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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-1052</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В БИОЛОГИИ И МЕДИЦИНЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERIMENTAL RESEARCHES IN BIOLOGY AND MEDICINE</subject></subj-group></article-categories><title-group><article-title>ФОРМИРОВАНИЕ ОТВЕТНОЙ РЕАКЦИИ ОРГАНИЗМА КРЫС НА ОДНОКРАТНОЕ ВОЗДЕЙСТВИЕ ПРЕПАРАТОМ ТЕРИЗИДОН - 250 МГ + ПИРИДОКСИНА ГИДРОХЛОРИД - 10 МГ</article-title><trans-title-group xml:lang="en"><trans-title>FORMATION OF RESPONSE OF RATS ORGANISM ON SINGLE INFLUENCE OF TERIZIDONE - 250 MG + PYRIDOXINE HYDROCHLORIDE - 10 MG</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баденикова</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Badenikova</surname><given-names>K. A.</given-names></name></name-alternatives><email xlink:type="simple">osya_88@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юшков</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Yushkov</surname><given-names>G. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гущина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gushchina</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бенеманский</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Benemanskiy</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">emil09.42@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гущин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gushchin</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">pharmasyntez@gin.global-one.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВПО «Ангарская государственная техническая академия»</institution></aff><aff xml:lang="en"><institution>Angarsk State Technical Academy</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ОАО «Фармасинтез», Иркутск</institution></aff><aff xml:lang="en"><institution>Public Corporation «Farmasintez», Irkutsk</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>07</month><year>2012</year></pub-date><volume>0</volume><issue>4(2)</issue><fpage>163</fpage><lpage>166</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баденикова К.А., Юшков Г.Г., Гущина А.А., Бенеманский В.В., Гущин А.С., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Баденикова К.А., Юшков Г.Г., Гущина А.А., Бенеманский В.В., Гущин А.С.</copyright-holder><copyright-holder xml:lang="en">Badenikova K.A., Yushkov G.G., Gushchina A.A., Benemanskiy V.V., Gushchin A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/1052">https://www.actabiomedica.ru/jour/article/view/1052</self-uri><abstract><p>В статье представлены материалы экспериментального изучения препарата Теризидон с пиридоксина гидрохлоридом в условиях однократного перорального воздействия на животных в различных дозах в целях выявления ответной реакции организма для. использования в оценке общетоксического действия перспективного противотуберкулезного препарата. </p></abstract><trans-abstract xml:lang="en"><p>The article presents the materials of experimental study of Terizidone in combination with pyridoxine hydrochloride in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Теризидон с пиридоксина гидрохлоридом</kwd><kwd>экспериментальное исследование однократного воздействия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Terizidonе with pyridoxine hydrochloride</kwd><kwd>experimental research of single influence</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гуськова Т.А. 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