actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-141Research ArticleОБЗОРЫREVIEWSВзаимоотношения систем комплемента, Toll-подобных рецепторов, антигенов CD и цитокинов в норме и при патологиях. ОбзорInterrelation between the system of complement, Tolllike receptors, CD antigens and cytokines in normal and pathological condition. ReviewЛахтинМ. В.LakhtinM. V.info@gabrich.comЛахтинВ. М.LakhtinV. M.noemail@neicon.ruАфанасьевС. С.AfanasievS. S.noemail@neicon.ruАлешкинВ. А.AleshkinV. A.noemail@neicon.ruФБУН «МНИИЭМ им. Г.Н. Габричевского» РоспотребнадзораG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology201528112015066266Copyright © Лахтин М.В., Лахтин В.М., Афанасьев С.С., Алешкин В.А., 20152015Лахтин М.В., Лахтин В.М., Афанасьев С.С., Алешкин В.А.Lakhtin M.V., Lakhtin V.M., Afanasiev S.S., Aleshkin V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/141

В обзоре публикаций рассмотрены защитные системы врожденного иммунитета млекопитающих: комплемента, Toll-подобных рецепторов, антигенов CD, других паттерн-распознающих рецепторов и молекул. Приведены данные о таких аспектах указанных систем, как кооперация и синергизм; инициация, переключение, амплификация и терминация путей; стратегии патогенов и контрстратегии хозяина; подходы к созданию адресных механизмов лечения болезней науровне метаболомных узловых коммуникаций; перспективы разработки комбинированных системных препаратов для медицины.

The overview of publications of the last five years is devoted to currently described communicative relationships between complement system, antigens of CD class, Toll-like receptors, other pattern recognition receptors and recognition molecules (interleukins, other cytokines, lectins). Studied aspects of innate immunity system actions include cooperation and synergism; adaptive strategies of microbial and viral pathogens; using probiotic microorganisms; initiation, switching, amplification and termination of key pathways in host antipathogen strategies; approaches to creation of address mechanisms of treatments of diseases at the level of metabolome network communications; prospects for constructing combinative system preparations for medicine.

врожденный иммунитетраспознавание паттерновсистема комплементацитокинылектинывоспалениевирусные и микробные патогеныпробиотические бактерииTLRinnate immunitypattern recognitioncomplement systemToll-like receptorscytokineslectinsprobioticspathogensinflammationprobiotic bacteriaReferencesАфанасьев С.С., Алешкин В.А., Байракова А.Л., Воропаева Е.А., Несвижский Ю.В., Кафарская Л.И., Егорова Е.А. Молекулярные механизмы индукции врожденного иммунитета // Вестник РАМН. - 2009. -№ 4. - С. 42-49Афанасьев С.С., Алешкин В.А., Байракова А.Л., Воропаева Е.А., Несвижский Ю.В., Кафарская Л.И., Егорова Е.А. Молекулярные механизмы индукции врожденного иммунитета // Вестник РАМН. - 2009. -№ 4. - С. 42-49Лахтин М.В., Лахтин В.М., Афанасьев С.С. Система комплемента - коммуникатор иммунитета человека // Materials of the XI International scientific and practical conference «Modern European Science». -2015. - Vol. 8. Medicine. Biological sciences. Chemistry and chemical technology. Ecology. 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The authors declare that there are no conflicts of interest present.