actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-1694Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В БИОЛОГИИ И МЕДИЦИНЕEXPERIMENTAL RESEARCHES IN BIOLOGY AND MEDICINEАллельный полиморфизм генов «домашнего хозяйства» нетоксигенных штаммов vibrio cholerae, выделенных на территории Сибири и Дальнего ВостокаAllelic polymorphism of atoxigenic Vibrio Cholerae strains of housekeeping genes isolated in Siberia and Far EastГольдапельЭ. Г.GoldapelE. G.tapuz82@mail.ruМироноваЛ. В.MironovaL. V.mironova-lv@yandex.ruАфанасьевМ. В.Afanas'evM. V.afanasev-max@mail.ruБалахоновС. В.BalakhonovS. V.noemail@neicon.ruФКУЗ «Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока» РоспотребнадзораIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorФКУЗ Иркутский научно-исследовательский противочумный институт РоспотребнадзораIrkutsk Antiplague Research Institute of Rospotrebnadzor20132811201306132135Copyright © Гольдапель Э.Г., Миронова Л.В., Афанасьев М.В., Балахонов С.В., 20132013Гольдапель Э.Г., Миронова Л.В., Афанасьев М.В., Балахонов С.В.Goldapel E.G., Mironova L.V., Afanas'ev M.V., Balakhonov S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/1694

Проведен анализ структуры комплекса генов «домашнего хозяйства» нетоксигенных штаммов Vibrio cholerne. Исследовано 20 изолятов, которые дифференцировались на девять сиквенс-типов, пять из которых -уникальных. Установлена кластеризация по принадлежности к серогруппе: в одну группу вошли все штаммы RO варианта холерного вибриона и один О139 серогруппы, в другую - все штаммы О1 серогруппы. В ряде случаев установлена связь сиквенс-типа с местом и временем выделения штаммов, однако объединение штаммов в наиболее распространенный сиквенс-тип, не зависело от пространственно-временных характеристик.

There were atoxigenic Vibrio cholerae strains housekeeping genes analyzed. There were studied 20 isolates, in which nine sequence types have determined and five of which have described as unique. There were clustersformed as belonging to serogroup: first cluster includes RO-variantstrains and one O139 serogroup strain of V. cholerae, second - all O1 serogroup V. cholerae strains. There are sequence types associated with place and time isolation strains in some cases, although differentiation of the strains, which are formed the dominant sequence type strains group have no spatial and temporal characteristics associated.

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The authors declare that there are no conflicts of interest present.