actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-1702Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSАлкогольная зависимость, сформированная на фоне нарушений психической адаптацииAlcohol dependence is formed on the background of violations of mental adaptationАгибаловаТ. В.AgibalovaT. V.agibalovatv@mail.ruРычковаО. В.RychkovaO. V.agibalovatv@mail.ruКузнецовА. Г.KuznetsovA. G.noemail@neicon.ruГуревичГ. Л.GurevichG. ..noemail@neicon.ruНедобыльскийО. В.NedobilskyO. ..noemail@neicon.ruФедеральное государственное бюджетное учреждение Национальный научный центр наркологии МЗ РФРоссияNational Scientific Center for Research on Addictions of the Russian Ministry of HealthcareRussian FederationФГБУ Национальный научный центр наркологии МЗ РФРоссияNational Scientific Center for Research on Addictions of the Russian Ministry of HealthcareRussian Federation20132811201306169176Copyright © Агибалова Т.В., Рычкова О.В., Кузнецов А.Г., Гуревич Г.Л., Недобыльский О.В., 20132013Агибалова Т.В., Рычкова О.В., Кузнецов А.Г., Гуревич Г.Л., Недобыльский О.В.Agibalova T.V., Rychkova O.V., Kuznetsov A.G., Gurevich G..., Nedobilsky O...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/1702

Статья посвящена анализу имеющихся данных литературы о роли хронического стресса в развитии зависимости от психоактивных веществ, в том числе алкоголя, с акцентом на нейрохимических механизмах, обеспечивающих такое влияние, и анализом подходов к терапии алкогольной зависимости, сформированной на фоне нарушений адаптации.

This review of literature describes a role of chronic stress in the development of substance dependence including alcohol dependence. It is focused on neurochemical mechanisms of this dependence and approaches to its treatment in people with mental adaptation disorders.

алкогольная зависимостьнарушения адаптациипролонгированный инъекционный налтрексонalcohol abuseadjustment disorderslong-acting injectable naltrexoneReferencesАнохина И.П. Биологические механизмы зависимости от психоактивных веществ // Вопросы наркологии. - 1995. - № 2. - С. 27-31.Анохина И.П. Биологические механизмы зависимости от психоактивных веществ // Вопросы наркологии. - 1995. - № 2. - С. 27-31.Анохина И.П., Коган Б.М. Нарушения различных звеньев регуляции катехоламиновой нейромедиации при алкоголизме // Вопросы наркологии. - 1988. -№ 3. - С. 3-6.Анохина И.П., Коган Б.М. Нарушения различных звеньев регуляции катехоламиновой нейромедиации при алкоголизме // Вопросы наркологии. - 1988. -№ 3. - С. 3-6.Селье Г. Стресс без дистресса. - М: Прогресс, 1979. - 123 с.Селье Г. Стресс без дистресса. - М: Прогресс, 1979. - 123 с.Хомская Е.Д. Нейропсихология: 4-е издание. -СПб.: Питер, 2005. - 496 с.Хомская Е.Д. Нейропсихология: 4-е издание. -СПб.: Питер, 2005. - 496 с.Arnsten A.F., Li B.M. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions // Biol. Psychiatry. - 2005. -Vol. 57. -P. 1377-1384.Arnsten A.F., Li B.M. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions // Biol. Psychiatry. - 2005. -Vol. 57. -P. 1377-1384.Berridge C.W. Noradrenergic modulation of arousal // Brain Res. Rev. - 2007. - Vol. 58 (1). - P. 1-17.Berridge C.W. Noradrenergic modulation of arousal // Brain Res. Rev. - 2007. - Vol. 58 (1). - P. 1-17.Berridge K.C. Pleasure, pain, desire and dread: hidden core processes of emotion, in Well Being: The Foundations of Hedonic Psychology / Ed. by D. Kahneman, E. Diener, N. Schwarz. - New York, Russell Sage Foundation, 1999. - P. 525-557.Berridge K.C. Pleasure, pain, desire and dread: hidden core processes of emotion, in Well Being: The Foundations of Hedonic Psychology / Ed. by D. Kahneman, E. Diener, N. Schwarz. - New York, Russell Sage Foundation, 1999. - P. 525-557.Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? // Brain Res Brain Res Rev. - 1998. -Vol. 28. - P. 309-369.Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? // Brain Res Brain Res Rev. - 1998. -Vol. 28. - P. 309-369.Blum K., Chen A., Giordano J. et al. The Addictive Brain: All Roads Lead to Dopamine // J. Psychoactive Drugs. - 2012. - Vol. 44 (2). - P. 134-143.Blum K., Chen A., Giordano J. et al. The Addictive Brain: All Roads Lead to Dopamine // J. Psychoactive Drugs. - 2012. - Vol. 44 (2). - P. 134-143.Blum K., Giordano J., Morse S., Anderson A. et al. Hypothesizing synergy between acupuncture / auriculotherapy and natural activation of mesolimbic dopaminergic pathways: Putative natural treatment modalities for the reduction of drug hunger and relapse. Integrative Omics and Applied Biotechnology Letters. - 2011. -Vol. 1. - P. 8-20.Blum K., Giordano J., Morse S., Anderson A. et al. Hypothesizing synergy between acupuncture / auriculotherapy and natural activation of mesolimbic dopaminergic pathways: Putative natural treatment modalities for the reduction of drug hunger and relapse. Integrative Omics and Applied Biotechnology Letters. - 2011. -Vol. 1. - P. 8-20.Blum K., Noble E.P., Sheridan P.J., Montgomery A. et al. Allelic association of human dopamine D2 receptor gene in alcoholism // Journal of the American Medical Association. - 1990. - Vol. 263 (15). - P. 2055-2060.Blum K., Noble E.P., Sheridan P.J., Montgomery A. et al. Allelic association of human dopamine D2 receptor gene in alcoholism // Journal of the American Medical Association. - 1990. - Vol. 263 (15). - P. 2055-2060.Charmandari E., Tsigos C., Chrousos G. Endocrinology of the stress response // Annu. Rev. Physiol. -2005. - Vol. 67. - P. 259-284.Charmandari E., Tsigos C., Chrousos G. Endocrinology of the stress response // Annu. Rev. Physiol. -2005. - Vol. 67. - P. 259-284.Conger J.J. Reinforcement theory and the dynamics of alcoholism // Q. J. Stud. Alcohol. - 1956. - Vol. 17. -P. 296-305.Conger J.J. Reinforcement theory and the dynamics of alcoholism // Q. J. Stud. Alcohol. - 1956. - Vol. 17. -P. 296-305.Di Chiara G. A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use // J. Psychopharmacol. - 1998. - Vol. 12. - P. 54-67.Di Chiara G. A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use // J. Psychopharmacol. - 1998. - Vol. 12. - P. 54-67.Floresco S.B., Magyar O. Mesocortical dopamine modulation of executive functions: beyond working memory // Psychopharmacology (Berl). - 2006. - Nov., Vol. 188 (4). - P. 567-85.Floresco S.B., Magyar O. Mesocortical dopamine modulation of executive functions: beyond working memory // Psychopharmacology (Berl). - 2006. - Nov., Vol. 188 (4). - P. 567-85.Jolas T., Nestler E.J., Aghajanian G.K. Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an upregulation of the cyclic AMP pathway // Neuroscience. - 2000. -Vol. 95. - P. 433-443.Jolas T., Nestler E.J., Aghajanian G.K. Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an upregulation of the cyclic AMP pathway // Neuroscience. - 2000. -Vol. 95. - P. 433-443.Koob G.F., Le Moal M. Drug abuse: hedonic homeostatic dysregulation // Science. - 1997. -Vol. 278. - P. 52.Koob G.F., Le Moal M. Drug abuse: hedonic homeostatic dysregulation // Science. - 1997. -Vol. 278. - P. 52.Kreek M.J., Koob G.F. Drug dependence: Stress and dysregulation of brain reward pathways // DrugAlcohol Depend. - 1998. - Vol. 51. - P. 23-47.Kreek M.J., Koob G.F. Drug dependence: Stress and dysregulation of brain reward pathways // DrugAlcohol Depend. - 1998. - Vol. 51. - P. 23-47.Lazarus R.S., Folkman S. Stress, appraisal, and coping. - New York: Springer, 1984.Lazarus R.S., Folkman S. Stress, appraisal, and coping. - New York: Springer, 1984.McEwen B.S. Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain // Physiol Rev. - 2007. - Vol. 87. - P. 873-904.McEwen B.S. Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain // Physiol Rev. - 2007. - Vol. 87. - P. 873-904.Muller C.P., Carey R.J., Huston J.P., De Souza Silva M.A. Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors // Progress in Neurobiology. - 2007. -Vol. 81. - P. 133-178.Muller C.P., Carey R.J., Huston J.P., De Souza Silva M.A. Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors // Progress in Neurobiology. - 2007. -Vol. 81. - P. 133-178.Nikolova Y., Hariri A. Neural responses to threat and reward interact to predict stress-related problem drinking: A novel protective role of the amygdale // Biology of Mood & Anxiety Disorders. - 2012. - Vol. 2. - P. 19.Nikolova Y., Hariri A. Neural responses to threat and reward interact to predict stress-related problem drinking: A novel protective role of the amygdale // Biology of Mood & Anxiety Disorders. - 2012. - Vol. 2. - P. 19.Ninan P.T. The Functional Anatomy, Neurochemistry and Pharmacology of Anxiety // J. Clin. Psychiatry. - 1999. - Vol. 60 (22). - P. 12-17.Ninan P.T. The Functional Anatomy, Neurochemistry and Pharmacology of Anxiety // J. Clin. Psychiatry. - 1999. - Vol. 60 (22). - P. 12-17.Phan K.L. et al. Neural substrates for voluntary suppression of negative affect: A functional magnetic resonance imaging study // Biol. Psychiatry. - 2005. -Vol. 57. - P. 210-219.Phan K.L. et al. Neural substrates for voluntary suppression of negative affect: A functional magnetic resonance imaging study // Biol. Psychiatry. - 2005. -Vol. 57. - P. 210-219.Roberts A., Robbins T., Weiskrantz L. The Prefrontal Cortex: Executive and Cognitive Functions. -Oxford University Press; Oxford, UK, 1998.Roberts A., Robbins T., Weiskrantz L. The Prefrontal Cortex: Executive and Cognitive Functions. -Oxford University Press; Oxford, UK, 1998.Russell J.A., Mehrabian A. The mediating role of emotions in alcohol use // J. Stud. Alcohol. - 1975. -Vol. 36. - P. 1508-1536.Russell J.A., Mehrabian A. The mediating role of emotions in alcohol use // J. Stud. Alcohol. - 1975. -Vol. 36. - P. 1508-1536.Salamone J.D., Cousins M.S., Snyder B.J. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis // Neurosci Biobehav. Rev. - 1997. - Vol. 21. - P. 341-359.Salamone J.D., Cousins M.S., Snyder B.J. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis // Neurosci Biobehav. Rev. - 1997. - Vol. 21. - P. 341-359.Schultz W., Dayan P., Montague P.R. A neural substrate of prediction and reward // Science. - 1997. -Vol. 275. - P. 1593-1599.Schultz W., Dayan P., Montague P.R. A neural substrate of prediction and reward // Science. - 1997. -Vol. 275. - P. 1593-1599.Sher K.J., Levenson R.W. Risk for alcoholism and individual differences in the stress-response-dampening effect of alcohol // J. Abnorm. Psychol. - 1982. - Vol. 91. -P. 350-368.Sher K.J., Levenson R.W. Risk for alcoholism and individual differences in the stress-response-dampening effect of alcohol // J. Abnorm. Psychol. - 1982. - Vol. 91. -P. 350-368.Sinha R. Chronic Stress, Drug Use and Vulnerability to Addiction Ann N Y Acad Sci. -2008. - Vol. 1141. -P. 105-130.Sinha R. Chronic Stress, Drug Use and Vulnerability to Addiction Ann N Y Acad Sci. -2008. - Vol. 1141. -P. 105-130.Steinkellner T., Freissmuth M., Sitte H.H., Montgomery T. The ugly side of amphetamines: short-and long-term toxicity of 3,4-methylenedioxymetha mphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine // Biological Chemistry. - 2011. -Vol. 392. - P. 103-115.Steinkellner T., Freissmuth M., Sitte H.H., Montgomery T. The ugly side of amphetamines: short-and long-term toxicity of 3,4-methylenedioxymetha mphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine // Biological Chemistry. - 2011. -Vol. 392. - P. 103-115.Takahashi H., Kato M., Takano H., Arakawa R. et al. Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions // J. Neurosci. - 2008. - Nov 12. - Vol. 28 (46). -P. 12032-12038.Takahashi H., Kato M., Takano H., Arakawa R. et al. Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions // J. Neurosci. - 2008. - Nov 12. - Vol. 28 (46). -P. 12032-12038.Thielen R.J., Bare D.J., McBride W.J., Lumeng L. et al. Ethanol-stimulated serotonin release in the ventral hippocampus: an absence of rapid tolerance for the alcohol-preferring P rat and insensitivity in the alcohol-nonpreferring NP rat // Pharmacology, Biochemistry & Behavior. - 2002. - Vol. 71. - P. 111-117.Thielen R.J., Bare D.J., McBride W.J., Lumeng L. et al. Ethanol-stimulated serotonin release in the ventral hippocampus: an absence of rapid tolerance for the alcohol-preferring P rat and insensitivity in the alcohol-nonpreferring NP rat // Pharmacology, Biochemistry & Behavior. - 2002. - Vol. 71. - P. 111-117.Thielen R.J., Engleman E.A., Rodd Z.A., Murphy J.M. et al. Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats // The Journal of Pharmacology and Experimental Therapeutics. - 2004. - Vol. 309. -P. 216-225.Thielen R.J., Engleman E.A., Rodd Z.A., Murphy J.M. et al. Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats // The Journal of Pharmacology and Experimental Therapeutics. - 2004. - Vol. 309. -P. 216-225.Tice D., Bratslavsky E., Baumeister R. Emotional distress regulation takes precedence over impulse control: If you feel bad, do it! // J. Pers. Soc. Psychol. - 2001. -Vol. 80. - P. 53-67.Tice D., Bratslavsky E., Baumeister R. Emotional distress regulation takes precedence over impulse control: If you feel bad, do it! // J. Pers. Soc. Psychol. - 2001. -Vol. 80. - P. 53-67.Verdejo-Garcia A. et al. Negative emotion-driven impulsivity predicts substance dependence problems // Drug Alcohol Depend. - 2007. - Vol. 91. - P. 213-219.Verdejo-Garcia A. et al. Negative emotion-driven impulsivity predicts substance dependence problems // Drug Alcohol Depend. - 2007. - Vol. 91. - P. 213-219.Waelti P., Dickinson A., Schultz W. Dopamine responses comply with basic assumptions of formal learning theory // Nature. - 2001. - Vol. 412. - P. 43-48.Waelti P., Dickinson A., Schultz W. Dopamine responses comply with basic assumptions of formal learning theory // Nature. - 2001. - Vol. 412. - P. 43-48.Wills, T.; Shiffman, S. Coping and substance abuse: A conceptual framework // In: Shiffman, S.; Wills, T., editors. Coping and Substance Use. Academic Press; Orlando, FL. - 1985. - P. 3-24.Wills, T.; Shiffman, S. Coping and substance abuse: A conceptual framework // In: Shiffman, S.; Wills, T., editors. Coping and Substance Use. Academic Press; Orlando, FL. - 1985. - P. 3-24.Wise R.A., Spindler J., deWit H., Gerberg G.J. Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food // Science. - 1978. - Vol. 201. - P. 262-264.Wise R.A., Spindler J., deWit H., Gerberg G.J. Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food // Science. - 1978. - Vol. 201. - P. 262-264.Yamamoto B.K., Moszczynska A., Gudelsky G.A., Amphetamine toxicities: classical and emerging mechanisms // Annals of the New York Academy of Sciences. - 2010. - Vol. 1187. - P. 101-121.Yamamoto B.K., Moszczynska A., Gudelsky G.A., Amphetamine toxicities: classical and emerging mechanisms // Annals of the New York Academy of Sciences. - 2010. - Vol. 1187. - P. 101-121.Yoshimoto K., McBride W.J., Lumeng L., Li T.K. Alcohol stimulates the release of dopamine and serotonin in the nucleus-accumbens // Alcohol. - 1992. - Vol. 9. -P. 17-22.Yoshimoto K., McBride W.J., Lumeng L., Li T.K. Alcohol stimulates the release of dopamine and serotonin in the nucleus-accumbens // Alcohol. - 1992. - Vol. 9. -P. 17-22.

The authors declare that there are no conflicts of interest present.