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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2019-4.4.24</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-2138</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPHTHALMOLOGY</subject></subj-group></article-categories><title-group><article-title>Характеристика соматического статуса и отдельных биохимических маркеров у пациентов с окклюзией ретинальных вен</article-title><trans-title-group xml:lang="en"><trans-title>Characteristics of Somatic Status and Individual Biochemical Markers in Patients with Retinal Vein Occlusion</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0884-5513</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Злобин</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zlobin</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Злобин Игорь Владимирович – кандидат медицинских наук, врач-офтальмолог</p><p>664033, г. Иркутск, ул. Лермонтова, 337</p></bio><bio xml:lang="en"><p>Igor V. Zlobin – Cand. Sc. (Med.), Ophthalmologist</p><p>337 Lermontov str., 664033 Irkutsk</p></bio><email xlink:type="simple">zlobig@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0547-7521</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрьева</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Iureva</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юрьева Татьяна Николаевна – доктор медицинских наук, профессор, заместитель директора по научной работе, Иркутский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава России; профессор кафедры офтальмологии, Иркутская государственная медицинская академия последипломного образования664033, г. Иркутск, ул. Лермонтова, 337; 664049, г. Иркутск, Юбилейный, 100</p></bio><bio xml:lang="en"><p>Tatiana N. Iureva – Dr. Sc. (Med.), Professor, Deputy Director for Science, Irkutsk Branch of S. Fyodorov Eye Microsurgery Federal State Institution, Professor at the Department of Ophtalmology, Irkutsk State Medical Academy of Postgraduate Education 337 Lermontov str., 664033 Irkutsk; 100 Yubileyniy, 664049 Irkutsk</p></bio><email xlink:type="simple">tnyurieva@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4264-4408</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курсакова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kursakova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Курсакова Юлия Владимировна – заведующая лабораторией</p><p>664033, г. Иркутск, ул. Лермонтова, 337</p></bio><bio xml:lang="en"><p>Yulia V. Kursakova – Head of the Laboratory</p><p>337 Lermontov str., 664033 Irkutsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава России</institution></aff><aff xml:lang="en"><institution>Irkutsk Branch of S. Fyodorov Eye Microsurgery Federal State Institution</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Иркутский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова; &#13;
Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff><aff xml:lang="en"><institution>Irkutsk Branch of S. Fyodorov Eye Microsurgery Federal State Institution; Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>25</day><month>08</month><year>2019</year></pub-date><volume>4</volume><issue>4</issue><fpage>150</fpage><lpage>156</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Злобин И.В., Юрьева Т.Н., Курсакова Ю.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Злобин И.В., Юрьева Т.Н., Курсакова Ю.В.</copyright-holder><copyright-holder xml:lang="en">Zlobin I.V., Iureva T.N., Kursakova Y.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/2138">https://www.actabiomedica.ru/jour/article/view/2138</self-uri><abstract><p>Окклюзия вен сетчатки – одно из тяжелейших сосудистых поражений органа зрения, как правило, сопровождающееся соматической патологией.</p><p>Целью исследования явилось изучение соматического статуса и отдельных биохимических маркеров у пациентов с окклюзией вен сетчатки и сравнение в группах, оппозитных по эффективности анти-VEGF терапии.</p><sec><title>Методы</title><p>Методы. Было обследовано 84 пациента с макулярным отёком на фоне окклюзии ретинальных вен, которым с лечебной целью проводились интравитреальные инъекции ингибитора ангиогенеза. В дальнейшем, в зависимости от эффективности лечения, пациенты были разделены на две группы, в которых проводился ретроспективный сравнительный анализ соматического статуса и лабораторных данных. Результаты. Было показано, что пациенты с окклюзией ретинальных вен имеют существенные нарушения со стороны соматического статуса, биохимических параметров крови и коагулограммы. Причём имеется прямая зависимость между тяжестью соматических изменений и глазных проявлений заболевания. Полученные данные отражают явную тенденцию у пациентов с окклюзией вен сетчатки к высокому риску сердечно-сосудистых осложнений, в том числе и окклюзивных поражений. У пациентов в группе с недостаточным эффектом лечения выявлено более тяжёлое течение артериальной гипертензии с повышенным риском стратификации.</p></sec><sec><title>Заключение</title><p>Заключение. Соматический статус и лабораторные показатели пациентов с окклюзией вен сетчатки значительно отличаются от нормы, что необходимо учитывать в прогнозе течения офтальмологического заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><p>Retinal vein occlusion is one of the most severe vascular lesions of the organ of vision, usually accompanied by somatic pathology.</p><p>The aim of the study was to study the somatic status and individual biochemical markers in patients with retinal vein occlusion and comparison in groups opposing the effectiveness of anti-VEGF therapy.</p><sec><title>Methods</title><p>Methods. 84 patients with macular edema were examined on the background of retinal vein occlusion, who underwent intravitreal injections of an angiogenesis inhibitor for therapeutic purposes. Further, depending on the effectiveness of treatment, the patients were divided into 2 groups, in which a retrospective comparative analysis of somatic status and laboratory data was performed.</p></sec><sec><title>Results</title><p>Results. It was shown that patients with occlusion of the retinal veins have significant impairments in terms of somatic status, blood biochemical parameters and coagulogram. Moreover, there is a direct relationship between the severity of somatic changes and ocular manifestations of the disease. The data obtained reflect a clear tendency in patients with occlusion of the retinal veins to a high risk of cardiovascular complications, including occlusive lesions. In patients with an insufficient treatment effect, a more severe course of arterial hypertension with an increased risk of stratification was detected.</p></sec><sec><title>Conclusion</title><p>Conclusion. The somatic status and laboratory parameters of patients with retinal vein occlusion are significantly different from the norm, which must be taken into account in the prognosis of the course of an ophthalmologic disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>окклюзия вен сетчатки</kwd><kwd>окклюзия ретинальных вен</kwd><kwd>соматический статус</kwd><kwd>артериальная гипертензия</kwd><kwd>анти-VEGF терапия</kwd><kwd>ранибизумаб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>retinal vein occlusion</kwd><kwd>retinal vein occlusion</kwd><kwd>somatic status</kwd><kwd>arterial hypertension</kwd><kwd>anti-VEGF therapy</kwd><kwd>ranibizumab</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cugati S, Wang JJ, Rochtchina E, Mitchell P. 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