<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-1461</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФИЛАКТИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PREVENTIVE MEDICINE</subject></subj-group></article-categories><title-group><article-title>РЕЗУЛЬТАТЫ РЕКОГНОСЦИРОВОЧНЫХ ИССЛЕДОВАНИЙ ПО ОБНАРУЖЕНИЮ ОЧАГОВ БАБЕЗИОЗА НА ТЕРРИТОРИИ ИРКУТСКОЙ ОБЛАСТИ</article-title><trans-title-group xml:lang="en"><trans-title>RESULTS OF RECONNAISSANCE STUDIES ON DETECTION OF BABESIOSIS FOCI IN THE IRKUTSK REGION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федулина</surname><given-names>О. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedulina</surname><given-names>O. O.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рар</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rar</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">rarv@niboch.nsc.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сунцова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Suntsova</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Научный центр проблем здоровья семьи и репродукции человека» СО РАМН</institution></aff><aff xml:lang="en"><institution>Scientific Center of Family Health and Human Reproduction Problems SB RAMS</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт химической биологии и фундаментальной медицины СО РАН</institution></aff><aff xml:lang="en"><institution>Institute of Chemical Biology and Fundamental Medicine SB RAS</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2013</year></pub-date><volume>0</volume><issue>2(2)</issue><fpage>130</fpage><lpage>133</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Федулина О.О., Рар В.А., Сунцова О.В., Козлова И.В., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Федулина О.О., Рар В.А., Сунцова О.В., Козлова И.В.</copyright-holder><copyright-holder xml:lang="en">Fedulina O.O., Rar V.A., Suntsova O.V., Kozlova I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/1461">https://www.actabiomedica.ru/jour/article/view/1461</self-uri><abstract><p>В статье приведены результаты рекогносцировочных исследований по поиску очагов бабезиоза в Иркутской области. дНк бабезий обнаружена в клещах двух видов (I. persulcatus, H. сщncinna) на территории трех районов Иркутской области: Эхирит-Булагатского, Иркутского, Шелеховского. Проведен анализ нуклеотидных последовательностей гена 18S рРНК длиной 1220 н.о. пяти образцов бабезий. Показано, что выявленные последовательности бабезий отличаются от ранее известных и относятся к двум генетическим группам. В первую группу вошли бабезии, генетически наиболее схожие с патогеном овец Babesia crassa, ко второй отнесен образец, нуклеотидные последовательности которого существенно отличаются от всех известных (менее 95 % гомологии).</p></abstract><trans-abstract xml:lang="en"><p>This article contains results of reconnaissance studies intended to find foci of babesia in the Irkutsk region. Babesia DNA were founded in two types of ticks (I. persulcatus, H. concinna) in the three districts of the Irkutsk region (Ekhirit-Bulagatsky, Irkutsky, Shelekhovsky). The analysis of 1220 nr length nucleotide sequences of 18S rRNA gene of five Babesia samples was conducted. It was shown that the identified Babesia sequenced differ from previously known, and refer to the two genetic groups. The first group included babesia, genetically most similar to the sheep pathogen Babesia crassa, second contains sample, nucleotide sequence of which is significantly different from all known (less than 95 % homology).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бабезиоз</kwd><kwd>генетическая вариабельность</kwd><kwd>природный очаг</kwd></kwd-group><kwd-group xml:lang="en"><kwd>babesiosis</kwd><kwd>genetic variability</kwd><kwd>natural focus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева И.С. Новые болезни, передаваемые клещами рода Ixodes (Ixodidae). Бабезиозы человека // Пест-Менеджмент = Pest-Management. - 2006. -№ 1. - С. 11-13.</mixed-citation><mixed-citation xml:lang="en">Васильева И.С. Новые болезни, передаваемые клещами рода Ixodes (Ixodidae). Бабезиозы человека // Пест-Менеджмент = Pest-Management. - 2006. -№ 1. - С. 11-13.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Рар В.А., Епихина Т.И., Боляхина С.А. Распространенность и генетическое разнообразие бабезий на территоии Северного Урала, Западной Сибири и Дальнего Востока // В кн: Инфекции, передаваемые клещами в Сибирском регионе. - Вып. 30, Гл. 9. - Новосибирск: Изд-во СО РАН, 2011. - С. 296-308.</mixed-citation><mixed-citation xml:lang="en">Рар В.А., Епихина Т.И., Боляхина С.А. Распространенность и генетическое разнообразие бабезий на территоии Северного Урала, Западной Сибири и Дальнего Востока // В кн: Инфекции, передаваемые клещами в Сибирском регионе. - Вып. 30, Гл. 9. - Новосибирск: Изд-во СО РАН, 2011. - С. 296-308.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bonnet S., Jouglin M., L'Hostis M., Chauvin A. Babesia sp. EU1 from roe deer and transmission within Ixodes ricinus // Emerg. Infect. Dis. - 2007. - № 13. -Р. 1208-1210.</mixed-citation><mixed-citation xml:lang="en">Bonnet S., Jouglin M., L'Hostis M., Chauvin A. Babesia sp. EU1 from roe deer and transmission within Ixodes ricinus // Emerg. Infect. Dis. - 2007. - № 13. -Р. 1208-1210.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Entomologic and serologic evidence of zoonotic transmission of Babesia microti, eastern Switzerland / I.M. Foppa [et al.] // Emerg. Infect. Dis. - 2002. - Vol. 8. -P. 722-726.</mixed-citation><mixed-citation xml:lang="en">Entomologic and serologic evidence of zoonotic transmission of Babesia microti, eastern Switzerland / I.M. Foppa [et al.] // Emerg. Infect. Dis. - 2002. - Vol. 8. -P. 722-726.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gorenflot A., Moubri K., Precigout E. et al. Human babesiosis // Ann. Trop. Med. Parasitol. 1998. - Vol. 92. -P. 489-501.</mixed-citation><mixed-citation xml:lang="en">Gorenflot A., Moubri K., Precigout E. et al. Human babesiosis // Ann. Trop. Med. Parasitol. 1998. - Vol. 92. -P. 489-501.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Herwaldt B.L., Caccio S., Gherlinzoni F. et al. Molecular characterization of a non-Babesia divergens organism causing zoonotic babesiosis in Europe // Emerg. Infect. Dis. - 2003. - Vol. 9. - Р. 942-948.</mixed-citation><mixed-citation xml:lang="en">Herwaldt B.L., Caccio S., Gherlinzoni F. et al. Molecular characterization of a non-Babesia divergens organism causing zoonotic babesiosis in Europe // Emerg. Infect. Dis. - 2003. - Vol. 9. - Р. 942-948.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hunfeld K.P., Brade V. Zoonotic Babesia: possibly emerging pathogens to be considered for tick-infested humans in Central Europe // Int. J. Med Microbiol. -2004. - Vol. 293. - Suppl. 37. - P. 93-103.</mixed-citation><mixed-citation xml:lang="en">Hunfeld K.P., Brade V. Zoonotic Babesia: possibly emerging pathogens to be considered for tick-infested humans in Central Europe // Int. J. Med Microbiol. -2004. - Vol. 293. - Suppl. 37. - P. 93-103.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hunfeld K.P., Hildebrandt A., Gray J.S. Babesiosis: recent insights into an ancient disease // Int. J. Parasitol. -2008. - Vol. 38. - P. 1219-1237.</mixed-citation><mixed-citation xml:lang="en">Hunfeld K.P., Hildebrandt A., Gray J.S. Babesiosis: recent insights into an ancient disease // Int. J. Parasitol. -2008. - Vol. 38. - P. 1219-1237.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hildebrandt A., Hunfeld K.P., Baier M. et al. First confirmed autochthonous case of human Babesia microti infection in Europe // Eur. J. Clin. Microbiol. Infect. Dis. - 2007. - Vol. 26. - P. 595-601.</mixed-citation><mixed-citation xml:lang="en">Hildebrandt A., Hunfeld K.P., Baier M. et al. First confirmed autochthonous case of human Babesia microti infection in Europe // Eur. J. Clin. Microbiol. Infect. Dis. - 2007. - Vol. 26. - P. 595-601.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nakajima R., Tsuji M., Oda K. et al. Babesia microti-group parasites compared phylogenetically by complete sequencing of the CCTeta gene in 36 isolates // J. Vet. Med. Sci. - 2009. - N 71 (1). - P. 55-68.</mixed-citation><mixed-citation xml:lang="en">Nakajima R., Tsuji M., Oda K. et al. Babesia microti-group parasites compared phylogenetically by complete sequencing of the CCTeta gene in 36 isolates // J. Vet. Med. Sci. - 2009. - N 71 (1). - P. 55-68.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Rar V.A., Fomenko N.V., Dobrotvorsky A.K. et al. Tick-borne pathogen detection, Western Siberia, Russia // Emerg. Infect. Dis. - 2005. - Vol. 11, N 11. - P. 17081715.</mixed-citation><mixed-citation xml:lang="en">Rar V.A., Fomenko N.V., Dobrotvorsky A.K. et al. Tick-borne pathogen detection, Western Siberia, Russia // Emerg. Infect. Dis. - 2005. - Vol. 11, N 11. - P. 17081715.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
