actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-1173Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS OF LITERATUREОБЗОР БАКТЕРИИ ПОРЯДКА RICKETTSIALES, АССОЦИИРОВАННЫХ С ИКСОДОВЫМИ КЛЕЩАМИ В ЯПОНИИOVERVIEW OF TICK-ASSOCIATED RICKETTSIALES BACTERIA IN JAPANОхашиН. ..OhashiN. ..ohashi@u-shizuoka-ken.ac.jpЙошикаваЙ. ..YoshikawaY. ..noemail@neicon.ruМасузаваТ. ..MasuzawaT. ..noemail@neicon.ruUniversity of ShizuokaRussian FederationChiba Institute of Science (CIS)Russian Federation20122809201205(1)379381Copyright © Охаши Н..., Йошикава Й..., Масузава Т..., 20122012Охаши Н..., Йошикава Й..., Масузава Т...Ohashi N..., Yoshikawa Y..., Masuzawa T...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/1173

Бактерии порядка Rickettsiales являются облигатными внутриклеточными паразитами позвоночных и беспозвоночных животных и. некоторые из них вызывают тяжелые лихорадочные заболевания у человека и домашних животных. В Японии хорошо известны микроорганизмы. Rickettsia japonica и Orientia tsutsugamushi, которые являются возбудителями Японской пятнистой лихорадки, переносимой, иксодовыми клещами и лихорадки Цуцугамуши, переносимой соответственно краснотелковыми клещами. В последние годы появляется много сообщений о выявлении, преимущественно молекулярногенетическими методами, в Японии нескольких новых бактерий порядка Rickettsiales, ассоциированных с клещами. Некоторые из этих бактерий могут иметь существенное ветеринарное или медицинское значение. Подобные бактерии включают риккетсий группы клещевых пятнистых лихорадок не относящихся к R. japonica, Ehrlichia spp., Anaplasma spp., и Neoehrlichia sp. В данном сообщении характеризуются основные представители этих групп, обитающие на территории. Японии.

Rickettsiales bacteria are obligatory intracellular parasites in vertebrates and/or invertebrates, and some cause severe febrile illness in humans as well as livestock. In Japan, "Rickettsia japonica" and "Orientia tsutsugamushi" are well known as causative agents for "Japanese spotted fever" transmitted by ticks and. "Tsutsugamushi disease" transmitted by mites, respectively. In recent years, many researchers have reported the presence of several tick-associated. Rickettsiales bacteria in Japan, mostly by molecular-based analyses. Some of these might be public health or veterinary significance. Such. Rickettsiales bacteria include spotted fever group rickettsiae other than R. japonica, Ehrlichia spp., Anaplasma spp., and. Neoehrlichia sp. We will summarize and. introduce the representatives of these Rickettsiales bacteria present in Japan.

RickettsialesRickettsiaEhrlichiaAnaplasmaNeoehrlichiaReferencesDumler J.S., Barbet A.F., Bekker C.P., Dasch G.A. et al. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and ‘HGE agent' as subjective synonyms of Ehrlichia phagocytophila // Int. J. Syst. Evol. Microbiol. - 2001, Nov. - Vol. 51 (Pt 6). - P. 2145-2465.Dumler J.S., Barbet A.F., Bekker C.P., Dasch G.A. et al. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and ‘HGE agent' as subjective synonyms of Ehrlichia phagocytophila // Int. J. Syst. Evol. Microbiol. - 2001, Nov. - Vol. 51 (Pt 6). - P. 2145-2465.Kawahara M., Rikihisa Y., Isogai E., Takahashi M. et al. Ultrastructure and phylogenetic analysis of ‘Candidatus Neoehrlichia mikurensis' in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks // Int. J. Syst. Evol. Microbiol. -2004, Sep. - Vol. 54 (Pt 5). - P. 1837-1843.Kawahara M., Rikihisa Y., Isogai E., Takahashi M. et al. Ultrastructure and phylogenetic analysis of ‘Candidatus Neoehrlichia mikurensis' in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks // Int. J. Syst. Evol. Microbiol. -2004, Sep. - Vol. 54 (Pt 5). - P. 1837-1843.Mahara F., Koga K., Sawada S., Taniguchi T. et al. The first report of the rickettsial infections of spotted fever group in Japan: three clinical cases // Kansenshogaku Zasshi. - 1985. - Vol. 59. -P. 1165-1171.Mahara F., Koga K., Sawada S., Taniguchi T. et al. The first report of the rickettsial infections of spotted fever group in Japan: three clinical cases // Kansenshogaku Zasshi. - 1985. - Vol. 59. -P. 1165-1171.Uchida T., Uchiyama T., Kumano K., Walker D.H. Rickettsia japonica sp. nov., the etiological agent of spotted fever group rickettsiosis in Japan // Int. J. Syst. Bacteriol. - 1992, Apr. - Vol. 42 (2). - P. 303-305.Uchida T., Uchiyama T., Kumano K., Walker D.H. Rickettsia japonica sp. nov., the etiological agent of spotted fever group rickettsiosis in Japan // Int. J. Syst. Bacteriol. - 1992, Apr. - Vol. 42 (2). - P. 303-305.Fournier P.E., Fujita H., Takada N., Raoult D. Genetic identification of rickettsiae isolated from ticks in Japan // J. Clin. Microbiol. - 2002, Jun. -Vol. 40 (6). - P. 2176-2181.Fournier P.E., Fujita H., Takada N., Raoult D. Genetic identification of rickettsiae isolated from ticks in Japan // J. Clin. Microbiol. - 2002, Jun. -Vol. 40 (6). - P. 2176-2181.Fournier P.E., Takada N., Fujita H., Raoult D. Rickettsia tamurae sp. nov., isolated from Amblyomma testudinarium ticks // Int. J. Syst. Evol. Microbiol. -2006, Jul. - Vol. 56 (Pt. 7). - P. 1673-1675.Fournier P.E., Takada N., Fujita H., Raoult D. Rickettsia tamurae sp. nov., isolated from Amblyomma testudinarium ticks // Int. J. Syst. Evol. Microbiol. -2006, Jul. - Vol. 56 (Pt. 7). - P. 1673-1675.Fujita H., Fournier P.E., Takada N., Saito T. et al. Rickettsia asiatica sp. nov., isolated in Japan // Int. J. Syst. Evol. Microbiol. - 2006, Oct. -Vol. 56 (Pt. 10). - P. 2365-2368.Fujita H., Fournier P.E., Takada N., Saito T. et al. Rickettsia asiatica sp. nov., isolated in Japan // Int. J. Syst. Evol. Microbiol. - 2006, Oct. -Vol. 56 (Pt. 10). - P. 2365-2368.Inokuma H., Ohashi M., Jilintai, Tanabe S. et al. Prevalence of tick-borne Rickettsia and Ehrlichia in Ixodes persulcatus and Ixodes ovatus in Tokachi district, Eastern Hokkaido, Japan // J. Vet. Med. Sci. - 2007, Jun. - Vol. 69 (6). - P. 661 -664.Inokuma H., Ohashi M., Jilintai, Tanabe S. et al. Prevalence of tick-borne Rickettsia and Ehrlichia in Ixodes persulcatus and Ixodes ovatus in Tokachi district, Eastern Hokkaido, Japan // J. Vet. Med. Sci. - 2007, Jun. - Vol. 69 (6). - P. 661 -664.Ando S., Kurosawa M., Sakata A., Fujita H. et al. Human Rickettsia heilongjiangensis infection, Japan // Emerg. Infect. Dis. - 2010, Aug. - Vol. 16 (8). -P. 1306-1308.Ando S., Kurosawa M., Sakata A., Fujita H. et al. Human Rickettsia heilongjiangensis infection, Japan // Emerg. Infect. Dis. - 2010, Aug. - Vol. 16 (8). -P. 1306-1308.Fujita H. Cell culture system for isolation of disease agents: 15 years of experience in Ohara Research Laboratory // Annual Report of Ohara General Hospital. Fukushima (Japan); Ohara General Hospital. - 2008. - P. 21-42.Fujita H. Cell culture system for isolation of disease agents: 15 years of experience in Ohara Research Laboratory // Annual Report of Ohara General Hospital. Fukushima (Japan); Ohara General Hospital. - 2008. - P. 21-42.Inokuma H., Seino N., Suzuki M., Kaji K. et al. Detection of Rickettsia helvetica DNA from peripheral blood of Sika deer (Cervus nippon yesoensis) in Japan // J. Wildl. Dis. - 2008, Jan. - Vol. 44 (1). -P. 164-167.Inokuma H., Seino N., Suzuki M., Kaji K. et al. Detection of Rickettsia helvetica DNA from peripheral blood of Sika deer (Cervus nippon yesoensis) in Japan // J. Wildl. Dis. - 2008, Jan. - Vol. 44 (1). -P. 164-167.National Institute of Infectious Diseases and Tuberculosis and Infectious Diseases Control Division, Ministry of Health, Labour and Welfare. Scrub typhs and Japanese spotted fever in Japan, as of December 2006 // Infectious Agents Surveillance Reprot. -2006. - P. 27-32.National Institute of Infectious Diseases and Tuberculosis and Infectious Diseases Control Division, Ministry of Health, Labour and Welfare. Scrub typhs and Japanese spotted fever in Japan, as of December 2006 // Infectious Agents Surveillance Reprot. -2006. - P. 27-32.Imaoka K., Kaneko S., Tabara K., Kusatake K. et al. The First Human Case of Rickettsia tamurae infection in Japan // Case Rep. Dermatol. - 2011. -Vol. 3 (1). - P. 68-73.Imaoka K., Kaneko S., Tabara K., Kusatake K. et al. The First Human Case of Rickettsia tamurae infection in Japan // Case Rep. Dermatol. - 2011. -Vol. 3 (1). - P. 68-73.Wen B., Rikihisa Y., Mott J., Fuerst P.A. et al. Ehrlichia muris sp. nov., identified on the basis of 16S rRNA base sequences and serological, morphological, and biological characteristics // Int. J. Syst. Bacteriol. -1995, Apr. - Vol. 45 (2). - P. 250-254.Wen B., Rikihisa Y., Mott J., Fuerst P.A. et al. Ehrlichia muris sp. nov., identified on the basis of 16S rRNA base sequences and serological, morphological, and biological characteristics // Int. J. Syst. Bacteriol. -1995, Apr. - Vol. 45 (2). - P. 250-254.Shibata S., Kawahara M., Rikihisa Y., Fujita H. et al. New Ehrlichia species closely related to Ehrlichia chaffeensis isolated from Ixodes ovatus ticks in Japan // J. Clin. Microbiol. - 2000, Apr. - Vol. 38 (4). -P. 1331 -1338.Shibata S., Kawahara M., Rikihisa Y., Fujita H. et al. New Ehrlichia species closely related to Ehrlichia chaffeensis isolated from Ixodes ovatus ticks in Japan // J. Clin. Microbiol. - 2000, Apr. - Vol. 38 (4). -P. 1331 -1338.Naitou H., Kawaguchi D., Nishimura Y., Inayoshi M. et al. Molecular identification of Ehrlichia species and ‘Candidatus Neoehrlichia mikurensis' from ticks and wild rodents in Shizuoka and Nagano Prefectures, Japan // Microbiol. Immunol. - 2006. -Vol. 50 (1). - P. 45-51.Naitou H., Kawaguchi D., Nishimura Y., Inayoshi M. et al. Molecular identification of Ehrlichia species and ‘Candidatus Neoehrlichia mikurensis' from ticks and wild rodents in Shizuoka and Nagano Prefectures, Japan // Microbiol. Immunol. - 2006. -Vol. 50 (1). - P. 45-51.Inokuma H., Ohno K., Onishi T., Raoult D. et al. Detection of ehrlichial infection by PCR in dogs from Yamaguchi and Okinawa Prefectures, Japan // J. Vet. Med. Sci. - 2001, Jul. - Vol. 63 (7). - P. 815-817.Inokuma H., Ohno K., Onishi T., Raoult D. et al. Detection of ehrlichial infection by PCR in dogs from Yamaguchi and Okinawa Prefectures, Japan // J. Vet. Med. Sci. - 2001, Jul. - Vol. 63 (7). - P. 815-817.Matsumoto K., Takeuchi T., Yokoyama N., Katagiri Y. et al. Detection of the new Ehrlichia species closely related to Ehrlichia ewingii from Haemaphysalis longicornis in Yonaguni Island, Okinawa, Japan // J. Vet. Med. Sci. - 2011, Nov. - Vol. 73 (11). -P. 1485-1488.Matsumoto K., Takeuchi T., Yokoyama N., Katagiri Y. et al. Detection of the new Ehrlichia species closely related to Ehrlichia ewingii from Haemaphysalis longicornis in Yonaguni Island, Okinawa, Japan // J. Vet. Med. Sci. - 2011, Nov. - Vol. 73 (11). -P. 1485-1488.Kawahara M., Tajima T., Torii H., Yabutani M. et al. Ehrlichia chaffeensis infection of sika deer, Japan // Emerg. Infect. Dis. - 2009, Dec. - Vol. 15 (12). -P. 1991 -1993.Kawahara M., Tajima T., Torii H., Yabutani M. et al. Ehrlichia chaffeensis infection of sika deer, Japan // Emerg. Infect. Dis. - 2009, Dec. - Vol. 15 (12). -P. 1991 -1993.Ohashi N., Inayoshi M., Kitamura K., Kawamori F. et al. Anaplasma phagocytophilum-infected ticks // Emerg. Infect. Dis. - 2005, Nov. -Vol. 11 (11). - P. 1780-1783.Ohashi N., Inayoshi M., Kitamura K., Kawamori F. et al. Anaplasma phagocytophilum-infected ticks // Emerg. Infect. Dis. - 2005, Nov. -Vol. 11 (11). - P. 1780-1783.Gaowa, Wuritu, Wu D., Yoshikawa Y. et al. Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild deer in Japan // Jpn J. Infect. Dis. - 2012. - Vol. 65 (1). - P. 79-83.Gaowa, Wuritu, Wu D., Yoshikawa Y. et al. Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild deer in Japan // Jpn J. Infect. Dis. - 2012. - Vol. 65 (1). - P. 79-83.Kawahara M., Rikihisa Y., Lin Q., Isogai E. et al. Novel genetic variants of Anaplasma phagocytophilum, Anaplasma bovis, Anaplasma centrale, and a novel Ehrlichia sp. in wild deer and ticks on two major islands in Japan // Appl. Environ. Microbiol. - 2006, Feb. -Vol. 72 (2). - P. 1102-1109.Kawahara M., Rikihisa Y., Lin Q., Isogai E. et al. Novel genetic variants of Anaplasma phagocytophilum, Anaplasma bovis, Anaplasma centrale, and a novel Ehrlichia sp. in wild deer and ticks on two major islands in Japan // Appl. Environ. Microbiol. - 2006, Feb. -Vol. 72 (2). - P. 1102-1109.Masuzawa T., Uchishima Y., Fukui T., Okamoto Y. et al. Detection of Anaplasma phagocytophilum from Wild Boars and Deer in Japan // Jpn J. Infect. Dis. - 2011. - Vol. 64 (4). -P. 333-336.Masuzawa T., Uchishima Y., Fukui T., Okamoto Y. et al. Detection of Anaplasma phagocytophilum from Wild Boars and Deer in Japan // Jpn J. Infect. Dis. - 2011. - Vol. 64 (4). -P. 333-336.Inokuma H., Fujii K., Matsumoto K., Okuda M. et al. Demonstration of Anaplasma (Ehrlichia) platys inclusions in peripheral blood platelets of a dog in Japan // Vet. Parasitol. - 2002, Dec. - Vol. 110 (1-2). -P. 145-152.Inokuma H., Fujii K., Matsumoto K., Okuda M. et al. Demonstration of Anaplasma (Ehrlichia) platys inclusions in peripheral blood platelets of a dog in Japan // Vet. Parasitol. - 2002, Dec. - Vol. 110 (1-2). -P. 145-152.Naitou H., Kawaguchi D., Nishimura Y., Inayoshi M. et al. Molecular identification of Ehrlichia species and ‘Candidatus Neoehrlichia mikurensis' from ticks and wild rodents in Shizuoka and Nagano Prefectures, Japan // Microbiol. Immunol. - 2006. -Vol. 50 (1). - P. 45-51.Naitou H., Kawaguchi D., Nishimura Y., Inayoshi M. et al. Molecular identification of Ehrlichia species and ‘Candidatus Neoehrlichia mikurensis' from ticks and wild rodents in Shizuoka and Nagano Prefectures, Japan // Microbiol. Immunol. - 2006. -Vol. 50 (1). - P. 45-51.Tabara K., Arai S., Kawabuchi T., Itagaki A. et al. Molecular survey of Babesia microti, Ehrlichia species and Candidatus Neoehrlichia mikurensis in wild rodents from Shimane Prefecture, Japan // Microbiol. Immunol. - 2007. - Vol. 51 (4). -P. 359-367.Tabara K., Arai S., Kawabuchi T., Itagaki A. et al. Molecular survey of Babesia microti, Ehrlichia species and Candidatus Neoehrlichia mikurensis in wild rodents from Shimane Prefecture, Japan // Microbiol. Immunol. - 2007. - Vol. 51 (4). -P. 359-367.Welinder-Olsson C., Kjellin E., Vaht K., Jacobsson S. et al. First case of human "Candidatus Neoehrlichia mikurensis” infection in a febrile patient with chronic lymphocytic leukemia // J. Clin. Microbiol. - 2010, May. - Vol. 48 (5). -P. 1956- 1959.Welinder-Olsson C., Kjellin E., Vaht K., Jacobsson S. et al. First case of human "Candidatus Neoehrlichia mikurensis” infection in a febrile patient with chronic lymphocytic leukemia // J. Clin. Microbiol. - 2010, May. - Vol. 48 (5). -P. 1956- 1959.von Loewenich F.D., Geissdorfer W., Disque C., Matten J. et al. Detection of " Candidatus Neoehrlichia mikurensis” in two patients with severe febrile illnesses: evidence for a European sequence variant // J. Clin. Microbiol. - 2010, Jul. - Vol. 48 (7). -P. 2630-2635.von Loewenich F.D., Geissdorfer W., Disque C., Matten J. et al. Detection of " Candidatus Neoehrlichia mikurensis” in two patients with severe febrile illnesses: evidence for a European sequence variant // J. Clin. Microbiol. - 2010, Jul. - Vol. 48 (7). -P. 2630-2635.Fehr J.S., Bloemberg G.V., Ritter C., Hom-bach M. et al. Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis // Emerg. Infect. Dis. - 2010, Jul. - Vol. 16 (7). -P. 1127-1129.Fehr J.S., Bloemberg G.V., Ritter C., Hom-bach M. et al. Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis // Emerg. Infect. Dis. - 2010, Jul. - Vol. 16 (7). -P. 1127-1129.Rar V.A., Epikhina T.I., Livanova N.N., Panov V.V. et al. Study of the heterogeneity of 16s rRNA gene and groESL operone in the dna samples of Anaplasma phagocytophilum, Ehrlichia muris, and "Candidatus Neoehrlichia mikurensis” determined in the Ixodes persulcatus ticks in the area of Urals, Siberia, and far east of Russia // Mol. Gen. Mikrobiol. Virusol. - 2011. - Vol. 2. - P. 17-23.Rar V.A., Epikhina T.I., Livanova N.N., Panov V.V. et al. Study of the heterogeneity of 16s rRNA gene and groESL operone in the dna samples of Anaplasma phagocytophilum, Ehrlichia muris, and "Candidatus Neoehrlichia mikurensis” determined in the Ixodes persulcatus ticks in the area of Urals, Siberia, and far east of Russia // Mol. Gen. Mikrobiol. Virusol. - 2011. - Vol. 2. - P. 17-23.Carpi G., Cagnacci F., Wittekindt N.E., Zhao F. et al. Metagenomic profile of the bacterial communities associated with Ixodes ricinus ticks // PLoS One. - 2011. - Vol. 6 (10). - e25604.Carpi G., Cagnacci F., Wittekindt N.E., Zhao F. et al. Metagenomic profile of the bacterial communities associated with Ixodes ricinus ticks // PLoS One. - 2011. - Vol. 6 (10). - e25604.

The authors declare that there are no conflicts of interest present.