References

actabiomedica

Acta Biomedica Scientifica

2541-94202587-9596

Scientific Centre for Family Health and Human Reproduction Problems

actabiomedica-126

Research Article

ОБЗОРЫ

REVIEWS

КОФУНКЦИОНИРОВАНИЕ ЗАЩИТНЫХ СИСТЕМ: МУКОЗАЛЬНЫЙ ИММУНИТЕТ И СИСТЕМА КОМПЛЕМЕНТА ЧЕЛОВЕКА

COFUNCTIONING OF PROTECTIVE SYSTEMS: MUCOSAL IMMUNITY AND HUMAN COMPLEMENT SYSTEM

Лахтин

М. В.

Lakhtin

M. V.

info@gabrich.com

Лахтин

В. М.

Lakhtin

V. M.

noemail@neicon.ru

Афанасьев

С. С.

Afanasiev

S. S.

noemail@neicon.ru

Алешкин

В. А.

Aleshkin

V. A.

noemail@neicon.ru

ФБУН «МНИИЭМ им. Г.Н. Габричевского» РоспотребнадзораGabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology

2015

28092015

05113122

2015

Лахтин М.В., Лахтин В.М., Афанасьев С.С., Алешкин В.А.

Lakhtin M.V., Lakhtin V.M., Afanasiev S.S., Aleshkin V.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.actabiomedica.ru/jour/article/view/126

В обзоре суммированы данные об антипатогенном кофунщионировании мукозального иммунитета (МИ) и трех путей системы комплемента человека (СКЧ) на этапах активации, усиления и терминации ответа. Учтены рецепторные участники СКЧ и МИ, паттерн-распознающие молекулярные факторы, включая лектиновые. Отмечены случаи использования вирусными и микробными патогенами компонентов и реакций СКЧ и МИ в стратегиях инвазии и выживания в организме. Обозначены перспективы стратегического развития и разработки взаимоотношений МИ и СКЧ для повышения антипатогенного статуса человека.

Results on cofunctioning innate mucosal immunity (MI) and human complement system (HCS) pathways at steps of HCS initiation, amplification and termination were summarized. Receptor participants and pattern recognizing molecules (oligomeric lectins, multifunctional-site mucins and glycoproteins) of HCS and MI are taking into consideration. The ways of antipathogen cofunctioning MI and HCS are shown. The cases of viral, bacterial and fungal pathogens which use components, agent ingredients and reactions of HCS and Ml in pathogen strategies of invasion and survival in organism are represented. Prospects of cofunctioning MI and HCS, strategic directions of MI and HCS combinative using in development of medical aspects, constructing drugs and compositions of medical biotechnology significance are suggested and argued.

мукозальный иммунитетсистема комплементамуцинылектиныпатогенывирусыбактериигрибы

mucosal immunitycomplement systemmucinslectinspathogensvirusesbacteriafungi

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The authors declare that there are no conflicts of interest present.