

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

Dr. Sc. (Med.), Head of the Scientific Laboratory Department

Bortsov Revolutsii str. 1, Irkutsk 664003, Russian Federation

iscst@mail.ruhttps://orcid.org/0000-0002-3197-4276ЧепурныхЕ. Е.ChepurnikhE. E.

кандидат медицинских наук, учёный секретарь; доцент кафедры госпитальной хирургии

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

664003, г. Иркутск, ул. Красного Восстания, 1, Россия

Cand. Sc. (Med.), Academic Secretary; Associate Professor at the Department of Advanced Level Surgery

Bortsov Revolutsii str. 1, Irkutsk 664003, Russian Federation

Krasnogo Vosstaniya str. 1, Irkutsk 664003, Russian Federation

iscst@mail.ruhttps://orcid.org/0000-0003-3980-050XШурыгинаИ. А.ShuryginaI. A.

доктор медицинских наук, профессор РАН, заместитель директора по научной работе

664003, г. Иркутск, ул. Борцов Революции, 1, Россия

Dr. Sc. (Med.). Professor of RAS, Deputy Director for Science

Bortsov Revolutsii str. 1, Irkutsk 664003, Russian Federation

iscst@mail.ruФГБНУ «Иркутский научный центр хирургии и травматологии»Irkutsk Scientific Centre of Surgery and TraumatologyФГБНУ «Иркутский научный центр хирургии и травматологии», ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РоссииIrkutsk Scientific Centre of Surgery and Traumatology; Irkutsk State Medical University2019131120194598103Copyright © Дремина Н.Н., Шурыгин М.Г., Чепурных Е.Е., Шурыгина И.А., 20192019Дремина Н.Н., Шурыгин М.Г., Чепурных Е.Е., Шурыгина И.А.Dremina N.N., Shurygin M.G., Chepurnikh E.E., Shurygina I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/2177

Факторы роста – высокоспециализированные биологически активные низкомолекулярные полипептиды, контролирующие процессы роста, развития и поддержания клеточных популяций. Систематический обзор посвящён роли различных факторов роста в развитии спаечного процесса в брюшной полости. Показано, что в развитии спаечного процесса в брюшной полости участвуют такие факторы роста, как ростовой фактор эндотелия сосудов, фактор роста фибробластов, трансформирующий фактор роста, тромбоцитарный фактор роста, инсулиноподобный ростовой фактор и фактор роста кератиноцитов. Каждый из перечисленных факторов вносит значительный вклад в процесс образования перитонеального фиброза. В развитии непосредственно спаечного процесса в брюшной полости главной молекулой является TGF-β1. На ранних сроках после повреждения перитонеальной брюшины значимое влияние оказывают вазоэндотелиальный фактор роста и фактор роста соединительной ткани. Показано, что блокирование трансформирующего фактора роста, вазоэндотелиального фактора роста, инсулиноподобного фактора роста, а также рецептора эпидермального фактора роста ослабляет перитонеальный фиброз.Таким образом, повреждение любой ткани инициирует сложный многоступенчатый процесс, который регулируется большим количеством цитокинов и факторов роста. Ростовые факторы контролируют миграцию, пролиферацию, дифференцировку и выживание клеток. Кроме того, они способны влиять на экспрессию других факторов, участвующих в регенеративном ответе. Понимание процесса, развивающегося при формировании спаечного процесса в брюшной полости и влияющих на него ростовых факторов имеет важное значение для дальнейшего применения их с целью предотвращения патологического процесса.

Fibroproliferative diseases have been described in the lungs, kidneys, liver, eyes, heart, skin, and abdomen. Each fibrous pathology has causal factors and pathological manifestations characteristic of this organ and this condition. However, there are common mechanisms underlying many fibrous pathologies. This gives potential value to studies focused on specific processes, among which is the adhesive process in the abdominal cavity. The study of growth factors in the formation of connective tissue contributes to a better understanding of the pathogenetic picture in this pathology. It is shown that vascular endothelial growth factor, fibroblast growth factor, transforming growth factor, platelet growth factor, insulin-like growth factor and keratinocyte growth factor participate in the development of abdominal adhesions. Each of these factors contributes significantly to the formation of peritoneal fibrosis.Thus, damage to any tissue initiates a complex multistage process, which is regulated by a large number of cytokines and growth factors. Growth factors control cell migration, proliferation, differentiation, and survival. In addition, they are able to influence the expression of other factors involved in the regenerative response. Understanding the process that develops during the formation of the adhesive process in the abdominal cavity and the growth factors affecting it is important for their further use in order to prevent the pathological process.

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The authors declare that there are no conflicts of interest present.