By means of calculation of the incidence mean value, the amplitude of oscillation and a dynamic analysis, we investigated data from official statistical collections of the Federal State Statistics Service (Public Health in Russia, Russian Statistical Yearbook). We assessed the incidence rate using medical aid appealability of adolescents (15-І7 years) in the Russian Federation and Novosibirsk region during the period from 2004 to 2013. A comparative dynamic analysis of general incidence of the adolescents of the Russian Federation and Novosibirsk region has shown that the medical referral level is higher in the Russian Federation by 33.8 % with an average increase by 3.4 % per year on average, especially for such types of diseases as digestive diseases, diseases of the endocrine system, diseases of the musculoskeletal system and connective tissue, circulatory system diseases, diseases of the eye and adnexa, diseases of the ear and mastoid process, nervous system diseases (44.1 %; 31.9 %; 26.0 %; 24.9 %; 23.8 %; 22.9 %; 21.3 %; 19.8 % respectively); the medical referral level of Novosibirsk region was higher by 30.2 % with an average increase by 3.0 % per year on average, infectious and parasitic pathology was higher by 43.0 % mainly. The differences in the levels of medical help and the structure of the main types of diseases that determine the nature of adolescent morbidity in the Russian Federation and Novosibirsk region, which predetermines the need to ensure appropriate coordination of medical activities and services.