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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2019-4.1.15</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-1985</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SURGERY</subject></subj-group></article-categories><title-group><article-title>Хромогастродуоденоскопия в диагностике язвенного поражения у пациентов c сердечной-сосудистой патологией в сочетании с анемией</article-title><trans-title-group xml:lang="en"><trans-title>Chromogastroduodenoscopy in Diagnostics of Ulcerative Lesions in Patients with Cardiovascular Pathology in Anemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5653-2960</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Архипова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Arkhipova</surname><given-names>Anna A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Архипова Анна Александровна – кандидат медицинских наук</p></bio><bio xml:lang="en"><p>Cand. Sc. (Med.)</p></bio><email xlink:type="simple">ierusalimova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4071-955X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsov</surname><given-names>Aleksey V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецов Алексей Владимирович – доктор медицинских наук, заведующий отделением</p><p>профессор кафедры факультетской хирургии педиатрического факультета</p></bio><bio xml:lang="en"><p>Dr. Sc. (Med.), Head of the Unit</p><p>Professor at the Department of Intermediate Level Surgery of Pediatric Faculty</p></bio><email xlink:type="simple">1xo2788353@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ НСО «Городская клиническая больница № 2»</institution></aff><aff xml:lang="en"><institution>City Clinical Hospital N 2</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; &#13;
ГБУЗ НСО «Городская клиническая больница № 2»</institution></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University; &#13;
City Clinical Hospital N 2</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>03</day><month>04</month><year>2019</year></pub-date><volume>4</volume><issue>1</issue><fpage>102</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Архипова А.А., Кузнецов А.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Архипова А.А., Кузнецов А.В.</copyright-holder><copyright-holder xml:lang="en">Arkhipova A.A., Kuznetsov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/1985">https://www.actabiomedica.ru/jour/article/view/1985</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. У коморбидных пациентов с анемией при стандартной эзофагогастродуоденоскопии не всегда удаётся обнаружить «плоский» дефект слизистой под фибрином. Известно, что при орошении слизистой желудка раствором метиленового синего её рельеф становится более отчётливым.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: улучшить визуализацию острых плоских язв на анемизированной слизистой желудка и двенадцатиперстной кишки с помощью применения хромогастродуоденоскопии с раствором метиленового синего.</p></sec><sec><title>Методы</title><p>Методы. Хромогастродуоденоскопия с 0,25%-м и 0,5%-м растворами метиленового синего использовалась у 28 пациентов (17 (60,7 %) женщин, 11 (39,3 %) мужчин; возраст 53–86 лет), госпитализированных по поводу острой и хронической сердечно-сосудистой патологии в условиях анемии. Эндоскопическое исследование проводилось в условиях реанимации или палаты интенсивной терапии. Критерием исключения служил отказ пациента от проведения исследования. Ключевым исходом считалось выявления дефекта слизистой (эрозии, язвы).</p></sec><sec><title>Результаты</title><p>Результаты. После применения хромогастродуоденоскопии с метиленовым синим был верно поставлен диагноз 5 (17,8 %) пациентам, у которых патологический процесс без контрастирования верифицировать не удавалось. В ходе выполнения хромогастродуоденоскопии с метиленовым синим побочных эффектов не выявлено.</p></sec><sec><title>Заключение</title><p>Заключение. Хромогастродуоденоскопия с метиленовым синим имеет большое практическое значение как информативный и простой метод.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Rationale</title><p>Rationale. Standard esophagogastroduodenoscopy does not always detect ‘plain’ defects of mucosa with fibrin in comorbid patients with anemia. It is known that irrigation of gastric mucosa with methylene blue solution makes the relief more distinct.</p></sec><sec><title>Objective</title><p>Objective: to improve imaging of acute plain ulcers at anematized mucosa of stomach and duodenum using chromogastroduodenoscopy with methylene blue solution.</p></sec><sec><title>Methods</title><p>Methods. Chromogastroduodenoscopy with 0.25% and 0.5% methylene blue solution was used in 28 patients (aged 53–86; 17 (60.7 %) women, 11 (39.3 %) men) hospitalized for acute and chronic cardiovascular pathology in anemia. The endoscopic examination was carried out in reanimation or intensive care units. The exclusion criterion was the patient’s refusal to participate in the study. The key outcome was identification of mucosa defects (erosion, ulcer).</p></sec><sec><title>Results</title><p>Results. Chromastroduodenoscopy with methylene blue allowed correct diagnosing of 5 patients (17.8 %) in which pathological processes could not be verified without contrasting. Improved visualization of mucosal defects during contrasting was obtained due to the following:</p><p>– the colorant spreading over the surface of the mucous accumulates in folds and grooves, erosions, ulcers, thereby showing the configuration;</p><p>– in stomach methylene blue does not color normal mucosa, but colors fibrin in the base of the defect. And in duodenum it colors mucosa and fibrin in the base of the ulcerative defect, while the edges of the defect are colored unevenly and are visualized as a rim during the imaging. No side effects were identified in the course of chromogastroduodenoscopy with methylene blue.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хромогастродуоденоскопия</kwd><kwd>метиленовый синий</kwd><kwd>язва</kwd><kwd>эрозия</kwd><kwd>анемизированная слизистая</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chromogastroduodenoscopy</kwd><kwd>methylene blue</kwd><kwd>ulcer</kwd><kwd>erosion of anematized mucosa</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FK, Furberg CD, et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am J Gastroenterol. 2008; 103(1): 2890- 2907. doi: 10.1111/j.1572-0241.2008.02216.x</mixed-citation><mixed-citation xml:lang="en">Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FK, Furberg  CD, et  al. 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