In the Republic of Kazakhstan, there a re the natural plague foci. For the analysis, the passport data of plague epizooty activity in the PreAral-Qaraqym plague focus of Qyzylorda Province were collected. The data were received in the spring and summer seasons of2013. For the research of plague epizooty, the places ofstucfy were determined. The selection of places was based on the parameters as a presence of settlements, annual data of plague epizooty activity in the focus. Then the places were studied by serological and bacteriological methods; and the plague epizooty was found in some of them. During spring and summer seasons the plague strains were isolatedfrom the plague hostRhombomys opimus and plague vectors X. skrjabini, H. asiaticum, N. laeviceps, Cit. tesguorum, E. oshanini. For spatial and temporal analysis, the received positive data were processed by ArcGIS 10 program. The tasks of the analysis were definition of the plague epizooty center for plague risk zoning of the area; definition of direction of the plague epizooty for calculation of possibility of the plague epizooty increasing; calculation of plague epizooty radius for conducting of plague prophylaxis measures; definition of zones where the possibility to be infected with plague is high for population. The plague epizooty model of PreAral-Qaraqym plague focus was created, in the framework of plague epidemiological surveillance system, application the modeling in program ArcGIS 10 is useful instrument for detection of plague risk areas, and conduction of plague prophylaxis measures for protection of local population form the plague.