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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-1213</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS OF LITERATURE</subject></subj-group></article-categories><title-group><article-title>ОСТРАЯ ПЕЧЕНОЧНАЯ НЕДОСТАТОЧНОСТЬ - ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ ИХ РЕШЕНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>ACUTE HEPATIC FAILURE - PROBLEMS AND PROSPECTS OF THEIR DECISION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плеханов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Plekhanov</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">plehanov.a@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Бурятский филиал Научного центра реконструктивной и восстановительной хирургии СО РАМН; ФГБОУ ВПО «Бурятский государственный университет»</institution></aff><aff xml:lang="en"><institution>Buryat branch of Scientific Centre of Reconstructive and Restorative Surgery SB RAMS; Buryat State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2012</year></pub-date><volume>0</volume><issue>5(2)</issue><fpage>150</fpage><lpage>159</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Плеханов А.Н., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Плеханов А.Н.</copyright-holder><copyright-holder xml:lang="en">Plekhanov A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/1213">https://www.actabiomedica.ru/jour/article/view/1213</self-uri><abstract><p>Острая печеночная недостаточность (ОПН) является следствием значительного количества заболеваний печени. В основе патогенеза ОПН лежат процессы некроза, апоптоза и некроапоптоза гепатоцитов. В обзоре проанализирована и обобщена современная информация по вопросу острой печеночной, недостаточности, тем. самым выявлены проблемные вопросы по патогенезу, диагностике и лечению этого драматического осложнения. В мире существует большое количество прогностических тестов исходов ОПН, однако они не всегда могут предсказать течение заболевания и имеют ограниченную ценность.</p></abstract><trans-abstract xml:lang="en"><p>Acute hepatic failure is a cause of a significant amount of liver diseases. In a basis of pathogenesis of acute hepatic failure lie necrotic processes, apoptosis and necroapoptosis of hepatocytes. In this review modern information on a question of acute hepatic failure is analysed and generalized, and. therefore problem questions on pathogenesis, diagnostics and. treatment of this severe complication are revealed. In the world there are plenty prognostic tests of acute hepatic failure outcomes, however they not always can predict current of disease and. have the limited value.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острая печеночная недостаточность</kwd><kwd>этиология</kwd><kwd>патогенез</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>прогноз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute hepatic failure</kwd><kwd>etiology</kwd><kwd>pathogenesis</kwd><kwd>diagnostics</kwd><kwd>therapy</kwd><kwd>the prognosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аруин Л.И. Апоптоз и патология печени // Рос. журн. гастроэнтерол., гепатол., колопроктол. - 1998. - Т. 8, № 2. - С. 6-11.</mixed-citation><mixed-citation xml:lang="en">Аруин Л.И. Апоптоз и патология печени // Рос. журн. гастроэнтерол., гепатол., колопроктол. - 1998. - Т. 8, № 2. - С. 6-11.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гальперин Э.И., Семендяева М.И., Неклюдова Е.А. Недостаточность печени. - Москва: Медицина, 1978. - 328 с.</mixed-citation><mixed-citation xml:lang="en">Гальперин Э.И., Семендяева М.И., Неклюдова Е.А. Недостаточность печени. - Москва: Медицина, 1978. - 328 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Еремеева Л.Ф., Ямпольский А.Ф. Экстракорпоральные методы лечения у пациентов с печеночно-клеточной недостаточностью // Актуал. пробл. трансп. мед. - 2010. - Т. 22, № 4. -С. 139-149.</mixed-citation><mixed-citation xml:lang="en">Еремеева Л.Ф., Ямпольский А.Ф. Экстракорпоральные методы лечения у пациентов с печеночно-клеточной недостаточностью // Актуал. пробл. трансп. мед. - 2010. - Т. 22, № 4. -С. 139-149.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Журавель С.В. Острая печеночная недостаточность // ^^ilium medicum.- 2004. -Т. 6, № 6. - С. 26-31.</mixed-citation><mixed-citation xml:lang="en">Журавель С.В. Острая печеночная недостаточность // ^^ilium medicum.- 2004. -Т. 6, № 6. - С. 26-31.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Надинская М.Ю., Буеверов А.О. Печеночная энцефалопатия и методы ее метаболической коррекции // Бол. орг. пищевар. - 2001. - № 3. - С. 25-27.</mixed-citation><mixed-citation xml:lang="en">Ивашкин В.Т., Надинская М.Ю., Буеверов А.О. Печеночная энцефалопатия и методы ее метаболической коррекции // Бол. орг. пищевар. - 2001. - № 3. - С. 25-27.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Исраилова В.К., Айткожин Г.К. Современные представления о печеночной недостаточности и методы их лечения // Вестн. КАЗМНУ. - 2012. -№ 1. - С. 36-44.</mixed-citation><mixed-citation xml:lang="en">Исраилова В.К., Айткожин Г.К. Современные представления о печеночной недостаточности и методы их лечения // Вестн. КАЗМНУ. - 2012. -№ 1. - С. 36-44.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Каплан Е.Я., Эпштейн И.М. // В кн.: Применение О2 под повышенным давлением в медицине. - М.2, 1971. - C. 216-218.</mixed-citation><mixed-citation xml:lang="en">Каплан Е.Я., Эпштейн И.М. // В кн.: Применение О2 под повышенным давлением в медицине. - М.2, 1971. - C. 216-218.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Краковский А.И., Подлужный В.И., Федюшина Н.А. и др. Применима ли гипербарическая оксигенация при механической желтухе и острой печеночной недостаточности? // Хирургия. -1980. - № 1. - C. 60-64.</mixed-citation><mixed-citation xml:lang="en">Краковский А.И., Подлужный В.И., Федюшина Н.А. и др. Применима ли гипербарическая оксигенация при механической желтухе и острой печеночной недостаточности? // Хирургия. -1980. - № 1. - C. 60-64.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Маевская М.В., Буеверов М.В. Цитокины в патогенезе алкогольного гепатита и возможности терапии // Рос. журн. гастроэнтерол. гепатол., колопроктол. - 2009. - Т. 19, № 2. - С. 14-19.</mixed-citation><mixed-citation xml:lang="en">Маевская М.В., Буеверов М.В. Цитокины в патогенезе алкогольного гепатита и возможности терапии // Рос. журн. гастроэнтерол. гепатол., колопроктол. - 2009. - Т. 19, № 2. - С. 14-19.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Максимова И.Е., Фокина Т.С., Самецкая Н.Б. и др. // В кн.: Применение О2 под повышенным давлением в медицине. - М., 1971. -С. 125-126.</mixed-citation><mixed-citation xml:lang="en">Максимова И.Е., Фокина Т.С., Самецкая Н.Б. и др. // В кн.: Применение О2 под повышенным давлением в медицине. - М., 1971. -С. 125-126.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Мансуров Х.Х. Важнейшие проблемы современной гепатологии // Клин. мед. - 1987. -Т. 65, № 11. - С. 59-64.</mixed-citation><mixed-citation xml:lang="en">Мансуров Х.Х. Важнейшие проблемы современной гепатологии // Клин. мед. - 1987. -Т. 65, № 11. - С. 59-64.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Онищенко Г.Г. Ситуация и меры борьбы с вирусными гепатитами в Российской Федерации // Мед. каф. - 2002. - № 2. - C. 18-22.</mixed-citation><mixed-citation xml:lang="en">Онищенко Г.Г. Ситуация и меры борьбы с вирусными гепатитами в Российской Федерации // Мед. каф. - 2002. - № 2. - C. 18-22.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Пасечник И.Н., Кутепов Д.Е. Печеночная недостаточность: современные методы лечения. -М.: Медицина, 2009. - 240 с.</mixed-citation><mixed-citation xml:lang="en">Пасечник И.Н., Кутепов Д.Е. Печеночная недостаточность: современные методы лечения. -М.: Медицина, 2009. - 240 с.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Плеханов А.Н., Чикотеев С.П., Товаршинов А.И. Изменение уровней цитокинов в крови при развитии печеночной недостаточности после операций на печени // Мед. иммунол. - 2006. -Т. 8, № 1. - С. 61-66.</mixed-citation><mixed-citation xml:lang="en">Плеханов А.Н., Чикотеев С.П., Товаршинов А.И. Изменение уровней цитокинов в крови при развитии печеночной недостаточности после операций на печени // Мед. иммунол. - 2006. -Т. 8, № 1. - С. 61-66.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Черний В.И., Тюменцева С. Г., Шраменко Е. К. Фульминантная печеночная недостаточность. - Донецк, 2010. - 127 с.</mixed-citation><mixed-citation xml:lang="en">Черний В.И., Тюменцева С. Г., Шраменко Е. К. Фульминантная печеночная недостаточность. - Донецк, 2010. - 127 с.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Шерлок Ш., Дули Дж. Заболевания печени и желчных путей. - М.: Медицина, 1999. - 859 с.</mixed-citation><mixed-citation xml:lang="en">Шерлок Ш., Дули Дж. Заболевания печени и желчных путей. - М.: Медицина, 1999. - 859 с.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Aithal G.P., Watkins P.B., Andrade R.J. Case definition and phenotype standardization in drug-induced liver injury // Clin. pharm. and therap. - 2011. - Vol. 89. - P. 806-815.</mixed-citation><mixed-citation xml:lang="en">Aithal G.P., Watkins P.B., Andrade R.J. Case definition and phenotype standardization in drug-induced liver injury // Clin. pharm. and therap. - 2011. - Vol. 89. - P. 806-815.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Angeli P., Morando F., Cavallin M. Hepatorenal syndrome // Contrib. Nephrol. - 2011. -N 174. - Р. 46-55.</mixed-citation><mixed-citation xml:lang="en">Angeli P., Morando F., Cavallin M. Hepatorenal syndrome // Contrib. Nephrol. - 2011. -N 174. - Р. 46-55.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Awad S.S., Sawada S., Soldes O.S. et al. Can the clearance of tumor necrosis factor alpha and interleukin 6 be enhanced using an albumin dialysate hemodiafiltration system? // ASAIO J. - 2009. -Vol. 45, N 1. - P. 47-49.</mixed-citation><mixed-citation xml:lang="en">Awad S.S., Sawada S., Soldes O.S. et al. Can the clearance of tumor necrosis factor alpha and interleukin 6 be enhanced using an albumin dialysate hemodiafiltration system? // ASAIO J. - 2009. -Vol. 45, N 1. - P. 47-49.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bajaj J.S., Pinkerton S.D., Sanyal A.J. Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis // Hepatol. - 2012. - Vol. 55. - Р.1164-1171.</mixed-citation><mixed-citation xml:lang="en">Bajaj J.S., Pinkerton S.D., Sanyal A.J. Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis // Hepatol. - 2012. - Vol. 55. - Р.1164-1171.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bantel H., Schulze-Osthoff K. Mechanisms of cell death in acute liver failure // Front. Physiol. - 2012. -Vol. 79. - P. 56-64.</mixed-citation><mixed-citation xml:lang="en">Bantel H., Schulze-Osthoff K. Mechanisms of cell death in acute liver failure // Front. Physiol. - 2012. -Vol. 79. - P. 56-64.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bеkhchandani J., Metcalfe M., Illouz S. Extracorporeal liver perfusion system for artificial liver support across a membrane // J. Surg. Res. - 2011. -Vol. 171. - P. 139-147.</mixed-citation><mixed-citation xml:lang="en">Bеkhchandani J., Metcalfe M., Illouz S. Extracorporeal liver perfusion system for artificial liver support across a membrane // J. Surg. Res. - 2011. -Vol. 171. - P. 139-147.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Belir B.M., Guinette D., Karrer F. et al. Hepatocyte transplantation in acute liver failure // Liver Transpl. - 2000. - N 6. - P. 32-40.</mixed-citation><mixed-citation xml:lang="en">Belir B.M., Guinette D., Karrer F. et al. Hepatocyte transplantation in acute liver failure // Liver Transpl. - 2000. - N 6. - P. 32-40.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Berghe T.V., Van Loo G., Saelens X. et al. Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD // J. Biol. Chem. - 2004. - N 4. - P. 49-53.</mixed-citation><mixed-citation xml:lang="en">Berghe T.V., Van Loo G., Saelens X. et al. Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD // J. Biol. Chem. - 2004. - N 4. - P. 49-53.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Bernal W., Auzinger G., Dhawan A. Acute liver failure // Lancet. - 2010. - Vol. 376. -P. 190-201.</mixed-citation><mixed-citation xml:lang="en">Bernal W., Auzinger G., Dhawan A. Acute liver failure // Lancet. - 2010. - Vol. 376. -P. 190-201.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bramhall S.R. Aetiology and outcome of acute liver failure // HPB (Oxford). - 2009. -Vol. 11, N 5. - Р. 429-434.</mixed-citation><mixed-citation xml:lang="en">Bramhall S.R. Aetiology and outcome of acute liver failure // HPB (Oxford). - 2009. -Vol. 11, N 5. - Р. 429-434.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Butterworth R.F. Reprint of: Neuroinflammation in acute liver failure: Mechanisms and novel therapeutic targets // Neurochem. Int. - 2012. -Vol. 60. - Р. 715-722.</mixed-citation><mixed-citation xml:lang="en">Butterworth R.F. Reprint of: Neuroinflammation in acute liver failure: Mechanisms and novel therapeutic targets // Neurochem. Int. - 2012. -Vol. 60. - Р. 715-722.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Canbay A., Tacke F., Hadem J. et al. Acute liver failure: a life-threatening disease // Dtsch. Arztebl. Int. - 2011. - Vol. 108, N 42. - Р. 714-720.</mixed-citation><mixed-citation xml:lang="en">Canbay A., Tacke F., Hadem J. et al. Acute liver failure: a life-threatening disease // Dtsch. Arztebl. Int. - 2011. - Vol. 108, N 42. - Р. 714-720.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Cao H., Yang J., Yu J. Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure // BMC Med. - 2012. - Vol. 6, N 10. - P. 56-65.</mixed-citation><mixed-citation xml:lang="en">Cao H., Yang J., Yu J. Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure // BMC Med. - 2012. - Vol. 6, N 10. - P. 56-65.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Chari R.S., Collins B., Magee J.C. et al. Brief report: Treatment of hepatic failure with ex vivo pigliver perfusion followed by liver transplantation // N. Engl. J. Med. - 1994. - Vol. 331. - P. 234-237.</mixed-citation><mixed-citation xml:lang="en">Chari R.S., Collins B., Magee J.C. et al. Brief report: Treatment of hepatic failure with ex vivo pigliver perfusion followed by liver transplantation // N. Engl. J. Med. - 1994. - Vol. 331. - P. 234-237.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Cox N.R., Mohant S.R. Acute Liver Failure // Hospital Physician. - 2009. - Vol. 34. - P. 7-15.</mixed-citation><mixed-citation xml:lang="en">Cox N.R., Mohant S.R. Acute Liver Failure // Hospital Physician. - 2009. - Vol. 34. - P. 7-15.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Foley D.P., Vittimberga F.J., Quarfordt S.H. et al. Biliary secretion of extracorporeal porcine livers with single and dual vessel perfusion // Transplantation. - 1999. - Vol. 68. - P. 362-368.</mixed-citation><mixed-citation xml:lang="en">Foley D.P., Vittimberga F.J., Quarfordt S.H. et al. Biliary secretion of extracorporeal porcine livers with single and dual vessel perfusion // Transplantation. - 1999. - Vol. 68. - P. 362-368.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Frei P., Minder E.I., Corti N. Liver Transplantation because of Acute Liver Failure due to Heme Arginate Overdose in a Patient with Acute Intermittent Porphyria // Case Rep. Gastroenterol. - 2012. -Vol. 6, N 1. - Р. 190-196.</mixed-citation><mixed-citation xml:lang="en">Frei P., Minder E.I., Corti N. Liver Transplantation because of Acute Liver Failure due to Heme Arginate Overdose in a Patient with Acute Intermittent Porphyria // Case Rep. Gastroenterol. - 2012. -Vol. 6, N 1. - Р. 190-196.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hay J.E. Liver disease in pregnancy // Hepatol. - 2008. - Vol. 47, N 3. - P. 1067-1076.</mixed-citation><mixed-citation xml:lang="en">Hay J.E. Liver disease in pregnancy // Hepatol. - 2008. - Vol. 47, N 3. - P. 1067-1076.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Harbrecht B.G. Predicting outcome in patients with acute liver failure: what works best? // Crit. Care Med. -2012. - Vol. 40, N 5. - P. 1666-1667.</mixed-citation><mixed-citation xml:lang="en">Harbrecht B.G. Predicting outcome in patients with acute liver failure: what works best? // Crit. Care Med. -2012. - Vol. 40, N 5. - P. 1666-1667.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hattori H., Higuchi Y., Tsuji M. Living-related liver transplantation and neurological outcome in children with fulminant hepatic failure // Transplantation. - 1998. - Vol. 65. - P. 686-692.</mixed-citation><mixed-citation xml:lang="en">Hattori H., Higuchi Y., Tsuji M. Living-related liver transplantation and neurological outcome in children with fulminant hepatic failure // Transplantation. - 1998. - Vol. 65. - P. 686-692.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Hoofnagle J.H., Carithers R.L., Shapiro C. et al: Fulminant hepatic failure: Summary of a workshop // Hepatology. - 1995. - Vol. 21. - P. 240-252.</mixed-citation><mixed-citation xml:lang="en">Hoofnagle J.H., Carithers R.L., Shapiro C. et al: Fulminant hepatic failure: Summary of a workshop // Hepatology. - 1995. - Vol. 21. - P. 240-252.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Karkhanis J., Lee W.M., Brown R.S. Steroid use in drug induced and cryptogenic causes of acute liver failure // AASLD. - 2008. - Vol. 48, N 4. -Р. 446-447.</mixed-citation><mixed-citation xml:lang="en">Karkhanis J., Lee W.M., Brown R.S. Steroid use in drug induced and cryptogenic causes of acute liver failure // AASLD. - 2008. - Vol. 48, N 4. -Р. 446-447.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kobashi-Margain R.A., Gavilanes-Espinar J.G., Gutierrez-Grobe Y. Albumin dialysis with molecular adsorbent recirculating system (MARS) for the treatment of hepatic encephalopathy in liver failure // Ann. Hepatol. - 2011. - N 5. - Р. 70-76.</mixed-citation><mixed-citation xml:lang="en">Kobashi-Margain R.A., Gavilanes-Espinar J.G., Gutierrez-Grobe Y. Albumin dialysis with molecular adsorbent recirculating system (MARS) for the treatment of hepatic encephalopathy in liver failure // Ann. Hepatol. - 2011. - N 5. - Р. 70-76.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Kora S.A., Doddamani G.B., Doddamani U., Subacute Hepatic Failure // J. Clin. Diagn. Res. - 2011. - Vol. 5, N 1. - P. 134-137.</mixed-citation><mixed-citation xml:lang="en">Kora S.A., Doddamani G.B., Doddamani U., Subacute Hepatic Failure // J. Clin. Diagn. Res. - 2011. - Vol. 5, N 1. - P. 134-137.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar R., Bhatia V. Structured approach to treat patients with acute liver failure: A hepatic emergency // Indian J. Crit. Care Med. - 2012. - Vol. 16, N 1. - P. 1-7.</mixed-citation><mixed-citation xml:lang="en">Kumar R., Bhatia V. Structured approach to treat patients with acute liver failure: A hepatic emergency // Indian J. Crit. Care Med. - 2012. - Vol. 16, N 1. - P. 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Lacaille F. Liver transplantation and liver cell transplantation // Clin. Res. Hepatol. Gastroenterol. - 2012. - Vol. 36, N 3. - P. 304-307.</mixed-citation><mixed-citation xml:lang="en">Lacaille F. Liver transplantation and liver cell transplantation // Clin. Res. Hepatol. Gastroenterol. - 2012. - Vol. 36, N 3. - P. 304-307.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Laleman W., Verbeke L. Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions // Exp. Rev. Gastroenter. &amp; Hepatol. - 2011. - Vol. 5, N 4. - P. 523-537.</mixed-citation><mixed-citation xml:lang="en">Laleman W., Verbeke L. Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions // Exp. Rev. Gastroenter. &amp; Hepatol. - 2011. - Vol. 5, N 4. - P. 523-537.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Lee W.M. Liver: determining prognosis in acute liver failure // Nat. Rev. Gastroenterol. Hepatol. - 2012. - Vol. 9, N 4. - P.192-194.</mixed-citation><mixed-citation xml:lang="en">Lee W.M. Liver: determining prognosis in acute liver failure // Nat. Rev. Gastroenterol. Hepatol. - 2012. - Vol. 9, N 4. - P.192-194.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Liu H.M., Wang X.B., Zeng H. Survival analysis of short-term prognosis of patients with HBV-related acute-on-chronic liver failure // Zhonghua Yi Xue Za Zhi. - 2012. - Vol. 92, N 1. - P. 21-24.</mixed-citation><mixed-citation xml:lang="en">Liu H.M., Wang X.B., Zeng H. Survival analysis of short-term prognosis of patients with HBV-related acute-on-chronic liver failure // Zhonghua Yi Xue Za Zhi. - 2012. - Vol. 92, N 1. - P. 21-24.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Mochida S., Takikawa Y., Nakayama N. Diagnostic criteria of acute liver failure // Hepatol. Res. - 2011. -Vol. 41, N 9. - Р. 805-812.</mixed-citation><mixed-citation xml:lang="en">Mochida S., Takikawa Y., Nakayama N. Diagnostic criteria of acute liver failure // Hepatol. Res. - 2011. -Vol. 41, N 9. - Р. 805-812.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Mohanty A.K, Schiff E.R. The dilemma of idiopathic fulminant hepatic failure // Gastroenterol. Hepatol. - 2009. - N 5. - Р. 48-50.</mixed-citation><mixed-citation xml:lang="en">Mohanty A.K, Schiff E.R. The dilemma of idiopathic fulminant hepatic failure // Gastroenterol. Hepatol. - 2009. - N 5. - Р. 48-50.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Nibourg G.A., Chamuleau R.A., van Gulik T.M. Proliferative human cell sources applied as biocomponent in bioartificial livers: a review // Expert. Opin. Biol. Ther. - 2012. - Vol. 12, N 7. - P. 905-921.</mixed-citation><mixed-citation xml:lang="en">Nibourg G.A., Chamuleau R.A., van Gulik T.M. Proliferative human cell sources applied as biocomponent in bioartificial livers: a review // Expert. Opin. Biol. Ther. - 2012. - Vol. 12, N 7. - P. 905-921.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">O'Grady J.G. Acute liver failure // Postgrad. Med. J. - 2005. - Vol. 81. - P. 148-154.</mixed-citation><mixed-citation xml:lang="en">O'Grady J.G. Acute liver failure // Postgrad. Med. J. - 2005. - Vol. 81. - P. 148-154.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Pathikonda M., Munoz S. Acute Liver Failure // Ann. of Hepatol. - 2010. - Vol. 9, N 1. -P. 7-14.</mixed-citation><mixed-citation xml:lang="en">Pathikonda M., Munoz S. Acute Liver Failure // Ann. of Hepatol. - 2010. - Vol. 9, N 1. -P. 7-14.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Patel D., Mc Phail M.J., Cobbold J.F. Hepatic encephalopathy // Br. J. Hosp. Med. (Lond). -2012. -Vol. 73, N 2. - Р. 79-85.</mixed-citation><mixed-citation xml:lang="en">Patel D., Mc Phail M.J., Cobbold J.F. Hepatic encephalopathy // Br. J. Hosp. Med. (Lond). -2012. -Vol. 73, N 2. - Р. 79-85.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Patton H., Misel M., Gish R.G. Acute Liver Failure in Adults: An Evidence-Based Management Protocol for Clinicians // Gastroenterol. Hepatol. - 2012. - Vol. 8, N 3. - P. 161-212.</mixed-citation><mixed-citation xml:lang="en">Patton H., Misel M., Gish R.G. Acute Liver Failure in Adults: An Evidence-Based Management Protocol for Clinicians // Gastroenterol. Hepatol. - 2012. - Vol. 8, N 3. - P. 161-212.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Paugam-Burtz C., Wendon J. Case Scenario: Postoperative Liver Failure after Liver Resection in a Cirrhotic Patient // Anesthesiol. - 2012. -Vol. 116. - P. 705-711.</mixed-citation><mixed-citation xml:lang="en">Paugam-Burtz C., Wendon J. Case Scenario: Postoperative Liver Failure after Liver Resection in a Cirrhotic Patient // Anesthesiol. - 2012. -Vol. 116. - P. 705-711.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Rust C., Gores G.J. Hepatocyte transplantation in acute liver failure: A new therapeutic option for the next millennium? // Liver Transpl. - 2000. - N 6. -P. 41-43.</mixed-citation><mixed-citation xml:lang="en">Rust C., Gores G.J. Hepatocyte transplantation in acute liver failure: A new therapeutic option for the next millennium? // Liver Transpl. - 2000. - N 6. -P. 41-43.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Rusu E.E., Voiculescu M., Zilisteanu D.S. Molecular adsorbents recirculating system in patients with severe liver failure. Experience of a single Romanian centre // J. Gastrointestin. Liv. Dis. - 2009. - Vol. 18, N 3. - Р. 311-316.</mixed-citation><mixed-citation xml:lang="en">Rusu E.E., Voiculescu M., Zilisteanu D.S. Molecular adsorbents recirculating system in patients with severe liver failure. Experience of a single Romanian centre // J. Gastrointestin. Liv. Dis. - 2009. - Vol. 18, N 3. - Р. 311-316.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Sass D.A., Shakil A.O. Fulminant hepatic failure // Liver Transpl. - 2005. - Vol. 11, N 6. -Р. 594-605.</mixed-citation><mixed-citation xml:lang="en">Sass D.A., Shakil A.O. Fulminant hepatic failure // Liver Transpl. - 2005. - Vol. 11, N 6. -Р. 594-605.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Sedhain A., Adhikari S., Regmi S. Fulminant hepatic failure due to dengue // Kathmandu Univ. Med. J. - 2011 - Vol. 9, N 34. - P. 71-73.</mixed-citation><mixed-citation xml:lang="en">Sedhain A., Adhikari S., Regmi S. Fulminant hepatic failure due to dengue // Kathmandu Univ. Med. J. - 2011 - Vol. 9, N 34. - P. 71-73.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Slack A., Wendon J. Acute liver failure // Clin. Med. - 2011. - Vol. 11, N 3. - Р. 254-258.</mixed-citation><mixed-citation xml:lang="en">Slack A., Wendon J. Acute liver failure // Clin. Med. - 2011. - Vol. 11, N 3. - Р. 254-258.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Strom S.C., Fisher R.A., Thompson M.T. et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure // Transplantation. - 1997. - Vol. 63. - P. 559-569.</mixed-citation><mixed-citation xml:lang="en">Strom S.C., Fisher R.A., Thompson M.T. et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure // Transplantation. - 1997. - Vol. 63. - P. 559-569.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Stutchfield B.M., Simpson K., Wigmore S.J. Systematic review and meta-analysis of survival following extracorporeal liver support // Br. J. Surg. - 2011. - Vol. 98. - P. 623-631.</mixed-citation><mixed-citation xml:lang="en">Stutchfield B.M., Simpson K., Wigmore S.J. Systematic review and meta-analysis of survival following extracorporeal liver support // Br. J. Surg. - 2011. - Vol. 98. - P. 623-631.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Sundaram V., Shaikh O.S. Acute liver failure: current practice and recent advances // Gastroenterol. - Clin. North Am. - 2011. - Vol. 40, N 3. -Р. 523-539.</mixed-citation><mixed-citation xml:lang="en">Sundaram V., Shaikh O.S. Acute liver failure: current practice and recent advances // Gastroenterol. - Clin. North Am. - 2011. - Vol. 40, N 3. -Р. 523-539.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Trey C., Davidson C.S. The management of fulminant hepatic failure / In: H. Popper, F. Schaffner (eds): Progress in Liver Failure. - New York, Grune and Stratton, 1970. - P. 282-298.</mixed-citation><mixed-citation xml:lang="en">Trey C., Davidson C.S. The management of fulminant hepatic failure / In: H. Popper, F. Schaffner (eds): Progress in Liver Failure. - New York, Grune and Stratton, 1970. - P. 282-298.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Tritto G., Davies N.A., Jalan R. Liver replacement therapy // Semin. Respir. Crit. Care Med. - 2012. - Vol. 33, N 1. - Р. 70-79.</mixed-citation><mixed-citation xml:lang="en">Tritto G., Davies N.A., Jalan R. Liver replacement therapy // Semin. Respir. Crit. Care Med. - 2012. - Vol. 33, N 1. - Р. 70-79.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Wlodzimirow K.A., Eslami S., Abu-Hanna A. Acute liver failure: what is it? // Hepatol. -2012. -Vol. 55, N 4. - Р. 1306-1307.</mixed-citation><mixed-citation xml:lang="en">Wlodzimirow K.A., Eslami S., Abu-Hanna A. Acute liver failure: what is it? // Hepatol. -2012. -Vol. 55, N 4. - Р. 1306-1307.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Yarze J.C., Tulloss R.E. Acute Liver Injury and Renal Failure Due to Poisonous Mushroom (Amanita bisporigera) Ingestion // Am. J. Gastroenterol. - 2012. - Vol. 107, N 5. - P. 790-791.</mixed-citation><mixed-citation xml:lang="en">Yarze J.C., Tulloss R.E. Acute Liver Injury and Renal Failure Due to Poisonous Mushroom (Amanita bisporigera) Ingestion // Am. J. Gastroenterol. - 2012. - Vol. 107, N 5. - P. 790-791.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
